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African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients

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African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients. / Panunzio, Andrea; Tappero, Stefano; Hohenhorst, Lukas; Cano Garcia, Cristina; Piccinelli, Mattia; Barletta, Francesco; Tian, Zhe; Tafuri, Alessandro; Briganti, Alberto; De Cobelli, Ottavio; Chun, Felix K H; Tilki, Derya; Terrone, Carlo; Saad, Fred; Shariat, Shahrokh F; Bourdeau, Isabelle; Cerruto, Maria Angela; Antonelli, Alessandro; Karakiewicz, Pierre I.

In: ENDOCR-RELAT CANCER, Vol. 30, No. 7, e220249, 01.07.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Panunzio, A, Tappero, S, Hohenhorst, L, Cano Garcia, C, Piccinelli, M, Barletta, F, Tian, Z, Tafuri, A, Briganti, A, De Cobelli, O, Chun, FKH, Tilki, D, Terrone, C, Saad, F, Shariat, SF, Bourdeau, I, Cerruto, MA, Antonelli, A & Karakiewicz, PI 2023, 'African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients', ENDOCR-RELAT CANCER, vol. 30, no. 7, e220249. https://doi.org/10.1530/ERC-22-0249

APA

Panunzio, A., Tappero, S., Hohenhorst, L., Cano Garcia, C., Piccinelli, M., Barletta, F., Tian, Z., Tafuri, A., Briganti, A., De Cobelli, O., Chun, F. K. H., Tilki, D., Terrone, C., Saad, F., Shariat, S. F., Bourdeau, I., Cerruto, M. A., Antonelli, A., & Karakiewicz, P. I. (2023). African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients. ENDOCR-RELAT CANCER, 30(7), [e220249]. https://doi.org/10.1530/ERC-22-0249

Vancouver

Panunzio A, Tappero S, Hohenhorst L, Cano Garcia C, Piccinelli M, Barletta F et al. African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients. ENDOCR-RELAT CANCER. 2023 Jul 1;30(7). e220249. https://doi.org/10.1530/ERC-22-0249

Bibtex

@article{8b418add960e43a78ab94022d470eb20,
title = "African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients",
abstract = "In some primaries, African American race/ethnicity predisposes to higher stage and worse survival. We tested for differences in cancer-specific mortality (CSM) and other-cause mortality (OCM) in patients with adrenocortical carcinoma (ACC) according to African American vs Caucasian race/ethnicity. We hypothesized that African Americans present with higher tumor stage and grade, do not receive the same treatment, and experience worse oncological outcomes than Caucasians. Within Surveillance, Epidemiology, and End Results database, we identified 1016 ACC patients: 123 (12.1%) African Americans vs 893 (87.9%) Caucasians. Propensity score matching (PSM) (age, sex, marital status, grade, T, N, and M stages, and treatment type), Poisson-smoothed cumulative incidence plots, and competing risk regression (CRR) were used. Compared to Caucasians, African Americans were more frequently unmarried (56.9% vs 35.5%, P < 0.001). No clinically meaningful or statistically significant differences were observed for age, grade, T, N, and M stages, as well as treatment type (all P > 0.05). After PSM (1:4), 123 African Americans and 492 Caucasians remained and were included in CRR analysis. In multivariable CRR models, CSM and OCM rates were not different between the two race/ethnicities (hazard ratio: 0.84, P = 0.3). In African Americans, 5-year CSM rates were 31.2% and 75.3% in European Network for the Study of Adrenal Tumors (ENSAT) stages I-II and III-IV, respectively vs 32.9% and 75.4% in Caucasians. Overall 5-year OCM rates were 11.0% vs 10.1% in respectively African Americans and Caucasians. Unlike other primaries, in ACC, African American race/ethnicity is not associated with higher disease stage at initial diagnosis or worse survival.",
keywords = "Humans, Adrenal Cortex Neoplasms/ethnology, Adrenocortical Carcinoma/ethnology, Black or African American, Ethnicity, White",
author = "Andrea Panunzio and Stefano Tappero and Lukas Hohenhorst and {Cano Garcia}, Cristina and Mattia Piccinelli and Francesco Barletta and Zhe Tian and Alessandro Tafuri and Alberto Briganti and {De Cobelli}, Ottavio and Chun, {Felix K H} and Derya Tilki and Carlo Terrone and Fred Saad and Shariat, {Shahrokh F} and Isabelle Bourdeau and Cerruto, {Maria Angela} and Alessandro Antonelli and Karakiewicz, {Pierre I}",
year = "2023",
month = jul,
day = "1",
doi = "10.1530/ERC-22-0249",
language = "English",
volume = "30",
journal = "ENDOCR-RELAT CANCER",
issn = "1351-0088",
publisher = "Society for Endocrinology",
number = "7",

}

RIS

TY - JOUR

T1 - African American vs Caucasian race/ethnicity in adrenocortical carcinoma patients

AU - Panunzio, Andrea

AU - Tappero, Stefano

AU - Hohenhorst, Lukas

AU - Cano Garcia, Cristina

AU - Piccinelli, Mattia

AU - Barletta, Francesco

AU - Tian, Zhe

AU - Tafuri, Alessandro

AU - Briganti, Alberto

AU - De Cobelli, Ottavio

AU - Chun, Felix K H

AU - Tilki, Derya

AU - Terrone, Carlo

AU - Saad, Fred

AU - Shariat, Shahrokh F

AU - Bourdeau, Isabelle

AU - Cerruto, Maria Angela

AU - Antonelli, Alessandro

AU - Karakiewicz, Pierre I

PY - 2023/7/1

Y1 - 2023/7/1

N2 - In some primaries, African American race/ethnicity predisposes to higher stage and worse survival. We tested for differences in cancer-specific mortality (CSM) and other-cause mortality (OCM) in patients with adrenocortical carcinoma (ACC) according to African American vs Caucasian race/ethnicity. We hypothesized that African Americans present with higher tumor stage and grade, do not receive the same treatment, and experience worse oncological outcomes than Caucasians. Within Surveillance, Epidemiology, and End Results database, we identified 1016 ACC patients: 123 (12.1%) African Americans vs 893 (87.9%) Caucasians. Propensity score matching (PSM) (age, sex, marital status, grade, T, N, and M stages, and treatment type), Poisson-smoothed cumulative incidence plots, and competing risk regression (CRR) were used. Compared to Caucasians, African Americans were more frequently unmarried (56.9% vs 35.5%, P < 0.001). No clinically meaningful or statistically significant differences were observed for age, grade, T, N, and M stages, as well as treatment type (all P > 0.05). After PSM (1:4), 123 African Americans and 492 Caucasians remained and were included in CRR analysis. In multivariable CRR models, CSM and OCM rates were not different between the two race/ethnicities (hazard ratio: 0.84, P = 0.3). In African Americans, 5-year CSM rates were 31.2% and 75.3% in European Network for the Study of Adrenal Tumors (ENSAT) stages I-II and III-IV, respectively vs 32.9% and 75.4% in Caucasians. Overall 5-year OCM rates were 11.0% vs 10.1% in respectively African Americans and Caucasians. Unlike other primaries, in ACC, African American race/ethnicity is not associated with higher disease stage at initial diagnosis or worse survival.

AB - In some primaries, African American race/ethnicity predisposes to higher stage and worse survival. We tested for differences in cancer-specific mortality (CSM) and other-cause mortality (OCM) in patients with adrenocortical carcinoma (ACC) according to African American vs Caucasian race/ethnicity. We hypothesized that African Americans present with higher tumor stage and grade, do not receive the same treatment, and experience worse oncological outcomes than Caucasians. Within Surveillance, Epidemiology, and End Results database, we identified 1016 ACC patients: 123 (12.1%) African Americans vs 893 (87.9%) Caucasians. Propensity score matching (PSM) (age, sex, marital status, grade, T, N, and M stages, and treatment type), Poisson-smoothed cumulative incidence plots, and competing risk regression (CRR) were used. Compared to Caucasians, African Americans were more frequently unmarried (56.9% vs 35.5%, P < 0.001). No clinically meaningful or statistically significant differences were observed for age, grade, T, N, and M stages, as well as treatment type (all P > 0.05). After PSM (1:4), 123 African Americans and 492 Caucasians remained and were included in CRR analysis. In multivariable CRR models, CSM and OCM rates were not different between the two race/ethnicities (hazard ratio: 0.84, P = 0.3). In African Americans, 5-year CSM rates were 31.2% and 75.3% in European Network for the Study of Adrenal Tumors (ENSAT) stages I-II and III-IV, respectively vs 32.9% and 75.4% in Caucasians. Overall 5-year OCM rates were 11.0% vs 10.1% in respectively African Americans and Caucasians. Unlike other primaries, in ACC, African American race/ethnicity is not associated with higher disease stage at initial diagnosis or worse survival.

KW - Humans

KW - Adrenal Cortex Neoplasms/ethnology

KW - Adrenocortical Carcinoma/ethnology

KW - Black or African American

KW - Ethnicity

KW - White

U2 - 10.1530/ERC-22-0249

DO - 10.1530/ERC-22-0249

M3 - SCORING: Journal article

C2 - 37043366

VL - 30

JO - ENDOCR-RELAT CANCER

JF - ENDOCR-RELAT CANCER

SN - 1351-0088

IS - 7

M1 - e220249

ER -