Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium
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Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. / Morseth, Bente; Geelhoed, Bastiaan; Linneberg, Allan; Johansson, Lars; Kuulasmaa, Kari; Salomaa, Veikko; Iacoviello, Licia; Costanzo, Simona; Söderberg, Stefan; Niiranen, Teemu J; Vishram-Nielsen, Julie K K; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B; Løchen, Maja-Lisa; Zeller, Tanja; Blankenberg, Stefan; Ojeda, Francisco M; Schnabel, Renate B; MORGAM consortium.
In: OPEN HEART, Vol. 8, No. 2, e001624, 07.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium
AU - Morseth, Bente
AU - Geelhoed, Bastiaan
AU - Linneberg, Allan
AU - Johansson, Lars
AU - Kuulasmaa, Kari
AU - Salomaa, Veikko
AU - Iacoviello, Licia
AU - Costanzo, Simona
AU - Söderberg, Stefan
AU - Niiranen, Teemu J
AU - Vishram-Nielsen, Julie K K
AU - Njølstad, Inger
AU - Wilsgaard, Tom
AU - Mathiesen, Ellisiv B
AU - Løchen, Maja-Lisa
AU - Zeller, Tanja
AU - Blankenberg, Stefan
AU - Ojeda, Francisco M
AU - Schnabel, Renate B
AU - MORGAM consortium
N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/7
Y1 - 2021/7
N2 - BACKGROUND: The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.METHODS: We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.RESULTS: AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).CONCLUSION: In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.
AB - BACKGROUND: The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.METHODS: We used individual-level data (n=66 951, 49.1% men, age range 40-98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.RESULTS: AF incidence increased from 0.9 per 1000 person-years at baseline age 40-49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001).CONCLUSION: In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.
KW - Adult
KW - Age Distribution
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Atrial Fibrillation/complications
KW - Body Mass Index
KW - Europe/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Risk Assessment/methods
KW - Risk Factors
KW - Stroke/etiology
U2 - 10.1136/openhrt-2021-001624
DO - 10.1136/openhrt-2021-001624
M3 - SCORING: Journal article
C2 - 34341095
VL - 8
JO - OPEN HEART
JF - OPEN HEART
SN - 2053-3624
IS - 2
M1 - e001624
ER -
