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A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling

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A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling. / Subramanian, Hariharan; Nikolaev, Viacheslav O.

In: CELLS-BASEL, Vol. 12, No. 3, 436, 28.01.2023.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Subramanian, H & Nikolaev, VO 2023, 'A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling', CELLS-BASEL, vol. 12, no. 3, 436. https://doi.org/10.3390/cells12030436

APA

Subramanian, H., & Nikolaev, V. O. (2023). A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling. CELLS-BASEL, 12(3), [436]. https://doi.org/10.3390/cells12030436

Vancouver

Subramanian H, Nikolaev VO. A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling. CELLS-BASEL. 2023 Jan 28;12(3). 436. https://doi.org/10.3390/cells12030436

Bibtex

@article{c12a98f19fc9422b9f455c0ddd62f8ae,
title = "A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling",
abstract = "The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper function of those proteins is an effective potential therapeutic strategy. The calcium-handling proteins or their regulators are phosphorylated by a cAMP-dependent kinase (PKA), and thereby their activity is regulated. A-Kinase Anchoring Proteins (AKAPs) play a seminal role in orchestrating PKA and cAMP regulators in calcium handling and contractile machinery. This cAMP/PKA orchestration is crucial for the increased force and rate of contraction and relaxation of the heart in response to fight-or-flight. Knockout models and the few available preclinical models proved that the efficient targeting of AKAPs offers potential therapies tailor-made for improving defective calcium cycling. In this review, we highlight important studies that identified AKAPs and their regulatory roles in cardiac myocyte calcium cycling in health and disease.",
keywords = "Humans, A Kinase Anchor Proteins/metabolism, Calcium/metabolism, Calcium-Binding Proteins/metabolism, Heart Failure/metabolism, Myocytes, Cardiac/metabolism",
author = "Hariharan Subramanian and Nikolaev, {Viacheslav O}",
year = "2023",
month = jan,
day = "28",
doi = "10.3390/cells12030436",
language = "English",
volume = "12",
journal = "CELLS-BASEL",
issn = "2073-4409",
publisher = "MDPI Multidisciplinary Digital Publishing Institute",
number = "3",

}

RIS

TY - JOUR

T1 - A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling

AU - Subramanian, Hariharan

AU - Nikolaev, Viacheslav O

PY - 2023/1/28

Y1 - 2023/1/28

N2 - The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper function of those proteins is an effective potential therapeutic strategy. The calcium-handling proteins or their regulators are phosphorylated by a cAMP-dependent kinase (PKA), and thereby their activity is regulated. A-Kinase Anchoring Proteins (AKAPs) play a seminal role in orchestrating PKA and cAMP regulators in calcium handling and contractile machinery. This cAMP/PKA orchestration is crucial for the increased force and rate of contraction and relaxation of the heart in response to fight-or-flight. Knockout models and the few available preclinical models proved that the efficient targeting of AKAPs offers potential therapies tailor-made for improving defective calcium cycling. In this review, we highlight important studies that identified AKAPs and their regulatory roles in cardiac myocyte calcium cycling in health and disease.

AB - The rate of calcium cycling and calcium transient amplitude are critical determinants for the efficient contraction and relaxation of the heart. Calcium-handling proteins in the cardiac myocyte are altered in heart failure, and restoring the proper function of those proteins is an effective potential therapeutic strategy. The calcium-handling proteins or their regulators are phosphorylated by a cAMP-dependent kinase (PKA), and thereby their activity is regulated. A-Kinase Anchoring Proteins (AKAPs) play a seminal role in orchestrating PKA and cAMP regulators in calcium handling and contractile machinery. This cAMP/PKA orchestration is crucial for the increased force and rate of contraction and relaxation of the heart in response to fight-or-flight. Knockout models and the few available preclinical models proved that the efficient targeting of AKAPs offers potential therapies tailor-made for improving defective calcium cycling. In this review, we highlight important studies that identified AKAPs and their regulatory roles in cardiac myocyte calcium cycling in health and disease.

KW - Humans

KW - A Kinase Anchor Proteins/metabolism

KW - Calcium/metabolism

KW - Calcium-Binding Proteins/metabolism

KW - Heart Failure/metabolism

KW - Myocytes, Cardiac/metabolism

U2 - 10.3390/cells12030436

DO - 10.3390/cells12030436

M3 - SCORING: Review article

C2 - 36766777

VL - 12

JO - CELLS-BASEL

JF - CELLS-BASEL

SN - 2073-4409

IS - 3

M1 - 436

ER -