Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity

Annika Clamor; Maike M Hartmann; Ulf Köther; Christian Otte; Steffen Moritz; Tania M Lincoln

doi:10.1016/j.schres.2014.02.006

Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity

Standard

Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity. / Clamor, Annika; Hartmann, Maike M; Köther, Ulf; Otte, Christian; Moritz, Steffen; Lincoln, Tania M.

In: SCHIZOPHR RES, Vol. 154, No. 1-3, 2014, p. 73-78.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Clamor, A, Hartmann, MM, Köther, U, Otte, C, Moritz, S & Lincoln, TM 2014, 'Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity', SCHIZOPHR RES, vol. 154, no. 1-3, pp. 73-78. https://doi.org/10.1016/j.schres.2014.02.006

APA

Clamor, A., Hartmann, M. M., Köther, U., Otte, C., Moritz, S., & Lincoln, T. M. (2014). Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity. SCHIZOPHR RES, 154(1-3), 73-78. https://doi.org/10.1016/j.schres.2014.02.006

Vancouver

Clamor A, Hartmann MM, Köther U, Otte C, Moritz S, Lincoln TM. Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity. SCHIZOPHR RES. 2014;154(1-3):73-78. https://doi.org/10.1016/j.schres.2014.02.006

Bibtex

@article{94236e7c64af489d88966ddbeb78525d,

title = "Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity",

abstract = "Vulnerability-stress models implicate that alterations of the autonomous nervous system contribute to the development of psychosis. Previous research has found autonomic arousal alterations in psychotic disorders and at-risk individuals that are not explained by medication alone. To test whether these alterations are associated with the extent of an individual's vulnerability and whether they are specific to psychosis, we compared participants with psychosis (n=23), first-degree relatives of individuals with psychosis (n=21), and healthy participants with attenuated positive symptoms (n=23) to participants with depression (n=24) and healthy controls (n=24). At rest, skin conductance level was assessed and photoplethysmography was applied to measure time- and frequency-domain heart rate variability (HRV). Univariate and multivariate analyses of covariance with perceived stress and psychophysiological values as dependent variables showed significant between-group differences for perceived stress (p=.010), heart rate (p=.022), time-domain HRV indices (all ps≤.027), and vagal activity (p=.017). Group differences in sympathetic activity were nonsignificant (p=.069). In an additional analysis with medication as a second between-group factor, the physiological between-group differences remained significant or trend significant (all ps≤.060). With the exception of sympathetic activity, participants with psychosis exhibited more extreme arousal than the control groups. First-degree relatives and participants with attenuated symptoms showed comparable autonomic activity to healthy controls. Thus, the hypothesized association of an alteration of arousal and vulnerability to psychosis was not confirmed. However, particularly low time-domain HRV was found for psychosis, with significant differences to healthy controls (all ps≤.007) and to depression (all ps≤.004), with the latter indicating a specificity to psychosis.",

keywords = "Adult, Arousal, Depressive Disorder, Depressive Disorder, Major, Family, Female, Galvanic Skin Response, Heart Rate, Humans, Male, Photoplethysmography, Psychotic Disorders, Sensitivity and Specificity, Stress, Psychological",

author = "Annika Clamor and Hartmann, {Maike M} and Ulf K{\"o}ther and Christian Otte and Steffen Moritz and Lincoln, {Tania M}",

year = "2014",

doi = "10.1016/j.schres.2014.02.006",

language = "English",

volume = "154",

pages = "73--78",

journal = "SCHIZOPHR RES",

issn = "0920-9964",

publisher = "Elsevier",

number = "1-3",

}

RIS

TY - JOUR

T1 - Altered autonomic arousal in psychosis: an analysis of vulnerability and specificity

AU - Clamor, Annika

AU - Hartmann, Maike M

AU - Köther, Ulf

AU - Otte, Christian

AU - Moritz, Steffen

AU - Lincoln, Tania M

PY - 2014

Y1 - 2014

N2 - Vulnerability-stress models implicate that alterations of the autonomous nervous system contribute to the development of psychosis. Previous research has found autonomic arousal alterations in psychotic disorders and at-risk individuals that are not explained by medication alone. To test whether these alterations are associated with the extent of an individual's vulnerability and whether they are specific to psychosis, we compared participants with psychosis (n=23), first-degree relatives of individuals with psychosis (n=21), and healthy participants with attenuated positive symptoms (n=23) to participants with depression (n=24) and healthy controls (n=24). At rest, skin conductance level was assessed and photoplethysmography was applied to measure time- and frequency-domain heart rate variability (HRV). Univariate and multivariate analyses of covariance with perceived stress and psychophysiological values as dependent variables showed significant between-group differences for perceived stress (p=.010), heart rate (p=.022), time-domain HRV indices (all ps≤.027), and vagal activity (p=.017). Group differences in sympathetic activity were nonsignificant (p=.069). In an additional analysis with medication as a second between-group factor, the physiological between-group differences remained significant or trend significant (all ps≤.060). With the exception of sympathetic activity, participants with psychosis exhibited more extreme arousal than the control groups. First-degree relatives and participants with attenuated symptoms showed comparable autonomic activity to healthy controls. Thus, the hypothesized association of an alteration of arousal and vulnerability to psychosis was not confirmed. However, particularly low time-domain HRV was found for psychosis, with significant differences to healthy controls (all ps≤.007) and to depression (all ps≤.004), with the latter indicating a specificity to psychosis.

AB - Vulnerability-stress models implicate that alterations of the autonomous nervous system contribute to the development of psychosis. Previous research has found autonomic arousal alterations in psychotic disorders and at-risk individuals that are not explained by medication alone. To test whether these alterations are associated with the extent of an individual's vulnerability and whether they are specific to psychosis, we compared participants with psychosis (n=23), first-degree relatives of individuals with psychosis (n=21), and healthy participants with attenuated positive symptoms (n=23) to participants with depression (n=24) and healthy controls (n=24). At rest, skin conductance level was assessed and photoplethysmography was applied to measure time- and frequency-domain heart rate variability (HRV). Univariate and multivariate analyses of covariance with perceived stress and psychophysiological values as dependent variables showed significant between-group differences for perceived stress (p=.010), heart rate (p=.022), time-domain HRV indices (all ps≤.027), and vagal activity (p=.017). Group differences in sympathetic activity were nonsignificant (p=.069). In an additional analysis with medication as a second between-group factor, the physiological between-group differences remained significant or trend significant (all ps≤.060). With the exception of sympathetic activity, participants with psychosis exhibited more extreme arousal than the control groups. First-degree relatives and participants with attenuated symptoms showed comparable autonomic activity to healthy controls. Thus, the hypothesized association of an alteration of arousal and vulnerability to psychosis was not confirmed. However, particularly low time-domain HRV was found for psychosis, with significant differences to healthy controls (all ps≤.007) and to depression (all ps≤.004), with the latter indicating a specificity to psychosis.

KW - Adult

KW - Arousal

KW - Depressive Disorder

KW - Depressive Disorder, Major

KW - Family

KW - Female

KW - Galvanic Skin Response

KW - Heart Rate

KW - Humans

KW - Male

KW - Photoplethysmography

KW - Psychotic Disorders

KW - Sensitivity and Specificity

KW - Stress, Psychological

U2 - 10.1016/j.schres.2014.02.006

DO - 10.1016/j.schres.2014.02.006

M3 - SCORING: Journal article

C2 - 24582038

VL - 154

SP - 73

EP - 78

JO - SCHIZOPHR RES

JF - SCHIZOPHR RES

SN - 0920-9964

IS - 1-3

ER -