Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?
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Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system? / Kellner, Michael; Wortmann, Viola; Salzwedel, Cornelie; Kober, David; Petzoldt, Martin; Urbanowicz, Tatiana; Pulic, Mersija ; Boelmans, Kai; Yassouridis, Alexander; Wiedemann, Klaus.
In: PSYCHIAT RES, Vol. 239, 30.05.2016, p. 222-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Adrenocorticotropic hormone in serial cerebrospinal fluid in man - Subject to acute regulation by the hypothalamic-pituitary-adrenocortical system?
AU - Kellner, Michael
AU - Wortmann, Viola
AU - Salzwedel, Cornelie
AU - Kober, David
AU - Petzoldt, Martin
AU - Urbanowicz, Tatiana
AU - Pulic, Mersija
AU - Boelmans, Kai
AU - Yassouridis, Alexander
AU - Wiedemann, Klaus
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/5/30
Y1 - 2016/5/30
N2 - Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.
AB - Acute regulation of adrenocorticotropic hormone (ACTH) in cerebrospinal fluid (CSF) by the hypothalamic-pituitary-adrenocortical system has not been investigated in man. In a pilot study in healthy male volunteers we measured ACTH every twenty minutes in serial CSF for three hours after an intravenous placebo, hydrocortisone (100mg) or insulin (2mg/kg) injection. No acute inhibitory or stimulatory effects of these interventions were discovered. Our results corroborate previous findings in rhesus monkeys. The regulation of CSF ACTH and its potential relevance for behavioral alterations in health and disease (e.g. major depression or anorexia nervosa) in humans need further study.
KW - Journal Article
U2 - 10.1016/j.psychres.2016.03.033
DO - 10.1016/j.psychres.2016.03.033
M3 - SCORING: Journal article
C2 - 27031591
VL - 239
SP - 222
EP - 225
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
ER -