Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure
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Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure. / Agunbiade, K; Fonville, Leon; McGonigle, J; Elliott, R; Ersche, K D; Flechais, R; Orban, C; Murphy, A; Smith, D G; Suckling, J; Taylor, E M; Deakin, B; Robbins, T; Nutt, D J; Lingford-Hughes, A R; Paterson, L; ICCAM Consortium.
In: ADDICT BIOL, Vol. 27, No. 5, e13207, 01.09.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure
AU - Agunbiade, K
AU - Fonville, Leon
AU - McGonigle, J
AU - Elliott, R
AU - Ersche, K D
AU - Flechais, R
AU - Orban, C
AU - Murphy, A
AU - Smith, D G
AU - Suckling, J
AU - Taylor, E M
AU - Deakin, B
AU - Robbins, T
AU - Nutt, D J
AU - Lingford-Hughes, A R
AU - Paterson, L
AU - ICCAM Consortium
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Evidence suggests that alcohol dependence (AD) is associated with microstructural deficits in white matter, but the relationship with lifetime alcohol exposure and the impact of polydrug dependence is not well understood. Using diffusion tensor magnetic resonance (MR) imaging, we examined white matter microstructure in relation to alcohol and polydrug dependence using data from the Imperial College Cambridge Manchester (ICCAM) platform study. Tract-based spatial statistics were used to examine fractional anisotropy (FA) in a cohort of abstinent AD participants, most of whom had a lifetime history of dependence to nicotine. A further subgroup also had a lifetime history of dependence to cocaine and/or opiates. Individuals with AD had lower FA throughout the corpus callosum, and negative associations with alcohol and nicotine exposure were found. A group-by-age interaction effect was found showing greater reductions with age in the alcohol-dependent group within corpus callosum, overlapping with the group difference. We found no evidence of recovery with abstinence. A comparison of alcohol-only- and alcohol-polydrug-dependent groups found no differences in FA. Overall, our findings show that AD is associated with lower FA and suggest that these alterations are primarily driven by lifetime alcohol consumption and cigarette smoking, showing no relationship with exposure to other substances such as cocaine, opiates or cannabis. Reductions in FA across the adult lifespan are more pronounced in AD and offer further support for the notion of accelerated ageing in relation to alcohol dependence. These findings highlight there may be lasting structural differences in white matter in alcohol dependence, despite continued abstinence.
AB - Evidence suggests that alcohol dependence (AD) is associated with microstructural deficits in white matter, but the relationship with lifetime alcohol exposure and the impact of polydrug dependence is not well understood. Using diffusion tensor magnetic resonance (MR) imaging, we examined white matter microstructure in relation to alcohol and polydrug dependence using data from the Imperial College Cambridge Manchester (ICCAM) platform study. Tract-based spatial statistics were used to examine fractional anisotropy (FA) in a cohort of abstinent AD participants, most of whom had a lifetime history of dependence to nicotine. A further subgroup also had a lifetime history of dependence to cocaine and/or opiates. Individuals with AD had lower FA throughout the corpus callosum, and negative associations with alcohol and nicotine exposure were found. A group-by-age interaction effect was found showing greater reductions with age in the alcohol-dependent group within corpus callosum, overlapping with the group difference. We found no evidence of recovery with abstinence. A comparison of alcohol-only- and alcohol-polydrug-dependent groups found no differences in FA. Overall, our findings show that AD is associated with lower FA and suggest that these alterations are primarily driven by lifetime alcohol consumption and cigarette smoking, showing no relationship with exposure to other substances such as cocaine, opiates or cannabis. Reductions in FA across the adult lifespan are more pronounced in AD and offer further support for the notion of accelerated ageing in relation to alcohol dependence. These findings highlight there may be lasting structural differences in white matter in alcohol dependence, despite continued abstinence.
U2 - 10.1111/adb.13207
DO - 10.1111/adb.13207
M3 - SCORING: Journal article
VL - 27
JO - ADDICT BIOL
JF - ADDICT BIOL
SN - 1355-6215
IS - 5
M1 - e13207
ER -