Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model

Andreas Strube; Björn Horing; Michael Rose; Christian Büchel

doi:10.1016/j.neuron.2023.01.002

Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model

Standard

Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model. / Strube, Andreas; Horing, Björn ; Rose, Michael ; Büchel, Christian.

In: NEURON, Vol. 111, No. 7, 05.04.2023, p. 1136-1151.e7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Strube, A, Horing, B , Rose, M & Büchel, C 2023, 'Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model', NEURON, vol. 111, no. 7, pp. 1136-1151.e7. https://doi.org/10.1016/j.neuron.2023.01.002

APA

Strube, A., Horing, B., Rose, M., & Büchel, C. (2023). Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model. NEURON, 111(7), 1136-1151.e7. https://doi.org/10.1016/j.neuron.2023.01.002

Vancouver

Strube A, Horing B , Rose M , Büchel C. Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model. NEURON. 2023 Apr 5;111(7):1136-1151.e7. https://doi.org/10.1016/j.neuron.2023.01.002

Bibtex

@article{9b3f26eb0adc4042837d9f9b67f5f957,

title = "Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model",

abstract = "Agency and expectations play a crucial role in pain perception and treatment. In the Bayesian pain model, somatosensation (likelihood) and expectations (prior) are weighted by their precision and integrated to form a pain percept (posterior). Combining pain treatment with stimulus-related expectations allows the mechanistic assessment of whether agency enters this model as a shift of the prior or a relaxation of the likelihood precision. In two experiments, heat pain was sham treated either externally or by the subject, while a predictive cue was utilized to create high or low treatment expectations. Both experiments revealed additive effects and greater pain relief under self-treatment and high treatment expectations. Formal model comparisons favored a prior shift rather than a modulation of likelihood precision. Electroencephalography revealed a theta-to-alpha effect, temporally associated with expectations, which was correlated with trial-by-trial pain ratings, further supporting a prior shift through which agency exerts its influence in the Bayesian pain model.",

author = "Andreas Strube and Bj{\"o}rn Horing and Michael Rose and Christian B{\"u}chel",

year = "2023",

month = apr,

day = "5",

doi = "10.1016/j.neuron.2023.01.002",

language = "English",

volume = "111",

pages = "1136--1151.e7",

journal = "NEURON",

issn = "0896-6273",

publisher = "Cell Press",

number = "7",

}

RIS

TY - JOUR

T1 - Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model

AU - Strube, Andreas

AU - Horing, Björn

AU - Rose, Michael

AU - Büchel, Christian

PY - 2023/4/5

Y1 - 2023/4/5

N2 - Agency and expectations play a crucial role in pain perception and treatment. In the Bayesian pain model, somatosensation (likelihood) and expectations (prior) are weighted by their precision and integrated to form a pain percept (posterior). Combining pain treatment with stimulus-related expectations allows the mechanistic assessment of whether agency enters this model as a shift of the prior or a relaxation of the likelihood precision. In two experiments, heat pain was sham treated either externally or by the subject, while a predictive cue was utilized to create high or low treatment expectations. Both experiments revealed additive effects and greater pain relief under self-treatment and high treatment expectations. Formal model comparisons favored a prior shift rather than a modulation of likelihood precision. Electroencephalography revealed a theta-to-alpha effect, temporally associated with expectations, which was correlated with trial-by-trial pain ratings, further supporting a prior shift through which agency exerts its influence in the Bayesian pain model.

AB - Agency and expectations play a crucial role in pain perception and treatment. In the Bayesian pain model, somatosensation (likelihood) and expectations (prior) are weighted by their precision and integrated to form a pain percept (posterior). Combining pain treatment with stimulus-related expectations allows the mechanistic assessment of whether agency enters this model as a shift of the prior or a relaxation of the likelihood precision. In two experiments, heat pain was sham treated either externally or by the subject, while a predictive cue was utilized to create high or low treatment expectations. Both experiments revealed additive effects and greater pain relief under self-treatment and high treatment expectations. Formal model comparisons favored a prior shift rather than a modulation of likelihood precision. Electroencephalography revealed a theta-to-alpha effect, temporally associated with expectations, which was correlated with trial-by-trial pain ratings, further supporting a prior shift through which agency exerts its influence in the Bayesian pain model.

U2 - 10.1016/j.neuron.2023.01.002

DO - 10.1016/j.neuron.2023.01.002

M3 - SCORING: Journal article

C2 - 36731468

VL - 111

SP - 1136-1151.e7

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 7

ER -