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Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study

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Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study. / Kohns Vasconcelos, Malte; Loens, Katherine; Sigfrid, Louise; Iosifidis, Elias; Epalza, Cristina; Donà, Daniele; Matheeussen, Veerle; Papachristou, Savvas; Roilides, Emmanuel; Gijon, Manuel; Rojo, Pablo; Minotti, Chiara; Da Dalt, Liviana; Islam, Samsul; Jarvis, Jessica; Syggelou, Aggeliki; Tsolia, Maria; Nyirenda Nyang'wa, Maggie; Keers, Sophie; Renk, Hanna; Gemmel, Anna-Lena; D'Amore, Carmen; Ciofi Degli Atti, Marta; Rodríguez-Tenreiro Sánchez, Carmen; Martinón-Torres, Federico; Burokienė, Sigita; Goetghebuer, Tessa; Spoulou, Vana; Riordan, Andrew; Calvo, Cristina; Gkentzi, Despoina; Hufnagel, Markus; Openshaw, Peter J; de Jong, Menno D; Koopmans, Marion; Goossens, Herman; Ieven, Margareta; Fraaij, Pieter L A; Giaquinto, Carlo; Bielicki, Julia A; Horby, Peter; Sharland, Michael.

In: BMJ Open Respiratory Research, Vol. 8, No. 1, e000887, 07.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kohns Vasconcelos, M, Loens, K, Sigfrid, L, Iosifidis, E, Epalza, C, Donà, D, Matheeussen, V, Papachristou, S, Roilides, E, Gijon, M, Rojo, P, Minotti, C, Da Dalt, L, Islam, S, Jarvis, J, Syggelou, A, Tsolia, M, Nyirenda Nyang'wa, M, Keers, S, Renk, H, Gemmel, A-L, D'Amore, C, Ciofi Degli Atti, M, Rodríguez-Tenreiro Sánchez, C, Martinón-Torres, F, Burokienė, S, Goetghebuer, T, Spoulou, V, Riordan, A, Calvo, C, Gkentzi, D, Hufnagel, M, Openshaw, PJ, de Jong, MD, Koopmans, M, Goossens, H, Ieven, M, Fraaij, PLA, Giaquinto, C, Bielicki, JA, Horby, P & Sharland, M 2021, 'Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study', BMJ Open Respiratory Research, vol. 8, no. 1, e000887. https://doi.org/10.1136/bmjresp-2021-000887

APA

Kohns Vasconcelos, M., Loens, K., Sigfrid, L., Iosifidis, E., Epalza, C., Donà, D., Matheeussen, V., Papachristou, S., Roilides, E., Gijon, M., Rojo, P., Minotti, C., Da Dalt, L., Islam, S., Jarvis, J., Syggelou, A., Tsolia, M., Nyirenda Nyang'wa, M., Keers, S., ... Sharland, M. (2021). Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study. BMJ Open Respiratory Research, 8(1), [e000887]. https://doi.org/10.1136/bmjresp-2021-000887

Vancouver

Kohns Vasconcelos M, Loens K, Sigfrid L, Iosifidis E, Epalza C, Donà D et al. Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study. BMJ Open Respiratory Research. 2021 Jul;8(1). e000887. https://doi.org/10.1136/bmjresp-2021-000887

Bibtex

@article{3c702262d89a4e8cb782abaa2dfc1c04,
title = "Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study",
abstract = "BACKGROUND: Both pathogenic bacteria and viruses are frequently detected in the nasopharynx (NP) of children in the absence of acute respiratory infection (ARI) symptoms. The aim of this study was to estimate the aetiological fractions for ARI hospitalisation in children for respiratory syncytial virus (RSV) and influenza virus and to determine whether detection of specific respiratory pathogens on NP samples was associated with ARI hospitalisation.METHODS: 349 children up to 5 years of age hospitalised for ARI (following a symptom-based case definition) and 306 hospital controls were prospectively enrolled in 16 centres across seven European Union countries between 2016 and 2019. Admission day NP swabs were analysed by multiplex PCR for 25 targets.RESULTS: RSV was the leading single cause of ARI hospitalisations, with an overall population attributable fraction (PAF) of 33.4% and high seasonality as well as preponderance in younger children. Detection of RSV on NP swabs was strongly associated with ARI hospitalisation (OR adjusted for age and season: 20.6, 95% CI: 9.4 to 45.3). Detection of three other viral pathogens showed strong associations with ARI hospitalisation: influenza viruses had an adjusted OR of 6.1 (95% CI: 2.5 to 14.9), parainfluenza viruses (PIVs) an adjusted OR of 4.6 (95% CI: 1.8 to 11.3) and metapneumoviruses an adjusted OR of 4.5 (95% CI: 1.3 to 16.1). Influenza viruses had a PAF of 7.9%, PIVs of 6.5% and metapneumoviruses of 3.0%. In contrast, most other pathogens were found in similar proportions in cases and controls, including Streptococcus pneumoniae, which was weakly associated with case status, and endemic coronaviruses.CONCLUSION: RSV is the predominant cause of ARI hospitalisations in young children in Europe and its detection, as well as detection of influenza virus, PIV or metapneumovirus, on NP swabs can establish aetiology with high probability. PAFs for RSV and influenza virus are highly seasonal and age dependent.",
keywords = "Case-Control Studies, Child, Preschool, Hospitalization, Humans, Respiratory Syncytial Virus Infections/diagnosis, Respiratory Syncytial Virus, Human, Respiratory Tract Infections/epidemiology",
author = "{Kohns Vasconcelos}, Malte and Katherine Loens and Louise Sigfrid and Elias Iosifidis and Cristina Epalza and Daniele Don{\`a} and Veerle Matheeussen and Savvas Papachristou and Emmanuel Roilides and Manuel Gijon and Pablo Rojo and Chiara Minotti and {Da Dalt}, Liviana and Samsul Islam and Jessica Jarvis and Aggeliki Syggelou and Maria Tsolia and {Nyirenda Nyang'wa}, Maggie and Sophie Keers and Hanna Renk and Anna-Lena Gemmel and Carmen D'Amore and {Ciofi Degli Atti}, Marta and {Rodr{\'i}guez-Tenreiro S{\'a}nchez}, Carmen and Federico Martin{\'o}n-Torres and Sigita Burokienė and Tessa Goetghebuer and Vana Spoulou and Andrew Riordan and Cristina Calvo and Despoina Gkentzi and Markus Hufnagel and Openshaw, {Peter J} and {de Jong}, {Menno D} and Marion Koopmans and Herman Goossens and Margareta Ieven and Fraaij, {Pieter L A} and Carlo Giaquinto and Bielicki, {Julia A} and Peter Horby and Michael Sharland",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = jul,
doi = "10.1136/bmjresp-2021-000887",
language = "English",
volume = "8",
journal = "BMJ Open Respir Res",
issn = "2052-4439",
publisher = "BMJ PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study

AU - Kohns Vasconcelos, Malte

AU - Loens, Katherine

AU - Sigfrid, Louise

AU - Iosifidis, Elias

AU - Epalza, Cristina

AU - Donà, Daniele

AU - Matheeussen, Veerle

AU - Papachristou, Savvas

AU - Roilides, Emmanuel

AU - Gijon, Manuel

AU - Rojo, Pablo

AU - Minotti, Chiara

AU - Da Dalt, Liviana

AU - Islam, Samsul

AU - Jarvis, Jessica

AU - Syggelou, Aggeliki

AU - Tsolia, Maria

AU - Nyirenda Nyang'wa, Maggie

AU - Keers, Sophie

AU - Renk, Hanna

AU - Gemmel, Anna-Lena

AU - D'Amore, Carmen

AU - Ciofi Degli Atti, Marta

AU - Rodríguez-Tenreiro Sánchez, Carmen

AU - Martinón-Torres, Federico

AU - Burokienė, Sigita

AU - Goetghebuer, Tessa

AU - Spoulou, Vana

AU - Riordan, Andrew

AU - Calvo, Cristina

AU - Gkentzi, Despoina

AU - Hufnagel, Markus

AU - Openshaw, Peter J

AU - de Jong, Menno D

AU - Koopmans, Marion

AU - Goossens, Herman

AU - Ieven, Margareta

AU - Fraaij, Pieter L A

AU - Giaquinto, Carlo

AU - Bielicki, Julia A

AU - Horby, Peter

AU - Sharland, Michael

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/7

Y1 - 2021/7

N2 - BACKGROUND: Both pathogenic bacteria and viruses are frequently detected in the nasopharynx (NP) of children in the absence of acute respiratory infection (ARI) symptoms. The aim of this study was to estimate the aetiological fractions for ARI hospitalisation in children for respiratory syncytial virus (RSV) and influenza virus and to determine whether detection of specific respiratory pathogens on NP samples was associated with ARI hospitalisation.METHODS: 349 children up to 5 years of age hospitalised for ARI (following a symptom-based case definition) and 306 hospital controls were prospectively enrolled in 16 centres across seven European Union countries between 2016 and 2019. Admission day NP swabs were analysed by multiplex PCR for 25 targets.RESULTS: RSV was the leading single cause of ARI hospitalisations, with an overall population attributable fraction (PAF) of 33.4% and high seasonality as well as preponderance in younger children. Detection of RSV on NP swabs was strongly associated with ARI hospitalisation (OR adjusted for age and season: 20.6, 95% CI: 9.4 to 45.3). Detection of three other viral pathogens showed strong associations with ARI hospitalisation: influenza viruses had an adjusted OR of 6.1 (95% CI: 2.5 to 14.9), parainfluenza viruses (PIVs) an adjusted OR of 4.6 (95% CI: 1.8 to 11.3) and metapneumoviruses an adjusted OR of 4.5 (95% CI: 1.3 to 16.1). Influenza viruses had a PAF of 7.9%, PIVs of 6.5% and metapneumoviruses of 3.0%. In contrast, most other pathogens were found in similar proportions in cases and controls, including Streptococcus pneumoniae, which was weakly associated with case status, and endemic coronaviruses.CONCLUSION: RSV is the predominant cause of ARI hospitalisations in young children in Europe and its detection, as well as detection of influenza virus, PIV or metapneumovirus, on NP swabs can establish aetiology with high probability. PAFs for RSV and influenza virus are highly seasonal and age dependent.

AB - BACKGROUND: Both pathogenic bacteria and viruses are frequently detected in the nasopharynx (NP) of children in the absence of acute respiratory infection (ARI) symptoms. The aim of this study was to estimate the aetiological fractions for ARI hospitalisation in children for respiratory syncytial virus (RSV) and influenza virus and to determine whether detection of specific respiratory pathogens on NP samples was associated with ARI hospitalisation.METHODS: 349 children up to 5 years of age hospitalised for ARI (following a symptom-based case definition) and 306 hospital controls were prospectively enrolled in 16 centres across seven European Union countries between 2016 and 2019. Admission day NP swabs were analysed by multiplex PCR for 25 targets.RESULTS: RSV was the leading single cause of ARI hospitalisations, with an overall population attributable fraction (PAF) of 33.4% and high seasonality as well as preponderance in younger children. Detection of RSV on NP swabs was strongly associated with ARI hospitalisation (OR adjusted for age and season: 20.6, 95% CI: 9.4 to 45.3). Detection of three other viral pathogens showed strong associations with ARI hospitalisation: influenza viruses had an adjusted OR of 6.1 (95% CI: 2.5 to 14.9), parainfluenza viruses (PIVs) an adjusted OR of 4.6 (95% CI: 1.8 to 11.3) and metapneumoviruses an adjusted OR of 4.5 (95% CI: 1.3 to 16.1). Influenza viruses had a PAF of 7.9%, PIVs of 6.5% and metapneumoviruses of 3.0%. In contrast, most other pathogens were found in similar proportions in cases and controls, including Streptococcus pneumoniae, which was weakly associated with case status, and endemic coronaviruses.CONCLUSION: RSV is the predominant cause of ARI hospitalisations in young children in Europe and its detection, as well as detection of influenza virus, PIV or metapneumovirus, on NP swabs can establish aetiology with high probability. PAFs for RSV and influenza virus are highly seasonal and age dependent.

KW - Case-Control Studies

KW - Child, Preschool

KW - Hospitalization

KW - Humans

KW - Respiratory Syncytial Virus Infections/diagnosis

KW - Respiratory Syncytial Virus, Human

KW - Respiratory Tract Infections/epidemiology

U2 - 10.1136/bmjresp-2021-000887

DO - 10.1136/bmjresp-2021-000887

M3 - SCORING: Journal article

C2 - 34326154

VL - 8

JO - BMJ Open Respir Res

JF - BMJ Open Respir Res

SN - 2052-4439

IS - 1

M1 - e000887

ER -