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ADMA and arginine derivatives in relation to non-invasive vascular function in the general population

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ADMA and arginine derivatives in relation to non-invasive vascular function in the general population. / Baum, Christina; Johannsen, Silke S; Zeller, Tanja; Atzler, Dorothee; Ojeda, Francisco M; Wild, Philipp S; Sinning, Christoph R; Lackner, Karl J; Gori, Tommaso; Schwedhelm, Edzard; Böger, Rainer H; Blankenberg, Stefan; Münzel, Thomas; Schnabel, Renate B; Gutenberg Health Study investigators.

In: ATHEROSCLEROSIS, Vol. 244, 01.2016, p. 149-56.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baum, C, Johannsen, SS, Zeller, T, Atzler, D, Ojeda, FM, Wild, PS, Sinning, CR, Lackner, KJ, Gori, T, Schwedhelm, E, Böger, RH, Blankenberg, S, Münzel, T, Schnabel, RB & Gutenberg Health Study investigators 2016, 'ADMA and arginine derivatives in relation to non-invasive vascular function in the general population', ATHEROSCLEROSIS, vol. 244, pp. 149-56. https://doi.org/10.1016/j.atherosclerosis.2015.10.101

APA

Baum, C., Johannsen, S. S., Zeller, T., Atzler, D., Ojeda, F. M., Wild, P. S., Sinning, C. R., Lackner, K. J., Gori, T., Schwedhelm, E., Böger, R. H., Blankenberg, S., Münzel, T., Schnabel, R. B., & Gutenberg Health Study investigators (2016). ADMA and arginine derivatives in relation to non-invasive vascular function in the general population. ATHEROSCLEROSIS, 244, 149-56. https://doi.org/10.1016/j.atherosclerosis.2015.10.101

Vancouver

Baum C, Johannsen SS, Zeller T, Atzler D, Ojeda FM, Wild PS et al. ADMA and arginine derivatives in relation to non-invasive vascular function in the general population. ATHEROSCLEROSIS. 2016 Jan;244:149-56. https://doi.org/10.1016/j.atherosclerosis.2015.10.101

Bibtex

@article{5102c46c2a3947bdbbddd3e5b6ea1a18,
title = "ADMA and arginine derivatives in relation to non-invasive vascular function in the general population",
abstract = "OBJECTIVE: Nitric oxide produced from l-arginine is central to vascular homeostasis. Little is known about the relationship between arginine derivatives including asymmetric dimethylarginine (ADMA) and non-invasive vascular function measures in the general population.APPROACH AND RESULTS: In 5000 individuals (median age 56; 25th/75th percentile: 46, 65; 49% women) taking part in the population-based Gutenberg Health Study (Mainz area, Germany), we measured the relationship between the arginine derivatives asymmetric dimethylarginine (ADMA), N-monomethyl l-arginine (NMMA), symmetric dimethylarginine (SDMA) and l-arginine with flow-mediated dilation (FMD) and peripheral arterial tonometry (PAT). Weak bivariate correlations were observed between all measured arginine derivatives and vascular function measures, except of l-arginine and FMD and SDMA and PAT ratio. In multivariate adjusted linear regression analyses we could show statistically significant relationships between arginine derivatives and vascular function measures, which were influenced by age, sex and body mass index (BMI). Thus, a negative relationship between ADMA and FMD in females who were normal (beta: -0.095, P < 0.001) to overweight (beta: -0.071, P < 0.001) and a negative association of SDMA and FMD for middle-aged females was seen. The relationship between ADMA and PAT was negative for males who were normal (beta: -0.089, P < 0.001) to overweight (beta: -0.051, P = 0.007) and positive for obese females (beta: 0.073, P = 0.021).CONCLUSIONS: We showed small but significant correlations between ADMA and related arginine derivatives and non-invasive vascular function measures representative of different vascular regions. The associations were markedly influenced by age, sex and BMI. These findings support a complex interplay of arginine metabolism and vascular function.",
author = "Christina Baum and Johannsen, {Silke S} and Tanja Zeller and Dorothee Atzler and Ojeda, {Francisco M} and Wild, {Philipp S} and Sinning, {Christoph R} and Lackner, {Karl J} and Tommaso Gori and Edzard Schwedhelm and B{\"o}ger, {Rainer H} and Stefan Blankenberg and Thomas M{\"u}nzel and Schnabel, {Renate B} and {Gutenberg Health Study investigators}",
note = "Copyright {\textcopyright} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = jan,
doi = "10.1016/j.atherosclerosis.2015.10.101",
language = "English",
volume = "244",
pages = "149--56",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - ADMA and arginine derivatives in relation to non-invasive vascular function in the general population

AU - Baum, Christina

AU - Johannsen, Silke S

AU - Zeller, Tanja

AU - Atzler, Dorothee

AU - Ojeda, Francisco M

AU - Wild, Philipp S

AU - Sinning, Christoph R

AU - Lackner, Karl J

AU - Gori, Tommaso

AU - Schwedhelm, Edzard

AU - Böger, Rainer H

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Schnabel, Renate B

AU - Gutenberg Health Study investigators

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/1

Y1 - 2016/1

N2 - OBJECTIVE: Nitric oxide produced from l-arginine is central to vascular homeostasis. Little is known about the relationship between arginine derivatives including asymmetric dimethylarginine (ADMA) and non-invasive vascular function measures in the general population.APPROACH AND RESULTS: In 5000 individuals (median age 56; 25th/75th percentile: 46, 65; 49% women) taking part in the population-based Gutenberg Health Study (Mainz area, Germany), we measured the relationship between the arginine derivatives asymmetric dimethylarginine (ADMA), N-monomethyl l-arginine (NMMA), symmetric dimethylarginine (SDMA) and l-arginine with flow-mediated dilation (FMD) and peripheral arterial tonometry (PAT). Weak bivariate correlations were observed between all measured arginine derivatives and vascular function measures, except of l-arginine and FMD and SDMA and PAT ratio. In multivariate adjusted linear regression analyses we could show statistically significant relationships between arginine derivatives and vascular function measures, which were influenced by age, sex and body mass index (BMI). Thus, a negative relationship between ADMA and FMD in females who were normal (beta: -0.095, P < 0.001) to overweight (beta: -0.071, P < 0.001) and a negative association of SDMA and FMD for middle-aged females was seen. The relationship between ADMA and PAT was negative for males who were normal (beta: -0.089, P < 0.001) to overweight (beta: -0.051, P = 0.007) and positive for obese females (beta: 0.073, P = 0.021).CONCLUSIONS: We showed small but significant correlations between ADMA and related arginine derivatives and non-invasive vascular function measures representative of different vascular regions. The associations were markedly influenced by age, sex and BMI. These findings support a complex interplay of arginine metabolism and vascular function.

AB - OBJECTIVE: Nitric oxide produced from l-arginine is central to vascular homeostasis. Little is known about the relationship between arginine derivatives including asymmetric dimethylarginine (ADMA) and non-invasive vascular function measures in the general population.APPROACH AND RESULTS: In 5000 individuals (median age 56; 25th/75th percentile: 46, 65; 49% women) taking part in the population-based Gutenberg Health Study (Mainz area, Germany), we measured the relationship between the arginine derivatives asymmetric dimethylarginine (ADMA), N-monomethyl l-arginine (NMMA), symmetric dimethylarginine (SDMA) and l-arginine with flow-mediated dilation (FMD) and peripheral arterial tonometry (PAT). Weak bivariate correlations were observed between all measured arginine derivatives and vascular function measures, except of l-arginine and FMD and SDMA and PAT ratio. In multivariate adjusted linear regression analyses we could show statistically significant relationships between arginine derivatives and vascular function measures, which were influenced by age, sex and body mass index (BMI). Thus, a negative relationship between ADMA and FMD in females who were normal (beta: -0.095, P < 0.001) to overweight (beta: -0.071, P < 0.001) and a negative association of SDMA and FMD for middle-aged females was seen. The relationship between ADMA and PAT was negative for males who were normal (beta: -0.089, P < 0.001) to overweight (beta: -0.051, P = 0.007) and positive for obese females (beta: 0.073, P = 0.021).CONCLUSIONS: We showed small but significant correlations between ADMA and related arginine derivatives and non-invasive vascular function measures representative of different vascular regions. The associations were markedly influenced by age, sex and BMI. These findings support a complex interplay of arginine metabolism and vascular function.

U2 - 10.1016/j.atherosclerosis.2015.10.101

DO - 10.1016/j.atherosclerosis.2015.10.101

M3 - SCORING: Journal article

C2 - 26638011

VL - 244

SP - 149

EP - 156

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

ER -