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Age-dependent normal values of T2* and T2' in brain parenchyma

Standard

Age-dependent normal values of T2* and T2' in brain parenchyma. / Siemonsen, S; Finsterbusch, J; Matschke, J; Lorenzen, A; Ding, X-Q; Fiehler, J.

In: AM J NEURORADIOL, Vol. 29, No. 5, 01.05.2008, p. 950-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Siemonsen, S, Finsterbusch, J, Matschke, J, Lorenzen, A, Ding, X-Q & Fiehler, J 2008, 'Age-dependent normal values of T2* and T2' in brain parenchyma', AM J NEURORADIOL, vol. 29, no. 5, pp. 950-5. https://doi.org/10.3174/ajnr.A0951

APA

Siemonsen, S., Finsterbusch, J., Matschke, J., Lorenzen, A., Ding, X-Q., & Fiehler, J. (2008). Age-dependent normal values of T2* and T2' in brain parenchyma. AM J NEURORADIOL, 29(5), 950-5. https://doi.org/10.3174/ajnr.A0951

Vancouver

Siemonsen S, Finsterbusch J, Matschke J, Lorenzen A, Ding X-Q, Fiehler J. Age-dependent normal values of T2* and T2' in brain parenchyma. AM J NEURORADIOL. 2008 May 1;29(5):950-5. https://doi.org/10.3174/ajnr.A0951

Bibtex

@article{bad868a2e181497bacc8ff821f169048,
title = "Age-dependent normal values of T2* and T2' in brain parenchyma",
abstract = "BACKGROUND AND PURPOSE: Physiologic age-related T2* and T2' values are required as reference for comparison with disease-related deviations. In our study, T2* and T2' values (T2 values as control) were determined with MR imaging in healthy subjects to determine standard values and investigate age-related changes.MATERIALS AND METHODS: Data of 50 patients without intraparenchymal pathology and 10 acute stroke patients who underwent MR imaging including a T2 and T2* sequence with 3 echotimes were included. After calculation of T2*, T2', and T2 maps, the values of gray matter (GM) and white matter (WM) for each hemisphere were measured in 6 distinct regions of interest (ROIs).RESULTS: There was a negative correlation between age and T2* values in the caudate nucleus (r = -0.34 Pearson correlation; P = .001) and lentiform nucleus (r = -0.67; P = .001) and a positive correlation in the occipital (r = 0.41; P = .001) and subcortical (r = 0.45; P = .001) WM. An age dependency for T2' values was only found for the caudate (r = -0.35; P = .001) and lentiform nucleus (r = -0.69; P = .001). T2' values in acute stroke were lower than normal in all patients with stroke.CONCLUSION: Decrease in T2' and T2* values in GM and increase of T2* values in WM correlate with the progress of brain aging. Explanations for decreasing T2' and T2* values include iron deposition in the caudate and lentiform nucleus. In contrast to T2* values, there is no association of T2' values with the degree of leukoaraiosis. These age-dependent values can be used as a reference in neurovascular diseases and for the discussion of functional MR imaging data.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Child, Female, Germany, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values",
author = "S Siemonsen and J Finsterbusch and J Matschke and A Lorenzen and X-Q Ding and J Fiehler",
year = "2008",
month = may,
day = "1",
doi = "10.3174/ajnr.A0951",
language = "English",
volume = "29",
pages = "950--5",
journal = "AM J NEURORADIOL",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "5",

}

RIS

TY - JOUR

T1 - Age-dependent normal values of T2* and T2' in brain parenchyma

AU - Siemonsen, S

AU - Finsterbusch, J

AU - Matschke, J

AU - Lorenzen, A

AU - Ding, X-Q

AU - Fiehler, J

PY - 2008/5/1

Y1 - 2008/5/1

N2 - BACKGROUND AND PURPOSE: Physiologic age-related T2* and T2' values are required as reference for comparison with disease-related deviations. In our study, T2* and T2' values (T2 values as control) were determined with MR imaging in healthy subjects to determine standard values and investigate age-related changes.MATERIALS AND METHODS: Data of 50 patients without intraparenchymal pathology and 10 acute stroke patients who underwent MR imaging including a T2 and T2* sequence with 3 echotimes were included. After calculation of T2*, T2', and T2 maps, the values of gray matter (GM) and white matter (WM) for each hemisphere were measured in 6 distinct regions of interest (ROIs).RESULTS: There was a negative correlation between age and T2* values in the caudate nucleus (r = -0.34 Pearson correlation; P = .001) and lentiform nucleus (r = -0.67; P = .001) and a positive correlation in the occipital (r = 0.41; P = .001) and subcortical (r = 0.45; P = .001) WM. An age dependency for T2' values was only found for the caudate (r = -0.35; P = .001) and lentiform nucleus (r = -0.69; P = .001). T2' values in acute stroke were lower than normal in all patients with stroke.CONCLUSION: Decrease in T2' and T2* values in GM and increase of T2* values in WM correlate with the progress of brain aging. Explanations for decreasing T2' and T2* values include iron deposition in the caudate and lentiform nucleus. In contrast to T2* values, there is no association of T2' values with the degree of leukoaraiosis. These age-dependent values can be used as a reference in neurovascular diseases and for the discussion of functional MR imaging data.

AB - BACKGROUND AND PURPOSE: Physiologic age-related T2* and T2' values are required as reference for comparison with disease-related deviations. In our study, T2* and T2' values (T2 values as control) were determined with MR imaging in healthy subjects to determine standard values and investigate age-related changes.MATERIALS AND METHODS: Data of 50 patients without intraparenchymal pathology and 10 acute stroke patients who underwent MR imaging including a T2 and T2* sequence with 3 echotimes were included. After calculation of T2*, T2', and T2 maps, the values of gray matter (GM) and white matter (WM) for each hemisphere were measured in 6 distinct regions of interest (ROIs).RESULTS: There was a negative correlation between age and T2* values in the caudate nucleus (r = -0.34 Pearson correlation; P = .001) and lentiform nucleus (r = -0.67; P = .001) and a positive correlation in the occipital (r = 0.41; P = .001) and subcortical (r = 0.45; P = .001) WM. An age dependency for T2' values was only found for the caudate (r = -0.35; P = .001) and lentiform nucleus (r = -0.69; P = .001). T2' values in acute stroke were lower than normal in all patients with stroke.CONCLUSION: Decrease in T2' and T2* values in GM and increase of T2* values in WM correlate with the progress of brain aging. Explanations for decreasing T2' and T2* values include iron deposition in the caudate and lentiform nucleus. In contrast to T2* values, there is no association of T2' values with the degree of leukoaraiosis. These age-dependent values can be used as a reference in neurovascular diseases and for the discussion of functional MR imaging data.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aging

KW - Brain

KW - Child

KW - Female

KW - Germany

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Reference Values

U2 - 10.3174/ajnr.A0951

DO - 10.3174/ajnr.A0951

M3 - SCORING: Journal article

C2 - 18272561

VL - 29

SP - 950

EP - 955

JO - AM J NEURORADIOL

JF - AM J NEURORADIOL

SN - 0195-6108

IS - 5

ER -