Allogeneic hematopoietic cell transplantation in patients with chronic phase chronic myeloid leukemia in the era of third generation tyrosine kinase inhibitors: A retrospective study by the chronic malignancies working party of the EBMT
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Allogeneic hematopoietic cell transplantation in patients with chronic phase chronic myeloid leukemia in the era of third generation tyrosine kinase inhibitors: A retrospective study by the chronic malignancies working party of the EBMT. / Chalandon, Yves; Sbianchi, Giulia; Gras, Luuk; Koster, Linda; Apperley, Jane; Byrne, Jenny; Salmenniemi, Urpu; Sengeloev, Henrik; Aljurf, Mahmoud; Helbig, Grzegorz; Kinsella, Francesca; Choi, Goda; Reményi, Péter; Snowden, John A; Robin, Marie; Lenhoff, Stig; Mielke, Stephan; Passweg, Jakob; Broers, Annoek E C; Kröger, Nicolaus; Yegin, Zeynep Arzu; Tan, Sen Mui; Hayden, Patrick J; McLornan, Donal P; Yakoub-Agha, Ibrahim; Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation (EBMT).
In: AM J HEMATOL, Vol. 98, No. 1, 01.2023, p. 112-121.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Allogeneic hematopoietic cell transplantation in patients with chronic phase chronic myeloid leukemia in the era of third generation tyrosine kinase inhibitors: A retrospective study by the chronic malignancies working party of the EBMT
AU - Chalandon, Yves
AU - Sbianchi, Giulia
AU - Gras, Luuk
AU - Koster, Linda
AU - Apperley, Jane
AU - Byrne, Jenny
AU - Salmenniemi, Urpu
AU - Sengeloev, Henrik
AU - Aljurf, Mahmoud
AU - Helbig, Grzegorz
AU - Kinsella, Francesca
AU - Choi, Goda
AU - Reményi, Péter
AU - Snowden, John A
AU - Robin, Marie
AU - Lenhoff, Stig
AU - Mielke, Stephan
AU - Passweg, Jakob
AU - Broers, Annoek E C
AU - Kröger, Nicolaus
AU - Yegin, Zeynep Arzu
AU - Tan, Sen Mui
AU - Hayden, Patrick J
AU - McLornan, Donal P
AU - Yakoub-Agha, Ibrahim
AU - Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
N1 - © 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - Following the introduction of tyrosine kinase inhibitors (TKI), the number of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for chronic phase (CP) chronic myeloid leukemia (CML) has dramatically decreased. Imatinib was the first TKI introduced to the clinical arena, predominantly utilized in the first line setting. In cases of insufficient response, resistance, or intolerance, CML patients can subsequently be treated with either a second or third generation TKI. Between 2006 and 2016, we analyzed the impact of the use of 1, 2, or 3 TKI prior to allo-HCT for CP CML in 904 patients. A total of 323-, 371-, and 210 patients had 1, 2, or 3 TKI prior to transplant, respectively; imatinib (n = 778), dasatinib (n = 508), nilotinib (n = 353), bosutinib (n = 12), and ponatinib (n = 44). The majority had imatinib as first TKI (n = 747, 96%). Transplants were performed in CP1, n = 549, CP2, n = 306, and CP3, n = 49. With a median follow-up of 52 months, 5-year OS for the entire population was 64.4% (95% CI 60.9-67.9%), PFS 50% (95% CI 46.3-53.7%), RI 28.7% (95% CI 25.4-32.0%), and NRM 21.3% (95% CI 18.3-24.2%). No difference in OS, PFS, RI, or NRM was evident related to the number of TKI prior to allo-HCT or to the type of TKI (p = ns). Significant factors influencing OS and PFS were > CP1 versus CP1 and Karnofsky performance (KPS) score > 80 versus ≤80, highlighting CP1 patients undergoing allo-HCT have improved survival compared to >CP1 and the importance of careful allo-HCT candidate selection.
AB - Following the introduction of tyrosine kinase inhibitors (TKI), the number of patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) for chronic phase (CP) chronic myeloid leukemia (CML) has dramatically decreased. Imatinib was the first TKI introduced to the clinical arena, predominantly utilized in the first line setting. In cases of insufficient response, resistance, or intolerance, CML patients can subsequently be treated with either a second or third generation TKI. Between 2006 and 2016, we analyzed the impact of the use of 1, 2, or 3 TKI prior to allo-HCT for CP CML in 904 patients. A total of 323-, 371-, and 210 patients had 1, 2, or 3 TKI prior to transplant, respectively; imatinib (n = 778), dasatinib (n = 508), nilotinib (n = 353), bosutinib (n = 12), and ponatinib (n = 44). The majority had imatinib as first TKI (n = 747, 96%). Transplants were performed in CP1, n = 549, CP2, n = 306, and CP3, n = 49. With a median follow-up of 52 months, 5-year OS for the entire population was 64.4% (95% CI 60.9-67.9%), PFS 50% (95% CI 46.3-53.7%), RI 28.7% (95% CI 25.4-32.0%), and NRM 21.3% (95% CI 18.3-24.2%). No difference in OS, PFS, RI, or NRM was evident related to the number of TKI prior to allo-HCT or to the type of TKI (p = ns). Significant factors influencing OS and PFS were > CP1 versus CP1 and Karnofsky performance (KPS) score > 80 versus ≤80, highlighting CP1 patients undergoing allo-HCT have improved survival compared to >CP1 and the importance of careful allo-HCT candidate selection.
U2 - 10.1002/ajh.26764
DO - 10.1002/ajh.26764
M3 - SCORING: Journal article
C2 - 36266607
VL - 98
SP - 112
EP - 121
JO - AM J HEMATOL
JF - AM J HEMATOL
SN - 0361-8609
IS - 1
ER -
