Allogeneic transplantation versus chemotherapy as postremission therapy for acute myeloid leukemia: a prospective matched pairs analysis
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Allogeneic transplantation versus chemotherapy as postremission therapy for acute myeloid leukemia: a prospective matched pairs analysis. / Stelljes, Matthias; Krug, Utz; Beelen, Dietrich W; Braess, Jan; Sauerland, Maria C; Heinecke, Achim; Ligges, Sandra; Sauer, Tim; Tschanter, Petra; Thoennissen, Gabriela B; Berning, Björna; Kolb, Hans J; Reichle, Albrecht; Holler, Ernst; Schwerdtfeger, Rainer; Arnold, Renate; Scheid, Christoph; Müller-Tidow, Carsten; Woermann, Bernhard J; Hiddemann, Wolfgang; Berdel, Wolfgang E; Büchner, Thomas.
In: J CLIN ONCOL, Vol. 32, No. 4, 01.02.2014, p. 288-96.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Allogeneic transplantation versus chemotherapy as postremission therapy for acute myeloid leukemia: a prospective matched pairs analysis
AU - Stelljes, Matthias
AU - Krug, Utz
AU - Beelen, Dietrich W
AU - Braess, Jan
AU - Sauerland, Maria C
AU - Heinecke, Achim
AU - Ligges, Sandra
AU - Sauer, Tim
AU - Tschanter, Petra
AU - Thoennissen, Gabriela B
AU - Berning, Björna
AU - Kolb, Hans J
AU - Reichle, Albrecht
AU - Holler, Ernst
AU - Schwerdtfeger, Rainer
AU - Arnold, Renate
AU - Scheid, Christoph
AU - Müller-Tidow, Carsten
AU - Woermann, Bernhard J
AU - Hiddemann, Wolfgang
AU - Berdel, Wolfgang E
AU - Büchner, Thomas
PY - 2014/2/1
Y1 - 2014/2/1
N2 - PURPOSE: The majority of patients with acute myeloid leukemia (AML) who achieve complete remission (CR) relapse with conventional postremission chemotherapy. Allogeneic stem-cell transplantation (alloSCT) might improve survival at the expense of increased toxicity. It remains unknown for which patients alloSCT is preferable.PATIENTS AND METHODS: We compared the outcome of 185 matched pairs of a large multicenter clinical trial (AMLCG99). Patients younger than 60 years who underwent alloSCT in first remission (CR1) were matched to patients who received conventional postremission therapy. The main matching criteria were AML type, cytogenetic risk group, patient age, and time in first CR.RESULTS: In the overall pairwise compared AML population, the projected 7-year overall survival (OS) rate was 58% for the alloSCT and 46% for the conventional postremission treatment group (P = .037; log-rank test). Relapse-free survival (RFS) was 52% in the alloSCT group compared with 33% in the control group (P < .001). OS was significantly better for alloSCT in patient subgroups with nonfavorable chromosomal aberrations, patients older than 45 years, and patients with secondary AML or high-risk myelodysplastic syndrome. For the entire patient cohort, postremission therapy was an independent factor for OS (hazard ratio, 0.66; 95% CI, 0.49 to 0.89 for alloSCT v conventional chemotherapy), among age, cytogenetics, and bone marrow blasts after the first induction cycle.CONCLUSION: AlloSCT is the most potent postremission therapy for AML and is particularly active for patients 45 to 59 years of age and/or those with high-risk cytogenetics.
AB - PURPOSE: The majority of patients with acute myeloid leukemia (AML) who achieve complete remission (CR) relapse with conventional postremission chemotherapy. Allogeneic stem-cell transplantation (alloSCT) might improve survival at the expense of increased toxicity. It remains unknown for which patients alloSCT is preferable.PATIENTS AND METHODS: We compared the outcome of 185 matched pairs of a large multicenter clinical trial (AMLCG99). Patients younger than 60 years who underwent alloSCT in first remission (CR1) were matched to patients who received conventional postremission therapy. The main matching criteria were AML type, cytogenetic risk group, patient age, and time in first CR.RESULTS: In the overall pairwise compared AML population, the projected 7-year overall survival (OS) rate was 58% for the alloSCT and 46% for the conventional postremission treatment group (P = .037; log-rank test). Relapse-free survival (RFS) was 52% in the alloSCT group compared with 33% in the control group (P < .001). OS was significantly better for alloSCT in patient subgroups with nonfavorable chromosomal aberrations, patients older than 45 years, and patients with secondary AML or high-risk myelodysplastic syndrome. For the entire patient cohort, postremission therapy was an independent factor for OS (hazard ratio, 0.66; 95% CI, 0.49 to 0.89 for alloSCT v conventional chemotherapy), among age, cytogenetics, and bone marrow blasts after the first induction cycle.CONCLUSION: AlloSCT is the most potent postremission therapy for AML and is particularly active for patients 45 to 59 years of age and/or those with high-risk cytogenetics.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Female
KW - Hematopoietic Stem Cell Transplantation
KW - Humans
KW - Kaplan-Meier Estimate
KW - Leukemia, Myeloid, Acute
KW - Male
KW - Matched-Pair Analysis
KW - Middle Aged
KW - Prospective Studies
KW - Remission Induction
KW - Transplantation, Homologous
KW - Treatment Outcome
U2 - 10.1200/JCO.2013.50.5768
DO - 10.1200/JCO.2013.50.5768
M3 - SCORING: Journal article
C2 - 24366930
VL - 32
SP - 288
EP - 296
JO - J CLIN ONCOL
JF - J CLIN ONCOL
SN - 0732-183X
IS - 4
ER -