Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT).
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Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). / Hoogduijn, Martin J; Popp, Felix C; Grohnert, Anja; Crop, Meindert J; van Rhijn, Marieke; Rowshani, Ajda T; Eggenhofer, Elke; Renner, Philipp; Reinders, Marlies E; Rabelink, Ton J; van der Laan, Luc J W; Dor, Frank J M F; Ijzermans, Jan N M; Genever, Paul G; Lange, Claudia; Durrbach, Antoine; Houtgraaf, Jaco H; Christ, Bruno; Seifert, Martina; Shagidulin, Murat; Donckier, Vincent; Deans, Robert; Ringden, Olle; Perico, Norberto; Remuzzi, Giuseppe; Bartholomew, Amelia; Schlitt, Hans J; Weimar, Willem; Baan, Carla C; Dahlke, Marc H; MISOT Study Group.
In: TRANSPLANTATION, Vol. 90, No. 2, 2, 2010, p. 124-126.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT).
AU - Hoogduijn, Martin J
AU - Popp, Felix C
AU - Grohnert, Anja
AU - Crop, Meindert J
AU - van Rhijn, Marieke
AU - Rowshani, Ajda T
AU - Eggenhofer, Elke
AU - Renner, Philipp
AU - Reinders, Marlies E
AU - Rabelink, Ton J
AU - van der Laan, Luc J W
AU - Dor, Frank J M F
AU - Ijzermans, Jan N M
AU - Genever, Paul G
AU - Lange, Claudia
AU - Durrbach, Antoine
AU - Houtgraaf, Jaco H
AU - Christ, Bruno
AU - Seifert, Martina
AU - Shagidulin, Murat
AU - Donckier, Vincent
AU - Deans, Robert
AU - Ringden, Olle
AU - Perico, Norberto
AU - Remuzzi, Giuseppe
AU - Bartholomew, Amelia
AU - Schlitt, Hans J
AU - Weimar, Willem
AU - Baan, Carla C
AU - Dahlke, Marc H
AU - MISOT Study Group
PY - 2010
Y1 - 2010
N2 - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
AB - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
KW - Humans
KW - T-Lymphocytes immunology
KW - Immunophenotyping
KW - Immunosuppression methods
KW - Cell Culture Techniques
KW - Graft Survival physiology
KW - Kidney Transplantation immunology
KW - Liver Transplantation immunology
KW - Mesenchymal Stem Cell Transplantation methods
KW - Mesenchymal Stem Cells cytology
KW - Organ Transplantation methods
KW - Safety
KW - Tissue Therapy methods
KW - Humans
KW - T-Lymphocytes immunology
KW - Immunophenotyping
KW - Immunosuppression methods
KW - Cell Culture Techniques
KW - Graft Survival physiology
KW - Kidney Transplantation immunology
KW - Liver Transplantation immunology
KW - Mesenchymal Stem Cell Transplantation methods
KW - Mesenchymal Stem Cells cytology
KW - Organ Transplantation methods
KW - Safety
KW - Tissue Therapy methods
U2 - 10.1097/TP.0b013e3181ea4240
DO - 10.1097/TP.0b013e3181ea4240
M3 - SCORING: Journal article
C2 - 20606604
VL - 90
SP - 124
EP - 126
JO - TRANSPLANTATION
JF - TRANSPLANTATION
SN - 0041-1337
IS - 2
M1 - 2
ER -