Research ExplorerPublicationsAdverse Outcome Prediction of Iron Deficiency in Patients wi...

Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome

Standard

Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome. / Zeller, Tanja; Waldeyer, Christoph; Ojeda, Francisco; Schnabel, Renate B; Schäfer, Sarina; Altay, Alev; Lackner, Karl J; Anker, Stefan D; Westermann, Dirk; Blankenberg, Stefan; Karakas, Mahir.

In: BIOMOLECULES, Vol. 8, No. 3, 60, 20.07.2018.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zeller, T, Waldeyer, C, Ojeda, F, Schnabel, RB, Schäfer, S, Altay, A, Lackner, KJ, Anker, SD, Westermann, D, Blankenberg, S & Karakas, M 2018, 'Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome', BIOMOLECULES, vol. 8, no. 3, 60. https://doi.org/10.3390/biom8030060

APA

Zeller, T., Waldeyer, C., Ojeda, F., Schnabel, R. B., Schäfer, S., Altay, A., Lackner, K. J., Anker, S. D., Westermann, D., Blankenberg, S., & Karakas, M. (2018). Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome. BIOMOLECULES, 8(3), [60]. https://doi.org/10.3390/biom8030060

Vancouver

Zeller T, Waldeyer C, Ojeda F, Schnabel RB, Schäfer S, Altay A et al. Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome. BIOMOLECULES. 2018 Jul 20;8(3). 60. https://doi.org/10.3390/biom8030060

Bibtex

@article{fdec96ddf377457db869805d885ac30d,
title = "Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome",
abstract = "Acute myocardial infarction remains a leading cause of morbidity and mortality. While iron deficient heart failure patients are at increased risk of future cardiovascular events and see improvement with intravenous supplementation, the clinical relevance of iron deficiency in acute coronary syndrome remains unclear. We aimed to evaluate the prognostic value of iron deficiency in the acute coronary syndrome (ACS). Levels of ferritin, iron, and transferrin were measured at baseline in 836 patients with ACS. A total of 29.1% was categorized as iron deficient. The prevalence of iron deficiency was clearly higher in women (42.8%), and in patients with anemia (42.5%). During a median follow-up of 4.0 years, 111 subjects (13.3%) experienced non-fatal myocardial infarction (MI) and cardiovascular mortality as combined endpoint. Iron deficiency strongly predicted non-fatal MI and cardiovascular mortality with a hazard ratio (HR) of 1.52 (95% confidence interval (CI) 1.03-2.26; p = 0.037) adjusted for age, sex, hypertension, smoking status, diabetes, hyperlipidemia, body-mass-index (BMI) This association remained significant (HR 1.73 (95% CI 1.07⁻2.81; p = 0.026)) after an additional adjustment for surrogates of cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide, NT-proBNP), for the size of myocardial necrosis (troponin), and for anemia (hemoglobin). Survival analyses for cardiovascular mortality and MI provided further evidence for the prognostic relevance of iron deficiency (HR 1.50 (95% CI 1.02⁻2.20)). Our data showed that iron deficiency is strongly associated with adverse outcome in acute coronary syndrome.",
keywords = "Acute Coronary Syndrome/complications, Aged, Anemia, Iron-Deficiency/epidemiology, Female, Humans, Male, Middle Aged, Myocardial Infarction/epidemiology, Natriuretic Peptide, Brain/metabolism, Peptide Fragments/metabolism, Prevalence, Prognosis, Troponin/metabolism",
author = "Tanja Zeller and Christoph Waldeyer and Francisco Ojeda and Schnabel, {Renate B} and Sarina Sch{\"a}fer and Alev Altay and Lackner, {Karl J} and Anker, {Stefan D} and Dirk Westermann and Stefan Blankenberg and Mahir Karakas",
year = "2018",
month = jul,
day = "20",
doi = "10.3390/biom8030060",
language = "English",
volume = "8",
journal = "BIOMOLECULES",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "3",

}

RIS

TY - JOUR

T1 - Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome

AU - Zeller, Tanja

AU - Waldeyer, Christoph

AU - Ojeda, Francisco

AU - Schnabel, Renate B

AU - Schäfer, Sarina

AU - Altay, Alev

AU - Lackner, Karl J

AU - Anker, Stefan D

AU - Westermann, Dirk

AU - Blankenberg, Stefan

AU - Karakas, Mahir

PY - 2018/7/20

Y1 - 2018/7/20

N2 - Acute myocardial infarction remains a leading cause of morbidity and mortality. While iron deficient heart failure patients are at increased risk of future cardiovascular events and see improvement with intravenous supplementation, the clinical relevance of iron deficiency in acute coronary syndrome remains unclear. We aimed to evaluate the prognostic value of iron deficiency in the acute coronary syndrome (ACS). Levels of ferritin, iron, and transferrin were measured at baseline in 836 patients with ACS. A total of 29.1% was categorized as iron deficient. The prevalence of iron deficiency was clearly higher in women (42.8%), and in patients with anemia (42.5%). During a median follow-up of 4.0 years, 111 subjects (13.3%) experienced non-fatal myocardial infarction (MI) and cardiovascular mortality as combined endpoint. Iron deficiency strongly predicted non-fatal MI and cardiovascular mortality with a hazard ratio (HR) of 1.52 (95% confidence interval (CI) 1.03-2.26; p = 0.037) adjusted for age, sex, hypertension, smoking status, diabetes, hyperlipidemia, body-mass-index (BMI) This association remained significant (HR 1.73 (95% CI 1.07⁻2.81; p = 0.026)) after an additional adjustment for surrogates of cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide, NT-proBNP), for the size of myocardial necrosis (troponin), and for anemia (hemoglobin). Survival analyses for cardiovascular mortality and MI provided further evidence for the prognostic relevance of iron deficiency (HR 1.50 (95% CI 1.02⁻2.20)). Our data showed that iron deficiency is strongly associated with adverse outcome in acute coronary syndrome.

AB - Acute myocardial infarction remains a leading cause of morbidity and mortality. While iron deficient heart failure patients are at increased risk of future cardiovascular events and see improvement with intravenous supplementation, the clinical relevance of iron deficiency in acute coronary syndrome remains unclear. We aimed to evaluate the prognostic value of iron deficiency in the acute coronary syndrome (ACS). Levels of ferritin, iron, and transferrin were measured at baseline in 836 patients with ACS. A total of 29.1% was categorized as iron deficient. The prevalence of iron deficiency was clearly higher in women (42.8%), and in patients with anemia (42.5%). During a median follow-up of 4.0 years, 111 subjects (13.3%) experienced non-fatal myocardial infarction (MI) and cardiovascular mortality as combined endpoint. Iron deficiency strongly predicted non-fatal MI and cardiovascular mortality with a hazard ratio (HR) of 1.52 (95% confidence interval (CI) 1.03-2.26; p = 0.037) adjusted for age, sex, hypertension, smoking status, diabetes, hyperlipidemia, body-mass-index (BMI) This association remained significant (HR 1.73 (95% CI 1.07⁻2.81; p = 0.026)) after an additional adjustment for surrogates of cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide, NT-proBNP), for the size of myocardial necrosis (troponin), and for anemia (hemoglobin). Survival analyses for cardiovascular mortality and MI provided further evidence for the prognostic relevance of iron deficiency (HR 1.50 (95% CI 1.02⁻2.20)). Our data showed that iron deficiency is strongly associated with adverse outcome in acute coronary syndrome.

KW - Acute Coronary Syndrome/complications

KW - Aged

KW - Anemia, Iron-Deficiency/epidemiology

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/epidemiology

KW - Natriuretic Peptide, Brain/metabolism

KW - Peptide Fragments/metabolism

KW - Prevalence

KW - Prognosis

KW - Troponin/metabolism

U2 - 10.3390/biom8030060

DO - 10.3390/biom8030060

M3 - SCORING: Journal article

C2 - 30037035

VL - 8

JO - BIOMOLECULES

JF - BIOMOLECULES

SN - 2218-273X

IS - 3

M1 - 60

ER -