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Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2

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Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2. / Rolf, Bettina; Lang, Doris; Hillenbrand, Rainer; Richter, Melanie; Schachner, Melitta; Bartsch, Udo.

In: J NEUROSCI RES, Vol. 71, No. 6, 15.03.2003, p. 835-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rolf, B, Lang, D, Hillenbrand, R, Richter, M, Schachner, M & Bartsch, U 2003, 'Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2', J NEUROSCI RES, vol. 71, no. 6, pp. 835-43. https://doi.org/10.1002/jnr.10533

APA

Rolf, B., Lang, D., Hillenbrand, R., Richter, M., Schachner, M., & Bartsch, U. (2003). Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2. J NEUROSCI RES, 71(6), 835-43. https://doi.org/10.1002/jnr.10533

Vancouver

Rolf B, Lang D, Hillenbrand R, Richter M, Schachner M, Bartsch U. Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2. J NEUROSCI RES. 2003 Mar 15;71(6):835-43. https://doi.org/10.1002/jnr.10533

Bibtex

@article{8e907ceff64d47c49103bf6b7b7fb647,
title = "Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2",
abstract = "The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate expression of CHL1 in response to an intraorbital crush of the adult mouse optic nerve. We also demonstrate that a single intravitreal application of fibroblast growth factor-2 (FGF-2) increases expression of CHL1 in retinal astrocytes and M{\"u}ller cells. Elevated expression of CHL1 by glial cells in injured optic nerves and astrocytes and M{\"u}ller cells in FGF-2-treated retinas suggests a role of the protein in the lesioned central nervous system. Results also suggest that trophic factors might exert part of their biological function by modifying expression of cell recognition molecules.",
keywords = "Animals, Astrocytes, Cell Adhesion Molecules, Fibroblast Growth Factor 2, Immunoblotting, Immunohistochemistry, In Situ Hybridization, Mice, Nerve Crush, Neural Cell Adhesion Molecule L1, Neuroglia, Neurons, Optic Nerve Injuries, Proteins, Up-Regulation, Journal Article, Research Support, Non-U.S. Gov't",
author = "Bettina Rolf and Doris Lang and Rainer Hillenbrand and Melanie Richter and Melitta Schachner and Udo Bartsch",
note = "Copyright 2002 Wiley-Liss, Inc.",
year = "2003",
month = mar,
day = "15",
doi = "10.1002/jnr.10533",
language = "English",
volume = "71",
pages = "835--43",
journal = "J NEUROSCI RES",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor-2

AU - Rolf, Bettina

AU - Lang, Doris

AU - Hillenbrand, Rainer

AU - Richter, Melanie

AU - Schachner, Melitta

AU - Bartsch, Udo

N1 - Copyright 2002 Wiley-Liss, Inc.

PY - 2003/3/15

Y1 - 2003/3/15

N2 - The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate expression of CHL1 in response to an intraorbital crush of the adult mouse optic nerve. We also demonstrate that a single intravitreal application of fibroblast growth factor-2 (FGF-2) increases expression of CHL1 in retinal astrocytes and Müller cells. Elevated expression of CHL1 by glial cells in injured optic nerves and astrocytes and Müller cells in FGF-2-treated retinas suggests a role of the protein in the lesioned central nervous system. Results also suggest that trophic factors might exert part of their biological function by modifying expression of cell recognition molecules.

AB - The close homologue of L1 (CHL1) is a member of the L1 family of cell recognition molecules. The protein is expressed by a variety of nerve cell types and subpopulations of glial cells in vivo and promotes elongation of neurites and survival of nerve cells in vitro. Here we demonstrate that glial cells up-regulate expression of CHL1 in response to an intraorbital crush of the adult mouse optic nerve. We also demonstrate that a single intravitreal application of fibroblast growth factor-2 (FGF-2) increases expression of CHL1 in retinal astrocytes and Müller cells. Elevated expression of CHL1 by glial cells in injured optic nerves and astrocytes and Müller cells in FGF-2-treated retinas suggests a role of the protein in the lesioned central nervous system. Results also suggest that trophic factors might exert part of their biological function by modifying expression of cell recognition molecules.

KW - Animals

KW - Astrocytes

KW - Cell Adhesion Molecules

KW - Fibroblast Growth Factor 2

KW - Immunoblotting

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Mice

KW - Nerve Crush

KW - Neural Cell Adhesion Molecule L1

KW - Neuroglia

KW - Neurons

KW - Optic Nerve Injuries

KW - Proteins

KW - Up-Regulation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/jnr.10533

DO - 10.1002/jnr.10533

M3 - SCORING: Journal article

C2 - 12605410

VL - 71

SP - 835

EP - 843

JO - J NEUROSCI RES

JF - J NEUROSCI RES

SN - 0360-4012

IS - 6

ER -