Research ExplorerPublicationsAirway obstruction and lung hyperinflation in COPD are linke...

Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling

Standard

Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling. / Alter, Peter; Watz, Henrik; Kahnert, Kathrin; Pfeifer, Michael; Randerath, Winfried J; Andreas, Stefan; Waschki, Benjamin; Kleibrink, Björn E; Welte, Tobias; Bals, Robert; Schulz, Holger; Biertz, Frank; Young, David; Vogelmeier, Claus F; Jörres, Rudolf A.

In: RESP MED, Vol. 137, 04.2018, p. 14-22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Alter, P, Watz, H, Kahnert, K, Pfeifer, M, Randerath, WJ, Andreas, S, Waschki, B, Kleibrink, BE, Welte, T, Bals, R, Schulz, H, Biertz, F, Young, D, Vogelmeier, CF & Jörres, RA 2018, 'Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling', RESP MED, vol. 137, pp. 14-22. https://doi.org/10.1016/j.rmed.2018.02.011

APA

Alter, P., Watz, H., Kahnert, K., Pfeifer, M., Randerath, W. J., Andreas, S., Waschki, B., Kleibrink, B. E., Welte, T., Bals, R., Schulz, H., Biertz, F., Young, D., Vogelmeier, C. F., & Jörres, R. A. (2018). Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling. RESP MED, 137, 14-22. https://doi.org/10.1016/j.rmed.2018.02.011

Vancouver

Alter P, Watz H, Kahnert K, Pfeifer M, Randerath WJ, Andreas S et al. Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling. RESP MED. 2018 Apr;137:14-22. https://doi.org/10.1016/j.rmed.2018.02.011

Bibtex

@article{ef8838298bfc4aa1ba776f75f8a41fd1,
title = "Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling",
abstract = "AIMS: Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are thought to be linked through various factors. We aimed to assess the relationship between airway obstruction, lung hyperinflation and diastolic filling in COPD.METHODS: The study population was a subset of the COPD cohort COSYCONET. Echocardiographic parameters included the left atrial diameter (LA), early (E) and late (A) transmitral flow, mitral annulus velocity (e'), E wave deceleration time (E[dt]), and isovolumic relaxation time (IVRT). We quantified the effect of various predictors including forced expiratory volume in 1 s (FEV1) and intrathoracic gas volume (ITGV) on the echocardiographic parameters by multiple linear regression and integrated the relationships into a path analysis model.RESULTS: A total of 615 COPD patients were included (mean FEV1 52.6% predicted). In addition to influences of age, BMI and blood pressure, ITGV was positively related to e'-septal and negatively to LA, FEV1 positively to E(dt) (p < 0.05 each). The effect of predictors was most pronounced for LA, e'-septal and E(dt), and less for E/A, IVRT and E/e'. Path analysis was used to take into account the additional relationships between the echocardiographic parameters themselves, demonstrating that their associations with the predictors were maintained and robust.CONCLUSIONS: Airway obstruction and lung hyperinflation were significantly associated with cardiac diastolic filling in patients with COPD, suggesting a decreased preload rather than an inherently impaired myocardial relaxation itself. This suggests that a reduction in obstruction and hyperinflation could help to improve cardiac filling.",
keywords = "Aged, Airway Obstruction/physiopathology, Blood Pressure/physiology, Body Mass Index, Cross-Sectional Studies, Diastole/physiology, Echocardiography/methods, Female, Forced Expiratory Volume/physiology, Heart Failure/physiopathology, Humans, Lung/physiopathology, Male, Middle Aged, Prevalence, Prospective Studies, Pulmonary Disease, Chronic Obstructive/complications, Respiratory Function Tests/methods, Ventricular Dysfunction, Left/diagnostic imaging",
author = "Peter Alter and Henrik Watz and Kathrin Kahnert and Michael Pfeifer and Randerath, {Winfried J} and Stefan Andreas and Benjamin Waschki and Kleibrink, {Bj{\"o}rn E} and Tobias Welte and Robert Bals and Holger Schulz and Frank Biertz and David Young and Vogelmeier, {Claus F} and J{\"o}rres, {Rudolf A}",
note = "Copyright {\textcopyright} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = apr,
doi = "10.1016/j.rmed.2018.02.011",
language = "English",
volume = "137",
pages = "14--22",
journal = "RESP MED",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",

}

RIS

TY - JOUR

T1 - Airway obstruction and lung hyperinflation in COPD are linked to an impaired left ventricular diastolic filling

AU - Alter, Peter

AU - Watz, Henrik

AU - Kahnert, Kathrin

AU - Pfeifer, Michael

AU - Randerath, Winfried J

AU - Andreas, Stefan

AU - Waschki, Benjamin

AU - Kleibrink, Björn E

AU - Welte, Tobias

AU - Bals, Robert

AU - Schulz, Holger

AU - Biertz, Frank

AU - Young, David

AU - Vogelmeier, Claus F

AU - Jörres, Rudolf A

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/4

Y1 - 2018/4

N2 - AIMS: Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are thought to be linked through various factors. We aimed to assess the relationship between airway obstruction, lung hyperinflation and diastolic filling in COPD.METHODS: The study population was a subset of the COPD cohort COSYCONET. Echocardiographic parameters included the left atrial diameter (LA), early (E) and late (A) transmitral flow, mitral annulus velocity (e'), E wave deceleration time (E[dt]), and isovolumic relaxation time (IVRT). We quantified the effect of various predictors including forced expiratory volume in 1 s (FEV1) and intrathoracic gas volume (ITGV) on the echocardiographic parameters by multiple linear regression and integrated the relationships into a path analysis model.RESULTS: A total of 615 COPD patients were included (mean FEV1 52.6% predicted). In addition to influences of age, BMI and blood pressure, ITGV was positively related to e'-septal and negatively to LA, FEV1 positively to E(dt) (p < 0.05 each). The effect of predictors was most pronounced for LA, e'-septal and E(dt), and less for E/A, IVRT and E/e'. Path analysis was used to take into account the additional relationships between the echocardiographic parameters themselves, demonstrating that their associations with the predictors were maintained and robust.CONCLUSIONS: Airway obstruction and lung hyperinflation were significantly associated with cardiac diastolic filling in patients with COPD, suggesting a decreased preload rather than an inherently impaired myocardial relaxation itself. This suggests that a reduction in obstruction and hyperinflation could help to improve cardiac filling.

AB - AIMS: Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are thought to be linked through various factors. We aimed to assess the relationship between airway obstruction, lung hyperinflation and diastolic filling in COPD.METHODS: The study population was a subset of the COPD cohort COSYCONET. Echocardiographic parameters included the left atrial diameter (LA), early (E) and late (A) transmitral flow, mitral annulus velocity (e'), E wave deceleration time (E[dt]), and isovolumic relaxation time (IVRT). We quantified the effect of various predictors including forced expiratory volume in 1 s (FEV1) and intrathoracic gas volume (ITGV) on the echocardiographic parameters by multiple linear regression and integrated the relationships into a path analysis model.RESULTS: A total of 615 COPD patients were included (mean FEV1 52.6% predicted). In addition to influences of age, BMI and blood pressure, ITGV was positively related to e'-septal and negatively to LA, FEV1 positively to E(dt) (p < 0.05 each). The effect of predictors was most pronounced for LA, e'-septal and E(dt), and less for E/A, IVRT and E/e'. Path analysis was used to take into account the additional relationships between the echocardiographic parameters themselves, demonstrating that their associations with the predictors were maintained and robust.CONCLUSIONS: Airway obstruction and lung hyperinflation were significantly associated with cardiac diastolic filling in patients with COPD, suggesting a decreased preload rather than an inherently impaired myocardial relaxation itself. This suggests that a reduction in obstruction and hyperinflation could help to improve cardiac filling.

KW - Aged

KW - Airway Obstruction/physiopathology

KW - Blood Pressure/physiology

KW - Body Mass Index

KW - Cross-Sectional Studies

KW - Diastole/physiology

KW - Echocardiography/methods

KW - Female

KW - Forced Expiratory Volume/physiology

KW - Heart Failure/physiopathology

KW - Humans

KW - Lung/physiopathology

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Prospective Studies

KW - Pulmonary Disease, Chronic Obstructive/complications

KW - Respiratory Function Tests/methods

KW - Ventricular Dysfunction, Left/diagnostic imaging

U2 - 10.1016/j.rmed.2018.02.011

DO - 10.1016/j.rmed.2018.02.011

M3 - SCORING: Journal article

C2 - 29605197

VL - 137

SP - 14

EP - 22

JO - RESP MED

JF - RESP MED

SN - 0954-6111

ER -