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Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma

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Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma. / Süsens, U; Hermans-Borgmeyer, I; Borgmeyer, U.

In: BIOCHEM BIOPH RES CO, Vol. 267, No. 2, 19.01.2000, p. 532-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Süsens, U, Hermans-Borgmeyer, I & Borgmeyer, U 2000, 'Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma', BIOCHEM BIOPH RES CO, vol. 267, no. 2, pp. 532-5. https://doi.org/10.1006/bbrc.1999.1976

APA

Süsens, U., Hermans-Borgmeyer, I., & Borgmeyer, U. (2000). Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma. BIOCHEM BIOPH RES CO, 267(2), 532-5. https://doi.org/10.1006/bbrc.1999.1976

Vancouver

Süsens U, Hermans-Borgmeyer I, Borgmeyer U. Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma. BIOCHEM BIOPH RES CO. 2000 Jan 19;267(2):532-5. https://doi.org/10.1006/bbrc.1999.1976

Bibtex

@article{343b8eb97b964905bfbfa1366bfd1aab,
title = "Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma",
abstract = "Estrogen receptor-related receptors (ERRs) are orphan members of the nuclear receptor superfamily, closely related to the estrogen receptor. With a PCR-based cloning strategy we have identified two cDNA isoforms from a neonatal mouse whole brain cDNA library encoding ERRgamma. We show that alternative splicing gives rise to different 5'-ends. The predicted peptide sequence of ERRgamma2 differs from ERRgamma1 by additional 23 N-terminal residues. The presence of identical isoforms in human suggests a pivotal function of ERRgamma in mammalia. Northern blot analysis reveals that ERRgamma is expressed as early as day 11 of embryonic development (E11). Whole mount in situ hybridization analysis shows major expression of ERRgamma in the central nervous system at E12.5. In the adult mouse a 5.7 kb transcript is detected in heart, brain, kidney, and skeletal muscle. Therefore, ERRgamma may be involved in the differentiation, as well as the maintenance of the differentiated properties in the brain.",
keywords = "Alternative Splicing, Amino Acid Sequence, Animals, Base Sequence, Central Nervous System, Cloning, Molecular, DNA Primers, DNA, Complementary, Embryonic and Fetal Development, Female, Gene Expression Regulation, Developmental, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Pregnancy, Protein Isoforms, RNA, Messenger, Receptors, Cytoplasmic and Nuclear, Receptors, Estrogen, Tissue Distribution",
author = "U S{\"u}sens and I Hermans-Borgmeyer and U Borgmeyer",
note = "Copyright 2000 Academic Press.",
year = "2000",
month = jan,
day = "19",
doi = "10.1006/bbrc.1999.1976",
language = "English",
volume = "267",
pages = "532--5",
journal = "BIOCHEM BIOPH RES CO",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Alternative splicing and expression of the mouse estrogen receptor-related receptor gamma

AU - Süsens, U

AU - Hermans-Borgmeyer, I

AU - Borgmeyer, U

N1 - Copyright 2000 Academic Press.

PY - 2000/1/19

Y1 - 2000/1/19

N2 - Estrogen receptor-related receptors (ERRs) are orphan members of the nuclear receptor superfamily, closely related to the estrogen receptor. With a PCR-based cloning strategy we have identified two cDNA isoforms from a neonatal mouse whole brain cDNA library encoding ERRgamma. We show that alternative splicing gives rise to different 5'-ends. The predicted peptide sequence of ERRgamma2 differs from ERRgamma1 by additional 23 N-terminal residues. The presence of identical isoforms in human suggests a pivotal function of ERRgamma in mammalia. Northern blot analysis reveals that ERRgamma is expressed as early as day 11 of embryonic development (E11). Whole mount in situ hybridization analysis shows major expression of ERRgamma in the central nervous system at E12.5. In the adult mouse a 5.7 kb transcript is detected in heart, brain, kidney, and skeletal muscle. Therefore, ERRgamma may be involved in the differentiation, as well as the maintenance of the differentiated properties in the brain.

AB - Estrogen receptor-related receptors (ERRs) are orphan members of the nuclear receptor superfamily, closely related to the estrogen receptor. With a PCR-based cloning strategy we have identified two cDNA isoforms from a neonatal mouse whole brain cDNA library encoding ERRgamma. We show that alternative splicing gives rise to different 5'-ends. The predicted peptide sequence of ERRgamma2 differs from ERRgamma1 by additional 23 N-terminal residues. The presence of identical isoforms in human suggests a pivotal function of ERRgamma in mammalia. Northern blot analysis reveals that ERRgamma is expressed as early as day 11 of embryonic development (E11). Whole mount in situ hybridization analysis shows major expression of ERRgamma in the central nervous system at E12.5. In the adult mouse a 5.7 kb transcript is detected in heart, brain, kidney, and skeletal muscle. Therefore, ERRgamma may be involved in the differentiation, as well as the maintenance of the differentiated properties in the brain.

KW - Alternative Splicing

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Central Nervous System

KW - Cloning, Molecular

KW - DNA Primers

KW - DNA, Complementary

KW - Embryonic and Fetal Development

KW - Female

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - In Situ Hybridization

KW - Mice

KW - Molecular Sequence Data

KW - Pregnancy

KW - Protein Isoforms

KW - RNA, Messenger

KW - Receptors, Cytoplasmic and Nuclear

KW - Receptors, Estrogen

KW - Tissue Distribution

U2 - 10.1006/bbrc.1999.1976

DO - 10.1006/bbrc.1999.1976

M3 - SCORING: Journal article

C2 - 10631096

VL - 267

SP - 532

EP - 535

JO - BIOCHEM BIOPH RES CO

JF - BIOCHEM BIOPH RES CO

SN - 0006-291X

IS - 2

ER -