Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study
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Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. / Di Castelnuovo, Augusto; Costanzo, Simona; Bonaccio, Marialaura; McElduff, Patrick; Linneberg, Allan; Salomaa, Veikko; Männistö, Satu; Moitry, Marie; Ferrières, Jean; Dallongeville, Jean; Thorand, Barbara; Brenner, Hermann; Ferrario, Marco; Veronesi, Giovanni; Pettenuzzo, Emanuela; Tamosiunas, Abdonas; Njølstad, Inger; Drygas, Wojciech; Nikitin, Yuri; Söderberg, Stefan; Kee, Frank; Grassi, Guido; Westermann, Dirk; Schrage, Benedikt; Dabboura, Salim; Zeller, Tanja; Kuulasmaa, Kari; Blankenberg, Stefan; Donati, Maria Benedetta; de Gaetano, Giovanni; Iacoviello, Licia.
In: ADDICTION, Vol. 117, No. 2, 02.2022, p. 312-325.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study
AU - Di Castelnuovo, Augusto
AU - Costanzo, Simona
AU - Bonaccio, Marialaura
AU - McElduff, Patrick
AU - Linneberg, Allan
AU - Salomaa, Veikko
AU - Männistö, Satu
AU - Moitry, Marie
AU - Ferrières, Jean
AU - Dallongeville, Jean
AU - Thorand, Barbara
AU - Brenner, Hermann
AU - Ferrario, Marco
AU - Veronesi, Giovanni
AU - Pettenuzzo, Emanuela
AU - Tamosiunas, Abdonas
AU - Njølstad, Inger
AU - Drygas, Wojciech
AU - Nikitin, Yuri
AU - Söderberg, Stefan
AU - Kee, Frank
AU - Grassi, Guido
AU - Westermann, Dirk
AU - Schrage, Benedikt
AU - Dabboura, Salim
AU - Zeller, Tanja
AU - Kuulasmaa, Kari
AU - Blankenberg, Stefan
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Iacoviello, Licia
N1 - © 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
PY - 2022/2
Y1 - 2022/2
N2 - AIM: To test the association of alcohol consumption with total and cause-specific mortality risk.DESIGN: Prospective observational multi-centre population-based study.SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.PARTICIPANTS: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
AB - AIM: To test the association of alcohol consumption with total and cause-specific mortality risk.DESIGN: Prospective observational multi-centre population-based study.SETTING: Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.PARTICIPANTS: A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).MEASUREMENTS: Average alcohol intake by food frequency questionnaire, total and cause-specific mortality.FINDINGS: In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7-14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7-20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10-35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively.CONCLUSIONS: In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.
U2 - 10.1111/add.15593
DO - 10.1111/add.15593
M3 - SCORING: Journal article
C2 - 34105209
VL - 117
SP - 312
EP - 325
JO - ADDICTION
JF - ADDICTION
SN - 0965-2140
IS - 2
ER -
