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Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children

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Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children. / Zhang, Zhengzheng; Duri, Kerina; Duisters, Kevin L W; Schoeman, Johannes C; Chandiwana, Panashe; Lindenburg, Peter; Jaeger, Julia; Ziegler, Susanne; Altfeld, Marcus; Kohler, Isabelle; Harms, Amy; Gumbo, Felicity Z; Hankemeier, Thomas; Bunders, Madeleine J.

In: AIDS, Vol. 37, No. 9, 15.07.2023, p. 1367-1376.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhang, Z, Duri, K, Duisters, KLW, Schoeman, JC, Chandiwana, P, Lindenburg, P, Jaeger, J, Ziegler, S, Altfeld, M, Kohler, I, Harms, A, Gumbo, FZ, Hankemeier, T & Bunders, MJ 2023, 'Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children', AIDS, vol. 37, no. 9, pp. 1367-1376. https://doi.org/10.1097/QAD.0000000000003574

APA

Zhang, Z., Duri, K., Duisters, K. L. W., Schoeman, J. C., Chandiwana, P., Lindenburg, P., Jaeger, J., Ziegler, S., Altfeld, M., Kohler, I., Harms, A., Gumbo, F. Z., Hankemeier, T., & Bunders, M. J. (2023). Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children. AIDS, 37(9), 1367-1376. https://doi.org/10.1097/QAD.0000000000003574

Vancouver

Zhang Z, Duri K, Duisters KLW, Schoeman JC, Chandiwana P, Lindenburg P et al. Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children. AIDS. 2023 Jul 15;37(9):1367-1376. https://doi.org/10.1097/QAD.0000000000003574

Bibtex

@article{dd11a1023194477cb58ecf823b22ebf6,
title = "Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children",
abstract = "OBJECTIVE: To determine immune-metabolic dysregulation in children born to women living with HIV.METHODS: Longitudinal immune-metabolomic analyses of plasma of 32 pregnant women with HIV (WHIV) and 12 uninfected women and their children up to 1.5 years of age were performed.RESULTS: Using liquid chromatography-mass spectrometry and a multiplex bead assay, 280 metabolites (57 amino acids, 116 positive lipids, 107 signalling lipids) and 24 immune mediators (e.g. cytokines) were quantified. combinational antiretroviral therapy (cART) exposure was categorized as cART initiation preconception (long), cART initiation postconception up to 4 weeks before birth (medium) and cART initiation within 3 weeks of birth (short). Plasma metabolite profiles differed between HIV-exposed-uninfected (HEU)-children with long cART exposure compared to HIV-unexposed-children (HUU). Specifically, higher levels of methionine-sulfone, which is associated with oxidative stress, were detected in HEU-children with long cART exposure compared to HUU-children. High infant methionine-sulfone levels were reflected by high prenatal plasma levels in the mother. Increased methionine-sulfone levels in the children were associated with decreased growth, including both weight and length.CONCLUSION: These findings based on longitudinal data demonstrate that dysregulation of metabolite networks associated with oxidative stress in children born to WHIV is associated with restricted infant growth.",
keywords = "Female, HIV Infections/drug therapy, Humans, Infant, Lipids, Methionine, Pregnancy, Pregnancy Complications, Infectious, Sulfones",
author = "Zhengzheng Zhang and Kerina Duri and Duisters, {Kevin L W} and Schoeman, {Johannes C} and Panashe Chandiwana and Peter Lindenburg and Julia Jaeger and Susanne Ziegler and Marcus Altfeld and Isabelle Kohler and Amy Harms and Gumbo, {Felicity Z} and Thomas Hankemeier and Bunders, {Madeleine J}",
note = "Copyright {\textcopyright} 2023 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2023",
month = jul,
day = "15",
doi = "10.1097/QAD.0000000000003574",
language = "English",
volume = "37",
pages = "1367--1376",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children

AU - Zhang, Zhengzheng

AU - Duri, Kerina

AU - Duisters, Kevin L W

AU - Schoeman, Johannes C

AU - Chandiwana, Panashe

AU - Lindenburg, Peter

AU - Jaeger, Julia

AU - Ziegler, Susanne

AU - Altfeld, Marcus

AU - Kohler, Isabelle

AU - Harms, Amy

AU - Gumbo, Felicity Z

AU - Hankemeier, Thomas

AU - Bunders, Madeleine J

N1 - Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2023/7/15

Y1 - 2023/7/15

N2 - OBJECTIVE: To determine immune-metabolic dysregulation in children born to women living with HIV.METHODS: Longitudinal immune-metabolomic analyses of plasma of 32 pregnant women with HIV (WHIV) and 12 uninfected women and their children up to 1.5 years of age were performed.RESULTS: Using liquid chromatography-mass spectrometry and a multiplex bead assay, 280 metabolites (57 amino acids, 116 positive lipids, 107 signalling lipids) and 24 immune mediators (e.g. cytokines) were quantified. combinational antiretroviral therapy (cART) exposure was categorized as cART initiation preconception (long), cART initiation postconception up to 4 weeks before birth (medium) and cART initiation within 3 weeks of birth (short). Plasma metabolite profiles differed between HIV-exposed-uninfected (HEU)-children with long cART exposure compared to HIV-unexposed-children (HUU). Specifically, higher levels of methionine-sulfone, which is associated with oxidative stress, were detected in HEU-children with long cART exposure compared to HUU-children. High infant methionine-sulfone levels were reflected by high prenatal plasma levels in the mother. Increased methionine-sulfone levels in the children were associated with decreased growth, including both weight and length.CONCLUSION: These findings based on longitudinal data demonstrate that dysregulation of metabolite networks associated with oxidative stress in children born to WHIV is associated with restricted infant growth.

AB - OBJECTIVE: To determine immune-metabolic dysregulation in children born to women living with HIV.METHODS: Longitudinal immune-metabolomic analyses of plasma of 32 pregnant women with HIV (WHIV) and 12 uninfected women and their children up to 1.5 years of age were performed.RESULTS: Using liquid chromatography-mass spectrometry and a multiplex bead assay, 280 metabolites (57 amino acids, 116 positive lipids, 107 signalling lipids) and 24 immune mediators (e.g. cytokines) were quantified. combinational antiretroviral therapy (cART) exposure was categorized as cART initiation preconception (long), cART initiation postconception up to 4 weeks before birth (medium) and cART initiation within 3 weeks of birth (short). Plasma metabolite profiles differed between HIV-exposed-uninfected (HEU)-children with long cART exposure compared to HIV-unexposed-children (HUU). Specifically, higher levels of methionine-sulfone, which is associated with oxidative stress, were detected in HEU-children with long cART exposure compared to HUU-children. High infant methionine-sulfone levels were reflected by high prenatal plasma levels in the mother. Increased methionine-sulfone levels in the children were associated with decreased growth, including both weight and length.CONCLUSION: These findings based on longitudinal data demonstrate that dysregulation of metabolite networks associated with oxidative stress in children born to WHIV is associated with restricted infant growth.

KW - Female

KW - HIV Infections/drug therapy

KW - Humans

KW - Infant

KW - Lipids

KW - Methionine

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Sulfones

U2 - 10.1097/QAD.0000000000003574

DO - 10.1097/QAD.0000000000003574

M3 - SCORING: Journal article

C2 - 37070556

VL - 37

SP - 1367

EP - 1376

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 9

ER -