Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?

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Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system? / Kellner, Michael; Wortmann, Viola; Salzwedel, Cornelie; Kober, David; Petzoldt, Martin; Urbanowicz, Tatiana; Pulic, Mersija ; Boelmans, Kai; Yassouridis, Alexander; Wiedemann, Klaus.

In: PSYCHIAT RES, Vol. 239, 30.05.2016, p. 222-5.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{84eca736aaf146de931b0e4132c1a132,
title = "Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?",
abstract = "Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.",
keywords = "Journal Article",
author = "Michael Kellner and Viola Wortmann and Cornelie Salzwedel and David Kober and Martin Petzoldt and Tatiana Urbanowicz and Mersija Pulic and Kai Boelmans and Alexander Yassouridis and Klaus Wiedemann",
note = "Copyright {\textcopyright} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = may,
day = "30",
doi = "10.1016/j.psychres.2016.03.033",
language = "English",
volume = "239",
pages = "222--5",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?

AU - Kellner, Michael

AU - Wortmann, Viola

AU - Salzwedel, Cornelie

AU - Kober, David

AU - Petzoldt, Martin

AU - Urbanowicz, Tatiana

AU - Pulic, Mersija

AU - Boelmans, Kai

AU - Yassouridis, Alexander

AU - Wiedemann, Klaus

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/5/30

Y1 - 2016/5/30

N2 - Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.

AB - Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.

KW - Journal Article

U2 - 10.1016/j.psychres.2016.03.033

DO - 10.1016/j.psychres.2016.03.033

M3 - SCORING: Journal article

C2 - 27031591

VL - 239

SP - 222

EP - 225

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

ER -