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Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide

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Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide. / Shah, Neil D; Ventura-Cots, Meritxell; Abraldes, Juan G; Alboraie, Mohamed; Alfadhli, Ahmad; Argemi, Josepmaria; Badia-Aranda, Ester; Soler, Enrique Arus; Barritt, A Sidney; Bessone, Fernando; Biryukova, Marina; Carrilho, Flair J; Fernández, Marlen Castellanos; Guiridi, Zaily Dorta; El Kassas, Mohamed; Eng-Kiong, Teo; Farias, Alberto; George, Jacob; Gui, Wenfang; Harichander-Thurairajah, Prem; Hsiang, John Chen; Husić-Selimovic, Azra; Isakov, Vasily; Karoney, Mercy; Kim, Won; Kluwe, Johannes; Kochhar, Rakesh; Dhaka, Narendra; Costa, Pedro Marques; Nabeshima, Mariana A; Ono, Suzane K; Reis, Daniela; Rodil, Agustina; Domech, Caridad Ruenes; Sáez-Royuela, Federico; Scheurich, Christoph; Siow, Way; Sivac-Burina, Nadja; Dos Santos Traquino, Edna Solange; Some, Fatma; Spreckic, Sanjin; Tan, Shiyun; Vorobioff, Julio; Wandera, Andrew; Wu, Pengbo; Yakoub, Mohamed; Yang, Ling; Yu, Yuanjie; Zahiragic, Nerma; Zhang, Chaoqun; Cortez-Pinto, Helena; Bataller, Ramon.

In: CLIN GASTROENTEROL H, Vol. 17, No. 11, 10.2019, p. 2320-2329.e12.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Shah, ND, Ventura-Cots, M, Abraldes, JG, Alboraie, M, Alfadhli, A, Argemi, J, Badia-Aranda, E, Soler, EA, Barritt, AS, Bessone, F, Biryukova, M, Carrilho, FJ, Fernández, MC, Guiridi, ZD, El Kassas, M, Eng-Kiong, T, Farias, A, George, J, Gui, W, Harichander-Thurairajah, P, Hsiang, JC, Husić-Selimovic, A, Isakov, V, Karoney, M, Kim, W, Kluwe, J, Kochhar, R, Dhaka, N, Costa, PM, Nabeshima, MA, Ono, SK, Reis, D, Rodil, A, Domech, CR, Sáez-Royuela, F, Scheurich, C, Siow, W, Sivac-Burina, N, Dos Santos Traquino, ES, Some, F, Spreckic, S, Tan, S, Vorobioff, J, Wandera, A, Wu, P, Yakoub, M, Yang, L, Yu, Y, Zahiragic, N, Zhang, C, Cortez-Pinto, H & Bataller, R 2019, 'Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide', CLIN GASTROENTEROL H, vol. 17, no. 11, pp. 2320-2329.e12. https://doi.org/10.1016/j.cgh.2019.01.026

APA

Shah, N. D., Ventura-Cots, M., Abraldes, J. G., Alboraie, M., Alfadhli, A., Argemi, J., Badia-Aranda, E., Soler, E. A., Barritt, A. S., Bessone, F., Biryukova, M., Carrilho, F. J., Fernández, M. C., Guiridi, Z. D., El Kassas, M., Eng-Kiong, T., Farias, A., George, J., Gui, W., ... Bataller, R. (2019). Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide. CLIN GASTROENTEROL H, 17(11), 2320-2329.e12. https://doi.org/10.1016/j.cgh.2019.01.026

Vancouver

Shah ND, Ventura-Cots M, Abraldes JG, Alboraie M, Alfadhli A, Argemi J et al. Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide. CLIN GASTROENTEROL H. 2019 Oct;17(11):2320-2329.e12. https://doi.org/10.1016/j.cgh.2019.01.026

Bibtex

@article{7ab77e59cb3d4db8ba44f4694dd37862,
title = "Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide",
abstract = "BACKGROUND & AIMS: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies.METHODS: We performed a cross-sectional study of 3453 consecutive patients with either early or advanced liver disease (1699 patients with early and 1754 with advanced liver disease) seen at 17 tertiary care liver or gastrointestinal units worldwide, from August 2015 through March 2017. We collected anthropometric, etiology, and clinical information, as well as and model for end-stage liver disease scores. We used unconditional logistic regression to estimate the odds ratios for evaluation at late stages of the disease progression.RESULTS: Of the patients analyzed, 81% had 1 etiology of liver disease and 17% had 2 etiologies of liver disease. Of patients seen at early stages for a single etiology, 31% had HCV infection, 21% had hepatitis B virus infection, and 17% had nonalcoholic fatty liver disease, whereas only 3.8% had ALD. In contrast, 29% of patients seen for advanced disease had ALD. Patients with ALD were more likely to be seen at specialized centers, with advanced-stage disease, compared with patients with HCV-associated liver disease (odds ratio, 14.1; 95% CI, 10.5-18.9; P < .001). Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. These patients had significantly more visits to health care providers, with more advanced disease, compared with patients without excess alcohol use. The mean model for end-stage liver disease score for patients with advanced ALD (score, 16) was higher than for patients with advanced liver disease not associated with excess alcohol use (score, 13) (P < .01).CONCLUSIONS: In a cross-sectional analysis of patients with liver disease worldwide, we found that patients with ALD are seen with more advanced-stage disease than patients with HCV-associated liver disease. Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. Early detection and referral programs are needed for patients with ALD worldwide.",
keywords = "Journal Article",
author = "Shah, {Neil D} and Meritxell Ventura-Cots and Abraldes, {Juan G} and Mohamed Alboraie and Ahmad Alfadhli and Josepmaria Argemi and Ester Badia-Aranda and Soler, {Enrique Arus} and Barritt, {A Sidney} and Fernando Bessone and Marina Biryukova and Carrilho, {Flair J} and Fern{\'a}ndez, {Marlen Castellanos} and Guiridi, {Zaily Dorta} and {El Kassas}, Mohamed and Teo Eng-Kiong and Alberto Farias and Jacob George and Wenfang Gui and Prem Harichander-Thurairajah and Hsiang, {John Chen} and Azra Husi{\'c}-Selimovic and Vasily Isakov and Mercy Karoney and Won Kim and Johannes Kluwe and Rakesh Kochhar and Narendra Dhaka and Costa, {Pedro Marques} and Nabeshima, {Mariana A} and Ono, {Suzane K} and Daniela Reis and Agustina Rodil and Domech, {Caridad Ruenes} and Federico S{\'a}ez-Royuela and Christoph Scheurich and Way Siow and Nadja Sivac-Burina and {Dos Santos Traquino}, {Edna Solange} and Fatma Some and Sanjin Spreckic and Shiyun Tan and Julio Vorobioff and Andrew Wandera and Pengbo Wu and Mohamed Yakoub and Ling Yang and Yuanjie Yu and Nerma Zahiragic and Chaoqun Zhang and Helena Cortez-Pinto and Ramon Bataller",
note = "Copyright {\textcopyright} 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = oct,
doi = "10.1016/j.cgh.2019.01.026",
language = "English",
volume = "17",
pages = "2320--2329.e12",
journal = "CLIN GASTROENTEROL H",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide

AU - Shah, Neil D

AU - Ventura-Cots, Meritxell

AU - Abraldes, Juan G

AU - Alboraie, Mohamed

AU - Alfadhli, Ahmad

AU - Argemi, Josepmaria

AU - Badia-Aranda, Ester

AU - Soler, Enrique Arus

AU - Barritt, A Sidney

AU - Bessone, Fernando

AU - Biryukova, Marina

AU - Carrilho, Flair J

AU - Fernández, Marlen Castellanos

AU - Guiridi, Zaily Dorta

AU - El Kassas, Mohamed

AU - Eng-Kiong, Teo

AU - Farias, Alberto

AU - George, Jacob

AU - Gui, Wenfang

AU - Harichander-Thurairajah, Prem

AU - Hsiang, John Chen

AU - Husić-Selimovic, Azra

AU - Isakov, Vasily

AU - Karoney, Mercy

AU - Kim, Won

AU - Kluwe, Johannes

AU - Kochhar, Rakesh

AU - Dhaka, Narendra

AU - Costa, Pedro Marques

AU - Nabeshima, Mariana A

AU - Ono, Suzane K

AU - Reis, Daniela

AU - Rodil, Agustina

AU - Domech, Caridad Ruenes

AU - Sáez-Royuela, Federico

AU - Scheurich, Christoph

AU - Siow, Way

AU - Sivac-Burina, Nadja

AU - Dos Santos Traquino, Edna Solange

AU - Some, Fatma

AU - Spreckic, Sanjin

AU - Tan, Shiyun

AU - Vorobioff, Julio

AU - Wandera, Andrew

AU - Wu, Pengbo

AU - Yakoub, Mohamed

AU - Yang, Ling

AU - Yu, Yuanjie

AU - Zahiragic, Nerma

AU - Zhang, Chaoqun

AU - Cortez-Pinto, Helena

AU - Bataller, Ramon

N1 - Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND & AIMS: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies.METHODS: We performed a cross-sectional study of 3453 consecutive patients with either early or advanced liver disease (1699 patients with early and 1754 with advanced liver disease) seen at 17 tertiary care liver or gastrointestinal units worldwide, from August 2015 through March 2017. We collected anthropometric, etiology, and clinical information, as well as and model for end-stage liver disease scores. We used unconditional logistic regression to estimate the odds ratios for evaluation at late stages of the disease progression.RESULTS: Of the patients analyzed, 81% had 1 etiology of liver disease and 17% had 2 etiologies of liver disease. Of patients seen at early stages for a single etiology, 31% had HCV infection, 21% had hepatitis B virus infection, and 17% had nonalcoholic fatty liver disease, whereas only 3.8% had ALD. In contrast, 29% of patients seen for advanced disease had ALD. Patients with ALD were more likely to be seen at specialized centers, with advanced-stage disease, compared with patients with HCV-associated liver disease (odds ratio, 14.1; 95% CI, 10.5-18.9; P < .001). Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. These patients had significantly more visits to health care providers, with more advanced disease, compared with patients without excess alcohol use. The mean model for end-stage liver disease score for patients with advanced ALD (score, 16) was higher than for patients with advanced liver disease not associated with excess alcohol use (score, 13) (P < .01).CONCLUSIONS: In a cross-sectional analysis of patients with liver disease worldwide, we found that patients with ALD are seen with more advanced-stage disease than patients with HCV-associated liver disease. Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. Early detection and referral programs are needed for patients with ALD worldwide.

AB - BACKGROUND & AIMS: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies.METHODS: We performed a cross-sectional study of 3453 consecutive patients with either early or advanced liver disease (1699 patients with early and 1754 with advanced liver disease) seen at 17 tertiary care liver or gastrointestinal units worldwide, from August 2015 through March 2017. We collected anthropometric, etiology, and clinical information, as well as and model for end-stage liver disease scores. We used unconditional logistic regression to estimate the odds ratios for evaluation at late stages of the disease progression.RESULTS: Of the patients analyzed, 81% had 1 etiology of liver disease and 17% had 2 etiologies of liver disease. Of patients seen at early stages for a single etiology, 31% had HCV infection, 21% had hepatitis B virus infection, and 17% had nonalcoholic fatty liver disease, whereas only 3.8% had ALD. In contrast, 29% of patients seen for advanced disease had ALD. Patients with ALD were more likely to be seen at specialized centers, with advanced-stage disease, compared with patients with HCV-associated liver disease (odds ratio, 14.1; 95% CI, 10.5-18.9; P < .001). Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. These patients had significantly more visits to health care providers, with more advanced disease, compared with patients without excess alcohol use. The mean model for end-stage liver disease score for patients with advanced ALD (score, 16) was higher than for patients with advanced liver disease not associated with excess alcohol use (score, 13) (P < .01).CONCLUSIONS: In a cross-sectional analysis of patients with liver disease worldwide, we found that patients with ALD are seen with more advanced-stage disease than patients with HCV-associated liver disease. Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. Early detection and referral programs are needed for patients with ALD worldwide.

KW - Journal Article

U2 - 10.1016/j.cgh.2019.01.026

DO - 10.1016/j.cgh.2019.01.026

M3 - SCORING: Journal article

C2 - 30708110

VL - 17

SP - 2320-2329.e12

JO - CLIN GASTROENTEROL H

JF - CLIN GASTROENTEROL H

SN - 1542-3565

IS - 11

ER -