Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.

Jakob Cramer; Frank P Mockenhaupt; Ingo Möhl; Sabine Dittrich; Ekkehardt Dietz; Rowland N Otchwemah; Stephan Ehrhardt; Ulrich Bienzle; Tomas Jelinek

Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.

Standard

Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children. / Cramer, Jakob; Mockenhaupt, Frank P; Möhl, Ingo; Dittrich, Sabine; Dietz, Ekkehardt; Otchwemah, Rowland N; Ehrhardt, Stephan; Bienzle, Ulrich; Jelinek, Tomas.

In: MALARIA J, Vol. 3, 2004, p. 11.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cramer, J, Mockenhaupt, FP, Möhl, I, Dittrich, S, Dietz, E, Otchwemah, RN, Ehrhardt, S, Bienzle, U & Jelinek, T 2004, 'Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.', MALARIA J, vol. 3, pp. 11. <http://www.ncbi.nlm.nih.gov/pubmed/15140262?dopt=Citation>

APA

Cramer, J., Mockenhaupt, F. P., Möhl, I., Dittrich, S., Dietz, E., Otchwemah, R. N., Ehrhardt, S., Bienzle, U., & Jelinek, T. (2004). Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children. MALARIA J, 3, 11. http://www.ncbi.nlm.nih.gov/pubmed/15140262?dopt=Citation

Vancouver

Cramer J, Mockenhaupt FP, Möhl I, Dittrich S, Dietz E, Otchwemah RN et al. Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children. MALARIA J. 2004;3:11.

Bibtex

@article{22658858d3a744a69836b3c1ef6ef285,

title = "Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.",

abstract = "The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore, plays a crucial role in cell invasion. Dimorphic allele segments have been found in its encoding gene with a 342 bp segment present in FCR-3 strains (F-segment) and a 423 bp segment in CAMP strains (C-segment). Possible associations of the dimorphism with severe malaria have been analysed in a case-control study in northern Ghana.",

author = "Jakob Cramer and Mockenhaupt, {Frank P} and Ingo M{\"o}hl and Sabine Dittrich and Ekkehardt Dietz and Otchwemah, {Rowland N} and Stephan Ehrhardt and Ulrich Bienzle and Tomas Jelinek",

year = "2004",

language = "Deutsch",

volume = "3",

pages = "11",

journal = "MALARIA J",

issn = "1475-2875",

publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Allelic dimorphism of the erythrocyte binding antigen-175 (eba-175) gene of Plasmodium falciparum and severe malaria: Significant association of the C-segment with fatal outcome in Ghanaian children.

AU - Cramer, Jakob

AU - Mockenhaupt, Frank P

AU - Möhl, Ingo

AU - Dittrich, Sabine

AU - Dietz, Ekkehardt

AU - Otchwemah, Rowland N

AU - Ehrhardt, Stephan

AU - Bienzle, Ulrich

AU - Jelinek, Tomas

PY - 2004

Y1 - 2004

N2 - The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore, plays a crucial role in cell invasion. Dimorphic allele segments have been found in its encoding gene with a 342 bp segment present in FCR-3 strains (F-segment) and a 423 bp segment in CAMP strains (C-segment). Possible associations of the dimorphism with severe malaria have been analysed in a case-control study in northern Ghana.

AB - The erythrocyte binding antigen-175 (EBA-175) on Plasmodium falciparum merozoites mediates sialic acid dependent binding to glycophorin A on host erythrocytes and, therefore, plays a crucial role in cell invasion. Dimorphic allele segments have been found in its encoding gene with a 342 bp segment present in FCR-3 strains (F-segment) and a 423 bp segment in CAMP strains (C-segment). Possible associations of the dimorphism with severe malaria have been analysed in a case-control study in northern Ghana.

M3 - SCORING: Zeitschriftenaufsatz

VL - 3

SP - 11

JO - MALARIA J

JF - MALARIA J

SN - 1475-2875

ER -