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Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract

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Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract. / Porat, Shai; Sibilia, Francesca; Yoon, Josephine; Shi, Yonggang; Dahl, Martin J; Werkle-Bergner, Markus; Düzel, Sandra; Bodammer, Nils; Lindenberger, Ulman; Kühn, Simone; Mather, Mara.

In: NEUROIMAGE, Vol. 251, 119022, 01.05.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Porat, S, Sibilia, F, Yoon, J, Shi, Y, Dahl, MJ, Werkle-Bergner, M, Düzel, S, Bodammer, N, Lindenberger, U, Kühn, S & Mather, M 2022, 'Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract', NEUROIMAGE, vol. 251, 119022. https://doi.org/10.1016/j.neuroimage.2022.119022

APA

Porat, S., Sibilia, F., Yoon, J., Shi, Y., Dahl, M. J., Werkle-Bergner, M., Düzel, S., Bodammer, N., Lindenberger, U., Kühn, S., & Mather, M. (2022). Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract. NEUROIMAGE, 251, [119022]. https://doi.org/10.1016/j.neuroimage.2022.119022

Vancouver

Porat S, Sibilia F, Yoon J, Shi Y, Dahl MJ, Werkle-Bergner M et al. Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract. NEUROIMAGE. 2022 May 1;251. 119022. https://doi.org/10.1016/j.neuroimage.2022.119022

Bibtex

@article{a3293b616dd84829809adf995f4160e7,
title = "Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract",
abstract = "The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used two datasets (Berlin Aging Study-II, N = 301, the Leipzig Study for Mind-Body-Emotion Interactions, N = 220), to replicate published findings and expand them by investigating diffusivity in the LC's ascending noradrenergic bundle. In younger adults, LC fractional anisotropy was significantly lower, compared to older adults. However, in the LC's ascending noradrenergic bundle, we observed significantly higher fractional anisotropy in younger adults, relative to older adults. These findings indicate that diffusivity in the LC versus the ascending noradrenergic bundle are both susceptible to structural changes in aging that have opposing effects on fractional anisotropy.",
keywords = "Aged, Aging, Anisotropy, Diffusion Magnetic Resonance Imaging, Humans, Locus Coeruleus/diagnostic imaging, White Matter/diagnostic imaging",
author = "Shai Porat and Francesca Sibilia and Josephine Yoon and Yonggang Shi and Dahl, {Martin J} and Markus Werkle-Bergner and Sandra D{\"u}zel and Nils Bodammer and Ulman Lindenberger and Simone K{\"u}hn and Mara Mather",
note = "Published by Elsevier Inc.",
year = "2022",
month = may,
day = "1",
doi = "10.1016/j.neuroimage.2022.119022",
language = "English",
volume = "251",
journal = "NEUROIMAGE",
issn = "1053-8119",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract

AU - Porat, Shai

AU - Sibilia, Francesca

AU - Yoon, Josephine

AU - Shi, Yonggang

AU - Dahl, Martin J

AU - Werkle-Bergner, Markus

AU - Düzel, Sandra

AU - Bodammer, Nils

AU - Lindenberger, Ulman

AU - Kühn, Simone

AU - Mather, Mara

N1 - Published by Elsevier Inc.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used two datasets (Berlin Aging Study-II, N = 301, the Leipzig Study for Mind-Body-Emotion Interactions, N = 220), to replicate published findings and expand them by investigating diffusivity in the LC's ascending noradrenergic bundle. In younger adults, LC fractional anisotropy was significantly lower, compared to older adults. However, in the LC's ascending noradrenergic bundle, we observed significantly higher fractional anisotropy in younger adults, relative to older adults. These findings indicate that diffusivity in the LC versus the ascending noradrenergic bundle are both susceptible to structural changes in aging that have opposing effects on fractional anisotropy.

AB - The noradrenergic locus coeruleus (LC) is a small brainstem nucleus that promotes arousal and attention. Recent studies have examined the microstructural properties of the LC using diffusion-weighted magnetic resonance imaging and found unexpected age-related differences in fractional anisotropy - a measure of white matter integrity. Here, we used two datasets (Berlin Aging Study-II, N = 301, the Leipzig Study for Mind-Body-Emotion Interactions, N = 220), to replicate published findings and expand them by investigating diffusivity in the LC's ascending noradrenergic bundle. In younger adults, LC fractional anisotropy was significantly lower, compared to older adults. However, in the LC's ascending noradrenergic bundle, we observed significantly higher fractional anisotropy in younger adults, relative to older adults. These findings indicate that diffusivity in the LC versus the ascending noradrenergic bundle are both susceptible to structural changes in aging that have opposing effects on fractional anisotropy.

KW - Aged

KW - Aging

KW - Anisotropy

KW - Diffusion Magnetic Resonance Imaging

KW - Humans

KW - Locus Coeruleus/diagnostic imaging

KW - White Matter/diagnostic imaging

U2 - 10.1016/j.neuroimage.2022.119022

DO - 10.1016/j.neuroimage.2022.119022

M3 - SCORING: Journal article

C2 - 35192943

VL - 251

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

M1 - 119022

ER -