Research ExplorerPublicationsAllelic loss of Hox11L1 gene locus predicts outcome of gastr...

Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.

Standard

Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors. / Kaifi, Jussuf; Wagner, Meike; Schurr, Paulus; Wachowiak, Robin; Reichelt, Uta; Yekebas, Emre F; Mann, Oliver; Vashist, Yogesh; Kleinhans, Helge; Link, Bjoern-Christian; Strate, Tim; Kalinin, Viacheslav; Izbicki, Jakob R.

In: ONCOL REP, Vol. 16, No. 4, 4, 2006, p. 915-919.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaifi, J, Wagner, M, Schurr, P, Wachowiak, R, Reichelt, U, Yekebas, EF, Mann, O, Vashist, Y, Kleinhans, H, Link, B-C, Strate, T, Kalinin, V & Izbicki, JR 2006, 'Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.', ONCOL REP, vol. 16, no. 4, 4, pp. 915-919. <http://www.ncbi.nlm.nih.gov/pubmed/16969514?dopt=Citation>

APA

Kaifi, J., Wagner, M., Schurr, P., Wachowiak, R., Reichelt, U., Yekebas, E. F., Mann, O., Vashist, Y., Kleinhans, H., Link, B-C., Strate, T., Kalinin, V., & Izbicki, J. R. (2006). Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors. ONCOL REP, 16(4), 915-919. [4]. http://www.ncbi.nlm.nih.gov/pubmed/16969514?dopt=Citation

Vancouver

Kaifi J, Wagner M, Schurr P, Wachowiak R, Reichelt U, Yekebas EF et al. Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors. ONCOL REP. 2006;16(4):915-919. 4.

Bibtex

@article{9f229dbe207446a69a19bdd76fd3b930,
title = "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.",
abstract = "Loss of heterozygosity (LOH) in tumors has been described to have prognostic impact. Hox11L1 gene, located on chromosome 2, has a role in proliferation of neuronal myenteric Cajal cells being the progenitor cells of GISTs. The aim was to examine the frequency and prognostic value of allelic loss of Hox11L1 gene locus in GISTs. Tumor and control DNA of 72 GIST patients was extracted after microdissection from tissue sections. Patients underwent surgery between 1992 and 2003 and were histopathologically reclassified. Microsatellite marker D2S286 on chromosomes 2 near Hox11L1 gene locus was used for detection of LOH by PCR and capillary electrophoresis. Survival was calculated by Kaplan-Meier plots. LOH was found in 7 (10%) of 72 GISTs. Fifty-four (75%) cases did not show LOH. Eleven (15%) were homozygous and consequently non-informative. Survival analysis (n=59) revealed a significantly worse tumor-specific and relapse-free survival for GIST patients with LOH in the tumor by univariate analysis (p",
author = "Jussuf Kaifi and Meike Wagner and Paulus Schurr and Robin Wachowiak and Uta Reichelt and Yekebas, {Emre F} and Oliver Mann and Yogesh Vashist and Helge Kleinhans and Bjoern-Christian Link and Tim Strate and Viacheslav Kalinin and Izbicki, {Jakob R}",
year = "2006",
language = "Deutsch",
volume = "16",
pages = "915--919",
journal = "ONCOL REP",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors.

AU - Kaifi, Jussuf

AU - Wagner, Meike

AU - Schurr, Paulus

AU - Wachowiak, Robin

AU - Reichelt, Uta

AU - Yekebas, Emre F

AU - Mann, Oliver

AU - Vashist, Yogesh

AU - Kleinhans, Helge

AU - Link, Bjoern-Christian

AU - Strate, Tim

AU - Kalinin, Viacheslav

AU - Izbicki, Jakob R

PY - 2006

Y1 - 2006

N2 - Loss of heterozygosity (LOH) in tumors has been described to have prognostic impact. Hox11L1 gene, located on chromosome 2, has a role in proliferation of neuronal myenteric Cajal cells being the progenitor cells of GISTs. The aim was to examine the frequency and prognostic value of allelic loss of Hox11L1 gene locus in GISTs. Tumor and control DNA of 72 GIST patients was extracted after microdissection from tissue sections. Patients underwent surgery between 1992 and 2003 and were histopathologically reclassified. Microsatellite marker D2S286 on chromosomes 2 near Hox11L1 gene locus was used for detection of LOH by PCR and capillary electrophoresis. Survival was calculated by Kaplan-Meier plots. LOH was found in 7 (10%) of 72 GISTs. Fifty-four (75%) cases did not show LOH. Eleven (15%) were homozygous and consequently non-informative. Survival analysis (n=59) revealed a significantly worse tumor-specific and relapse-free survival for GIST patients with LOH in the tumor by univariate analysis (p

AB - Loss of heterozygosity (LOH) in tumors has been described to have prognostic impact. Hox11L1 gene, located on chromosome 2, has a role in proliferation of neuronal myenteric Cajal cells being the progenitor cells of GISTs. The aim was to examine the frequency and prognostic value of allelic loss of Hox11L1 gene locus in GISTs. Tumor and control DNA of 72 GIST patients was extracted after microdissection from tissue sections. Patients underwent surgery between 1992 and 2003 and were histopathologically reclassified. Microsatellite marker D2S286 on chromosomes 2 near Hox11L1 gene locus was used for detection of LOH by PCR and capillary electrophoresis. Survival was calculated by Kaplan-Meier plots. LOH was found in 7 (10%) of 72 GISTs. Fifty-four (75%) cases did not show LOH. Eleven (15%) were homozygous and consequently non-informative. Survival analysis (n=59) revealed a significantly worse tumor-specific and relapse-free survival for GIST patients with LOH in the tumor by univariate analysis (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 16

SP - 915

EP - 919

JO - ONCOL REP

JF - ONCOL REP

SN - 1021-335X

IS - 4

M1 - 4

ER -