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Adolescent impulsivity phenotypes characterized by distinct brain networks.

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Adolescent impulsivity phenotypes characterized by distinct brain networks. / Whelan, Robert; Conrod, Patricia J; Poline, Jean-Baptiste; Lourdusamy, Anbarasu; Banaschewski, Tobias; Barker, Gareth J; Bellgrove, Mark A; Büchel, Christian; Byrne, Mark; Cummins, Tarrant D R; Fauth-Bühler, Mira; Flor, Herta; Gallinat, Jürgen; Heinz, Andreas; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Lalor, Edmund C; Lathrop, Mark; Loth, Eva; Nees, Frauke; Paus, Tomas; Rietschel, Marcella; Smolka, Michael N; Spanagel, Rainer; Stephens, David N; Struve, Maren; Thyreau, Benjamin; Vollstaedt-Klein, Sabine; Robbins, Trevor W; Schumann, Gunter; Garavan, Hugh; Consortium, IMAGEN.

In: NAT NEUROSCI, Vol. 15, No. 6, 6, 2012, p. 920-925.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Whelan, R, Conrod, PJ, Poline, J-B, Lourdusamy, A, Banaschewski, T, Barker, GJ, Bellgrove, MA, Büchel, C, Byrne, M, Cummins, TDR, Fauth-Bühler, M, Flor, H, Gallinat, J, Heinz, A, Ittermann, B, Mann, K, Martinot, J-L, Lalor, EC, Lathrop, M, Loth, E, Nees, F, Paus, T, Rietschel, M, Smolka, MN, Spanagel, R, Stephens, DN, Struve, M, Thyreau, B, Vollstaedt-Klein, S, Robbins, TW, Schumann, G, Garavan, H & Consortium, IMAGEN 2012, 'Adolescent impulsivity phenotypes characterized by distinct brain networks.', NAT NEUROSCI, vol. 15, no. 6, 6, pp. 920-925. <http://www.ncbi.nlm.nih.gov/pubmed/22544311?dopt=Citation>

APA

Whelan, R., Conrod, P. J., Poline, J-B., Lourdusamy, A., Banaschewski, T., Barker, G. J., Bellgrove, M. A., Büchel, C., Byrne, M., Cummins, T. D. R., Fauth-Bühler, M., Flor, H., Gallinat, J., Heinz, A., Ittermann, B., Mann, K., Martinot, J-L., Lalor, E. C., Lathrop, M., ... Consortium, IMAGEN. (2012). Adolescent impulsivity phenotypes characterized by distinct brain networks. NAT NEUROSCI, 15(6), 920-925. [6]. http://www.ncbi.nlm.nih.gov/pubmed/22544311?dopt=Citation

Vancouver

Whelan R, Conrod PJ, Poline J-B, Lourdusamy A, Banaschewski T, Barker GJ et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. NAT NEUROSCI. 2012;15(6):920-925. 6.

Bibtex

@article{4eecf87427824d6ea27b2dce82f3e7df,
title = "Adolescent impulsivity phenotypes characterized by distinct brain networks.",
abstract = "The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.",
keywords = "Humans, Male, Female, Adolescent, Magnetic Resonance Imaging, Phenotype, Polymorphism, Single Nucleotide, Factor Analysis, Statistical, Image Interpretation, Computer-Assisted, *Brain Mapping, Brain/*physiology, Nerve Net/*physiology, Attention Deficit Disorder with Hyperactivity/genetics/physiopathology, Impulsive Behavior/genetics/*physiopathology, Norepinephrine Plasma Membrane Transport Proteins/genetics, Substance-Related Disorders/genetics/physiopathology, Humans, Male, Female, Adolescent, Magnetic Resonance Imaging, Phenotype, Polymorphism, Single Nucleotide, Factor Analysis, Statistical, Image Interpretation, Computer-Assisted, *Brain Mapping, Brain/*physiology, Nerve Net/*physiology, Attention Deficit Disorder with Hyperactivity/genetics/physiopathology, Impulsive Behavior/genetics/*physiopathology, Norepinephrine Plasma Membrane Transport Proteins/genetics, Substance-Related Disorders/genetics/physiopathology",
author = "Robert Whelan and Conrod, {Patricia J} and Jean-Baptiste Poline and Anbarasu Lourdusamy and Tobias Banaschewski and Barker, {Gareth J} and Bellgrove, {Mark A} and Christian B{\"u}chel and Mark Byrne and Cummins, {Tarrant D R} and Mira Fauth-B{\"u}hler and Herta Flor and J{\"u}rgen Gallinat and Andreas Heinz and Bernd Ittermann and Karl Mann and Jean-Luc Martinot and Lalor, {Edmund C} and Mark Lathrop and Eva Loth and Frauke Nees and Tomas Paus and Marcella Rietschel and Smolka, {Michael N} and Rainer Spanagel and Stephens, {David N} and Maren Struve and Benjamin Thyreau and Sabine Vollstaedt-Klein and Robbins, {Trevor W} and Gunter Schumann and Hugh Garavan and IMAGEN Consortium",
year = "2012",
language = "English",
volume = "15",
pages = "920--925",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Adolescent impulsivity phenotypes characterized by distinct brain networks.

AU - Whelan, Robert

AU - Conrod, Patricia J

AU - Poline, Jean-Baptiste

AU - Lourdusamy, Anbarasu

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bellgrove, Mark A

AU - Büchel, Christian

AU - Byrne, Mark

AU - Cummins, Tarrant D R

AU - Fauth-Bühler, Mira

AU - Flor, Herta

AU - Gallinat, Jürgen

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Mann, Karl

AU - Martinot, Jean-Luc

AU - Lalor, Edmund C

AU - Lathrop, Mark

AU - Loth, Eva

AU - Nees, Frauke

AU - Paus, Tomas

AU - Rietschel, Marcella

AU - Smolka, Michael N

AU - Spanagel, Rainer

AU - Stephens, David N

AU - Struve, Maren

AU - Thyreau, Benjamin

AU - Vollstaedt-Klein, Sabine

AU - Robbins, Trevor W

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Consortium, IMAGEN

PY - 2012

Y1 - 2012

N2 - The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.

AB - The impulsive behavior that is often characteristic of adolescence may reflect underlying neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is plausible that distinct brain networks contribute to its different cognitive, clinical and behavioral aspects. As these networks have not yet been described, we identified distinct cortical and subcortical networks underlying successful inhibitions and inhibition failures in a large sample (n = 1,896) of 14-year-old adolescents. Different networks were associated with drug use (n = 1,593) and attention-deficit hyperactivity disorder symptoms (n = 342). Hypofunctioning of a specific orbitofrontal cortical network was associated with likelihood of initiating drug use in early adolescence. Right inferior frontal activity was related to the speed of the inhibition process (n = 826) and use of illegal substances and associated with genetic variation in a norepinephrine transporter gene (n = 819). Our results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.

KW - Humans

KW - Male

KW - Female

KW - Adolescent

KW - Magnetic Resonance Imaging

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Factor Analysis, Statistical

KW - Image Interpretation, Computer-Assisted

KW - Brain Mapping

KW - Brain/physiology

KW - Nerve Net/physiology

KW - Attention Deficit Disorder with Hyperactivity/genetics/physiopathology

KW - Impulsive Behavior/genetics/physiopathology

KW - Norepinephrine Plasma Membrane Transport Proteins/genetics

KW - Substance-Related Disorders/genetics/physiopathology

KW - Humans

KW - Male

KW - Female

KW - Adolescent

KW - Magnetic Resonance Imaging

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Factor Analysis, Statistical

KW - Image Interpretation, Computer-Assisted

KW - Brain Mapping

KW - Brain/physiology

KW - Nerve Net/physiology

KW - Attention Deficit Disorder with Hyperactivity/genetics/physiopathology

KW - Impulsive Behavior/genetics/physiopathology

KW - Norepinephrine Plasma Membrane Transport Proteins/genetics

KW - Substance-Related Disorders/genetics/physiopathology

M3 - SCORING: Journal article

VL - 15

SP - 920

EP - 925

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 6

M1 - 6

ER -