Allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies after dose-escalated treosulfan/fludarabine conditioning.

  • Jochen Casper
  • Daniel Wolff
  • Wolfgang Knauf
  • Igor W Blau
  • Tapani Ruutu
  • Liisa Volin
  • Hannes Wandt
  • Kerstin Schäfer-Eckart
  • Jerzy Holowiecki
  • Sebastian Giebel
  • Johan Aschan
  • Axel R. Zander
  • Nicolaus Kröger
  • Inken Hilgendorf
  • Joachim Baumgart
  • Heidrun A Mylius
  • Uwe Pichlmeier
  • Mathias Freund

Abstract

Treosulfan was introduced recently as a conditioning agent for allogeneic blood stem-cell transplantation. The favorable nonhematologic toxicity profile at 3 x 10 g/m(2) was the basis for dose escalation in this prospective, multicenter trial.

Bibliographical data

Original languageGerman
Article number20
ISSN0732-183X
Publication statusPublished - 2010
pubmed 20498405