Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload.
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Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload. / Schillinger, Wolfgang; Christians, Claus; Sossalla, Samuel; Teucher, Nils; Phuc, Nguyen Van; Kögler, Harald; Zeitz, Oliver; Hasenfuss, Gerd.
In: EUR J HEART FAIL, Vol. 9, No. 4, 4, 2007, p. 329-335.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Alpha1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload.
AU - Schillinger, Wolfgang
AU - Christians, Claus
AU - Sossalla, Samuel
AU - Teucher, Nils
AU - Phuc, Nguyen Van
AU - Kögler, Harald
AU - Zeitz, Oliver
AU - Hasenfuss, Gerd
PY - 2007
Y1 - 2007
N2 - Alpha1-adrenergic stimulation and mechanical load are considered crucial for the expression of sarcolemmal Na+/Ca2+ exchanger (NCX1). However, the interaction between these processes is unknown. We investigated electrically stimulated (1 Hz, 1.75 mmol/L Ca2+) rabbit ventricular trabeculae at physiological preload under stimulation by the selective alpha1-agonist phenylephrine (PE, 10 micromol/L). Using quantitative real-time PCR, downregulation of mRNA to 76.5% (p
AB - Alpha1-adrenergic stimulation and mechanical load are considered crucial for the expression of sarcolemmal Na+/Ca2+ exchanger (NCX1). However, the interaction between these processes is unknown. We investigated electrically stimulated (1 Hz, 1.75 mmol/L Ca2+) rabbit ventricular trabeculae at physiological preload under stimulation by the selective alpha1-agonist phenylephrine (PE, 10 micromol/L). Using quantitative real-time PCR, downregulation of mRNA to 76.5% (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 9
SP - 329
EP - 335
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 4
M1 - 4
ER -