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Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain

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Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain. / Hradsky, Johannes; Bernstein, Hans-Gert; Marunde, Monika; Mikhaylova, Marina; Kreutz, Michael R.

In: J HISTOCHEM CYTOCHEM, Vol. 63, No. 10, 26.06.2015, p. 793-804.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hradsky, J, Bernstein, H-G, Marunde, M, Mikhaylova, M & Kreutz, MR 2015, 'Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain', J HISTOCHEM CYTOCHEM, vol. 63, no. 10, pp. 793-804.

APA

Hradsky, J., Bernstein, H-G., Marunde, M., Mikhaylova, M., & Kreutz, M. R. (2015). Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain. J HISTOCHEM CYTOCHEM, 63(10), 793-804.

Vancouver

Hradsky J, Bernstein H-G, Marunde M, Mikhaylova M, Kreutz MR. Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain. J HISTOCHEM CYTOCHEM. 2015 Jun 26;63(10):793-804.

Bibtex

@article{92687660bdc1446f8f2aae6a67747f04,
title = "Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain",
abstract = "Calneuron-1 and -2 are members of the neuronal calcium-binding protein family (nCaBP). They are transmembrane Calmodulin-like EF-hand Ca(2+)-sensors, and a function in the control of Golgi-to-plasma membrane vesicle trafficking has been assigned to both proteins. In this paper, we describe the distribution of Calneuron-1 in rat and human brains. We show that Calneuron-1 is ubiquitously expressed in all brain regions examined. The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. In addition, we identify two novel splice isoforms of Calneuron-1 with extended N-termini. These isoforms are particular abundant in the cerebellum. Taken together, these data set grounds for a better understanding of the cellular function of Calneurons.",
author = "Johannes Hradsky and Hans-Gert Bernstein and Monika Marunde and Marina Mikhaylova and Kreutz, {Michael R}",
year = "2015",
month = jun,
day = "26",
language = "English",
volume = "63",
pages = "793--804",
journal = "J HISTOCHEM CYTOCHEM",
issn = "0022-1554",
publisher = "Histochemical Society Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain

AU - Hradsky, Johannes

AU - Bernstein, Hans-Gert

AU - Marunde, Monika

AU - Mikhaylova, Marina

AU - Kreutz, Michael R

PY - 2015/6/26

Y1 - 2015/6/26

N2 - Calneuron-1 and -2 are members of the neuronal calcium-binding protein family (nCaBP). They are transmembrane Calmodulin-like EF-hand Ca(2+)-sensors, and a function in the control of Golgi-to-plasma membrane vesicle trafficking has been assigned to both proteins. In this paper, we describe the distribution of Calneuron-1 in rat and human brains. We show that Calneuron-1 is ubiquitously expressed in all brain regions examined. The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. In addition, we identify two novel splice isoforms of Calneuron-1 with extended N-termini. These isoforms are particular abundant in the cerebellum. Taken together, these data set grounds for a better understanding of the cellular function of Calneurons.

AB - Calneuron-1 and -2 are members of the neuronal calcium-binding protein family (nCaBP). They are transmembrane Calmodulin-like EF-hand Ca(2+)-sensors, and a function in the control of Golgi-to-plasma membrane vesicle trafficking has been assigned to both proteins. In this paper, we describe the distribution of Calneuron-1 in rat and human brains. We show that Calneuron-1 is ubiquitously expressed in all brain regions examined. The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. In addition, we identify two novel splice isoforms of Calneuron-1 with extended N-termini. These isoforms are particular abundant in the cerebellum. Taken together, these data set grounds for a better understanding of the cellular function of Calneurons.

M3 - SCORING: Journal article

VL - 63

SP - 793

EP - 804

JO - J HISTOCHEM CYTOCHEM

JF - J HISTOCHEM CYTOCHEM

SN - 0022-1554

IS - 10

ER -