AllergoOncology - the impact of allergy in oncology: EAACI position paper

TY - JOUR

T1 - AllergoOncology - the impact of allergy in oncology: EAACI position paper

AU - Jensen-Jarolim, E

AU - Bax, H J

AU - Bianchini, R

AU - Capron, M

AU - Corrigan, C

AU - Castells, M

AU - Dombrowicz, D

AU - Daniels-Wells, T R

AU - Fazekas, J

AU - Fiebiger, E

AU - Gatault, S

AU - Gould, H J

AU - Janda, J

AU - Josephs, D H

AU - Karagiannis, P

AU - Levi-Schaffer, F

AU - Meshcheryakova, A

AU - Mechtcheriakova, D

AU - Mekori, Y

AU - Mungenast, F

AU - Nigro, E A

AU - Penichet, M L

AU - Redegeld, F

AU - Saul, L

AU - Singer, J

AU - Spicer, J F

AU - Siccardi, A G

AU - Spillner, E

AU - Turner, M C

AU - Untersmayr, E

AU - Vangelista, L

AU - Karagiannis, S N

N1 - © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd.

PY - 2017/6

Y1 - 2017/6

N2 - Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

AB - Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

U2 - 10.1111/all.13119

DO - 10.1111/all.13119

M3 - SCORING: Journal article

C2 - 28032353

VL - 72

SP - 866

EP - 887

JO - ALLERGY

JF - ALLERGY

SN - 0105-4538

IS - 6

ER -