After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.

Johannes Schetelig; Astrid Breitschaft; Nicolaus Kröger; Tatjana Zabelina; Wolfram Ebell; Martin Bornhäuser; Astrid Haack; Gerhard Ehninger; Abdulgabar Salama; Wolfgang Siegert

After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.

Standard

After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B. / Schetelig, Johannes; Breitschaft, Astrid; Kröger, Nicolaus; Zabelina, Tatjana; Ebell, Wolfram; Bornhäuser, Martin; Haack, Astrid; Ehninger, Gerhard; Salama, Abdulgabar; Siegert, Wolfgang.

In: TRANSFUSION, Vol. 45, No. 5, 5, 2005, p. 779-787.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schetelig, J, Breitschaft, A, Kröger, N, Zabelina, T, Ebell, W, Bornhäuser, M, Haack, A, Ehninger, G, Salama, A & Siegert, W 2005, 'After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.', TRANSFUSION, vol. 45, no. 5, 5, pp. 779-787. <http://www.ncbi.nlm.nih.gov/pubmed/15847669?dopt=Citation>

APA

Schetelig, J., Breitschaft, A., Kröger, N., Zabelina, T., Ebell, W., Bornhäuser, M., Haack, A., Ehninger, G., Salama, A., & Siegert, W. (2005). After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B. TRANSFUSION, 45(5), 779-787. [5]. http://www.ncbi.nlm.nih.gov/pubmed/15847669?dopt=Citation

Vancouver

Schetelig J, Breitschaft A, Kröger N, Zabelina T, Ebell W, Bornhäuser M et al. After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B. TRANSFUSION. 2005;45(5):779-787. 5.

Bibtex

@article{aec352664b2545e0b9a4515feff1fba5,

title = "After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.",

abstract = "BACKGROUND: Isohemagglutinins directed against the donor blood group frequently delay erythroid engraftment after major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation (HPCT). Graft-versus-host reactions are capable of accelerating the clearance of isohemagglutinins. Whether immunogenicity of the A- and B-antigen is important in this process is unknown. PATIENTS AND METHODS: Data of 807 patients from three centers were screened for patients with major or bidirectionally ABO-mismatched donors. Clinical data and red blood cell (RBC) transfusion support were analyzed retrospectively. RESULTS: A total of 158 patients with major or bidirectionally mismatched donors were identified. After major mismatched HPCT, patients with anti-A directed against the donor blood group required RBC transfusion support for a median of 109 days (range, 0-324 days) compared to 21 days (range, 2-98 days) for patients with anti-B directed against donor blood group (log-rank test, p = 0.0001). Other risk factors associated with prolonged RBC transfusion support in univariate analysis were age (p = 0.024), cytomegalovirus infection (p = 0.016), hemolytic anemia (p = 0.027), and chronic bleeding disorders (p = 0.038). The independent influence of donor blood group and recipient age were confirmed in a multivariate analysis. CONCLUSION: These results indicate that the immunogenicity of the ABO antigen plays an important role for the kinetics of erythroid engraftment after ABO-mismatched HPCT.",

author = "Johannes Schetelig and Astrid Breitschaft and Nicolaus Kr{\"o}ger and Tatjana Zabelina and Wolfram Ebell and Martin Bornh{\"a}user and Astrid Haack and Gerhard Ehninger and Abdulgabar Salama and Wolfgang Siegert",

year = "2005",

language = "Deutsch",

volume = "45",

pages = "779--787",

journal = "TRANSFUSION",

issn = "0041-1132",

publisher = "Wiley-Blackwell",

number = "5",

}

RIS

TY - JOUR

T1 - After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.

AU - Schetelig, Johannes

AU - Breitschaft, Astrid

AU - Kröger, Nicolaus

AU - Zabelina, Tatjana

AU - Ebell, Wolfram

AU - Bornhäuser, Martin

AU - Haack, Astrid

AU - Ehninger, Gerhard

AU - Salama, Abdulgabar

AU - Siegert, Wolfgang

PY - 2005

Y1 - 2005

N2 - BACKGROUND: Isohemagglutinins directed against the donor blood group frequently delay erythroid engraftment after major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation (HPCT). Graft-versus-host reactions are capable of accelerating the clearance of isohemagglutinins. Whether immunogenicity of the A- and B-antigen is important in this process is unknown. PATIENTS AND METHODS: Data of 807 patients from three centers were screened for patients with major or bidirectionally ABO-mismatched donors. Clinical data and red blood cell (RBC) transfusion support were analyzed retrospectively. RESULTS: A total of 158 patients with major or bidirectionally mismatched donors were identified. After major mismatched HPCT, patients with anti-A directed against the donor blood group required RBC transfusion support for a median of 109 days (range, 0-324 days) compared to 21 days (range, 2-98 days) for patients with anti-B directed against donor blood group (log-rank test, p = 0.0001). Other risk factors associated with prolonged RBC transfusion support in univariate analysis were age (p = 0.024), cytomegalovirus infection (p = 0.016), hemolytic anemia (p = 0.027), and chronic bleeding disorders (p = 0.038). The independent influence of donor blood group and recipient age were confirmed in a multivariate analysis. CONCLUSION: These results indicate that the immunogenicity of the ABO antigen plays an important role for the kinetics of erythroid engraftment after ABO-mismatched HPCT.

AB - BACKGROUND: Isohemagglutinins directed against the donor blood group frequently delay erythroid engraftment after major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation (HPCT). Graft-versus-host reactions are capable of accelerating the clearance of isohemagglutinins. Whether immunogenicity of the A- and B-antigen is important in this process is unknown. PATIENTS AND METHODS: Data of 807 patients from three centers were screened for patients with major or bidirectionally ABO-mismatched donors. Clinical data and red blood cell (RBC) transfusion support were analyzed retrospectively. RESULTS: A total of 158 patients with major or bidirectionally mismatched donors were identified. After major mismatched HPCT, patients with anti-A directed against the donor blood group required RBC transfusion support for a median of 109 days (range, 0-324 days) compared to 21 days (range, 2-98 days) for patients with anti-B directed against donor blood group (log-rank test, p = 0.0001). Other risk factors associated with prolonged RBC transfusion support in univariate analysis were age (p = 0.024), cytomegalovirus infection (p = 0.016), hemolytic anemia (p = 0.027), and chronic bleeding disorders (p = 0.038). The independent influence of donor blood group and recipient age were confirmed in a multivariate analysis. CONCLUSION: These results indicate that the immunogenicity of the ABO antigen plays an important role for the kinetics of erythroid engraftment after ABO-mismatched HPCT.

M3 - SCORING: Zeitschriftenaufsatz

VL - 45

SP - 779

EP - 787

JO - TRANSFUSION

JF - TRANSFUSION

SN - 0041-1132

IS - 5

M1 - 5

ER -