Research ExplorerPublicationsAdvancing Age and the Odds of Upgrading and Upstaging at Rad...

Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer

Standard

Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer. / Leeman, Jonathan E; Chen, Ming-Hui; Huland, Hartwig; Graefen, Markus; D'Amico, Anthony V; Tilki, Derya.

In: CLIN GENITOURIN CANC, Vol. 17, No. 6, 12.2019, p. e1116-e1121.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Leeman, JE, Chen, M-H, Huland, H, Graefen, M, D'Amico, AV & Tilki, D 2019, 'Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer', CLIN GENITOURIN CANC, vol. 17, no. 6, pp. e1116-e1121. https://doi.org/10.1016/j.clgc.2019.07.018

APA

Leeman, J. E., Chen, M-H., Huland, H., Graefen, M., D'Amico, A. V., & Tilki, D. (2019). Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer. CLIN GENITOURIN CANC, 17(6), e1116-e1121. https://doi.org/10.1016/j.clgc.2019.07.018

Vancouver

Leeman JE, Chen M-H, Huland H, Graefen M, D'Amico AV, Tilki D. Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer. CLIN GENITOURIN CANC. 2019 Dec;17(6):e1116-e1121. https://doi.org/10.1016/j.clgc.2019.07.018

Bibtex

@article{8af584321552461198eaac6d0780b7e3,
title = "Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer",
abstract = "PURPOSE: To identify a subset of men with Gleason score (GS) 6 prostate cancer who are at high risk for upgrading/upstaging who should be recommended for multiparametric magnetic resonance imaging.PATIENTS AND METHODS: Between 1992 and 2017, a total of 3571 men with GS6 prostate cancer were consecutively treated at a single institution with radical prostatectomy. Logistic regression multivariable analyses to determine the odds of upgrading and upstaging were performed, adjusting for age and year of diagnosis, clinical T category, prostate-specific antigen level, number of biopsy cores, and percentage of positive biopsy cores.RESULTS: Of 3571 men, the disease of 115 (3.22%), 245 (6.86%), and 254 (7.11%) was upgraded, was upstaged, or had positive surgical margins (R1), respectively. Older age at diagnosis was associated with an increased risk of upgrading disease to GS7 or higher, prostatectomy T3/T4, and R1 with adjusted odds ratios (95% confidence intervals) of 1.05 (1.01-1.08; P = .005), 1.02 (1.00-1.05; P = .048), and 1.02 (1.002-1.05; P = .03), respectively. Older age was associated with an increasing proportion of men with disease upgraded to GS7 or higher (T1c: P = .002; T2 or higher: P = .04) or upstaged to pT3/4 or pT2R1 (T1c: P = .02; T2 or higher: P = .02) among men with ≥ 33% but not < 33% positive biopsy cores.CONCLUSION: Before initiating active surveillance, performing multiparametric magnetic resonance imaging in otherwise healthy older men with GS6 prostate cancer and ≥ 33% positive biopsy cores should be considered.",
keywords = "Age Factors, Aged, Biopsy, Large-Core Needle, Case-Control Studies, Humans, Logistic Models, Male, Margins of Excision, Middle Aged, Multiparametric Magnetic Resonance Imaging/methods, Neoplasm Grading, Neoplasm Staging, Prostate-Specific Antigen/blood, Prostatectomy/methods, Prostatic Neoplasms/blood",
author = "Leeman, {Jonathan E} and Ming-Hui Chen and Hartwig Huland and Markus Graefen and D'Amico, {Anthony V} and Derya Tilki",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = dec,
doi = "10.1016/j.clgc.2019.07.018",
language = "English",
volume = "17",
pages = "e1116--e1121",
journal = "CLIN GENITOURIN CANC",
issn = "1558-7673",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer

AU - Leeman, Jonathan E

AU - Chen, Ming-Hui

AU - Huland, Hartwig

AU - Graefen, Markus

AU - D'Amico, Anthony V

AU - Tilki, Derya

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - PURPOSE: To identify a subset of men with Gleason score (GS) 6 prostate cancer who are at high risk for upgrading/upstaging who should be recommended for multiparametric magnetic resonance imaging.PATIENTS AND METHODS: Between 1992 and 2017, a total of 3571 men with GS6 prostate cancer were consecutively treated at a single institution with radical prostatectomy. Logistic regression multivariable analyses to determine the odds of upgrading and upstaging were performed, adjusting for age and year of diagnosis, clinical T category, prostate-specific antigen level, number of biopsy cores, and percentage of positive biopsy cores.RESULTS: Of 3571 men, the disease of 115 (3.22%), 245 (6.86%), and 254 (7.11%) was upgraded, was upstaged, or had positive surgical margins (R1), respectively. Older age at diagnosis was associated with an increased risk of upgrading disease to GS7 or higher, prostatectomy T3/T4, and R1 with adjusted odds ratios (95% confidence intervals) of 1.05 (1.01-1.08; P = .005), 1.02 (1.00-1.05; P = .048), and 1.02 (1.002-1.05; P = .03), respectively. Older age was associated with an increasing proportion of men with disease upgraded to GS7 or higher (T1c: P = .002; T2 or higher: P = .04) or upstaged to pT3/4 or pT2R1 (T1c: P = .02; T2 or higher: P = .02) among men with ≥ 33% but not < 33% positive biopsy cores.CONCLUSION: Before initiating active surveillance, performing multiparametric magnetic resonance imaging in otherwise healthy older men with GS6 prostate cancer and ≥ 33% positive biopsy cores should be considered.

AB - PURPOSE: To identify a subset of men with Gleason score (GS) 6 prostate cancer who are at high risk for upgrading/upstaging who should be recommended for multiparametric magnetic resonance imaging.PATIENTS AND METHODS: Between 1992 and 2017, a total of 3571 men with GS6 prostate cancer were consecutively treated at a single institution with radical prostatectomy. Logistic regression multivariable analyses to determine the odds of upgrading and upstaging were performed, adjusting for age and year of diagnosis, clinical T category, prostate-specific antigen level, number of biopsy cores, and percentage of positive biopsy cores.RESULTS: Of 3571 men, the disease of 115 (3.22%), 245 (6.86%), and 254 (7.11%) was upgraded, was upstaged, or had positive surgical margins (R1), respectively. Older age at diagnosis was associated with an increased risk of upgrading disease to GS7 or higher, prostatectomy T3/T4, and R1 with adjusted odds ratios (95% confidence intervals) of 1.05 (1.01-1.08; P = .005), 1.02 (1.00-1.05; P = .048), and 1.02 (1.002-1.05; P = .03), respectively. Older age was associated with an increasing proportion of men with disease upgraded to GS7 or higher (T1c: P = .002; T2 or higher: P = .04) or upstaged to pT3/4 or pT2R1 (T1c: P = .02; T2 or higher: P = .02) among men with ≥ 33% but not < 33% positive biopsy cores.CONCLUSION: Before initiating active surveillance, performing multiparametric magnetic resonance imaging in otherwise healthy older men with GS6 prostate cancer and ≥ 33% positive biopsy cores should be considered.

KW - Age Factors

KW - Aged

KW - Biopsy, Large-Core Needle

KW - Case-Control Studies

KW - Humans

KW - Logistic Models

KW - Male

KW - Margins of Excision

KW - Middle Aged

KW - Multiparametric Magnetic Resonance Imaging/methods

KW - Neoplasm Grading

KW - Neoplasm Staging

KW - Prostate-Specific Antigen/blood

KW - Prostatectomy/methods

KW - Prostatic Neoplasms/blood

U2 - 10.1016/j.clgc.2019.07.018

DO - 10.1016/j.clgc.2019.07.018

M3 - SCORING: Journal article

C2 - 31601512

VL - 17

SP - e1116-e1121

JO - CLIN GENITOURIN CANC

JF - CLIN GENITOURIN CANC

SN - 1558-7673

IS - 6

ER -