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Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors

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Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. / Blessmann, Marco; Gröbe, Alexander; Quaas, Alexander; Kaifi, Jussuf T; Mistakidis, Georgios; Bernreuther, Christian; Sauter, Guido; Gros, Stephanie; Rawnaq, Tamina; Friedrich, Reinhard; Mautner, Victor F; Smeets, Ralf; Heiland, Max; Schachner, Melitta; Izbicki, Jakob R.

In: OR SURG OR MED OR PA, Vol. 113, No. 2, 01.02.2012, p. 239-44.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Blessmann, M, Gröbe, A, Quaas, A, Kaifi, JT, Mistakidis, G, Bernreuther, C, Sauter, G, Gros, S, Rawnaq, T, Friedrich, R, Mautner, VF, Smeets, R, Heiland, M, Schachner, M & Izbicki, JR 2012, 'Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors', OR SURG OR MED OR PA, vol. 113, no. 2, pp. 239-44. https://doi.org/10.1016/j.tripleo.2011.04.019

APA

Blessmann, M., Gröbe, A., Quaas, A., Kaifi, J. T., Mistakidis, G., Bernreuther, C., Sauter, G., Gros, S., Rawnaq, T., Friedrich, R., Mautner, V. F., Smeets, R., Heiland, M., Schachner, M., & Izbicki, J. R. (2012). Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. OR SURG OR MED OR PA, 113(2), 239-44. https://doi.org/10.1016/j.tripleo.2011.04.019

Vancouver

Blessmann M, Gröbe A, Quaas A, Kaifi JT, Mistakidis G, Bernreuther C et al. Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. OR SURG OR MED OR PA. 2012 Feb 1;113(2):239-44. https://doi.org/10.1016/j.tripleo.2011.04.019

Bibtex

@article{ff177b6c808a4541b6f0211214f2960d,
title = "Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors",
abstract = "Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is caused by a disorder of a single gene on chromosome 17 that usually restrains cell division. A sequence that is frequently associated with NF-1 is tumor progression from neurofibromas to malignant peripheral nerve sheath tumors (MPNSTs). The aim of this study was to determine the expression of the neural L1 cell adhesion molecule in dermal-diffuse neurofibromas, plexiform neurofibromas, and MPNSTs of NF-1. We retrospectively analyzed surgically resected primary tumors, including 20 dermal neurofibromas, 23 plexiform neurofibromas, and 17 MPNSTs, by immunohistochemistry in paraffin sections of NF-1 tumors with the use of the L1-specific monoclonal antibody UJ127, which does not cross-react with other members of the L1 family. Immunostainings for CD34 and S100 were included to distinguish and allocate L1-expressing Schwann cells and perineural (specialized) fibroblasts. Our data showed that L1 is highly expressed in all benign NF-1 tumors and in some but not all MPNSTs. Furthermore, we demonstrated a correlation between L1 expression and differentiation grade of MPNSTs. There was a significant trend toward lower or nondetectable expression in the poorly differentiated MPNSTs, in contrast to all other tumor entities so far investigated, in which L1 expression correlated positive with malignancy, except for juvenile but not adult-derived neuroblastomas. Future studies are warranted to elucidate the molecular basis of the varying effects of the degree of L1 expression, receptor, and signal transduction mechanisms in different tumors.",
keywords = "Adolescent, Adult, Aged, Cell Transformation, Neoplastic, Child, Child, Preschool, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Infant, Male, Mast Cells, Middle Aged, Nerve Sheath Neoplasms, Neural Cell Adhesion Molecule L1, Neurofibroma, Neurofibromatosis 1, Retrospective Studies, Young Adult",
author = "Marco Blessmann and Alexander Gr{\"o}be and Alexander Quaas and Kaifi, {Jussuf T} and Georgios Mistakidis and Christian Bernreuther and Guido Sauter and Stephanie Gros and Tamina Rawnaq and Reinhard Friedrich and Mautner, {Victor F} and Ralf Smeets and Max Heiland and Melitta Schachner and Izbicki, {Jakob R}",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2012",
month = feb,
day = "1",
doi = "10.1016/j.tripleo.2011.04.019",
language = "English",
volume = "113",
pages = "239--44",
journal = "OR SURG OR MED OR PA",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "2",

}

RIS

TY - JOUR

T1 - Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors

AU - Blessmann, Marco

AU - Gröbe, Alexander

AU - Quaas, Alexander

AU - Kaifi, Jussuf T

AU - Mistakidis, Georgios

AU - Bernreuther, Christian

AU - Sauter, Guido

AU - Gros, Stephanie

AU - Rawnaq, Tamina

AU - Friedrich, Reinhard

AU - Mautner, Victor F

AU - Smeets, Ralf

AU - Heiland, Max

AU - Schachner, Melitta

AU - Izbicki, Jakob R

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is caused by a disorder of a single gene on chromosome 17 that usually restrains cell division. A sequence that is frequently associated with NF-1 is tumor progression from neurofibromas to malignant peripheral nerve sheath tumors (MPNSTs). The aim of this study was to determine the expression of the neural L1 cell adhesion molecule in dermal-diffuse neurofibromas, plexiform neurofibromas, and MPNSTs of NF-1. We retrospectively analyzed surgically resected primary tumors, including 20 dermal neurofibromas, 23 plexiform neurofibromas, and 17 MPNSTs, by immunohistochemistry in paraffin sections of NF-1 tumors with the use of the L1-specific monoclonal antibody UJ127, which does not cross-react with other members of the L1 family. Immunostainings for CD34 and S100 were included to distinguish and allocate L1-expressing Schwann cells and perineural (specialized) fibroblasts. Our data showed that L1 is highly expressed in all benign NF-1 tumors and in some but not all MPNSTs. Furthermore, we demonstrated a correlation between L1 expression and differentiation grade of MPNSTs. There was a significant trend toward lower or nondetectable expression in the poorly differentiated MPNSTs, in contrast to all other tumor entities so far investigated, in which L1 expression correlated positive with malignancy, except for juvenile but not adult-derived neuroblastomas. Future studies are warranted to elucidate the molecular basis of the varying effects of the degree of L1 expression, receptor, and signal transduction mechanisms in different tumors.

AB - Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is caused by a disorder of a single gene on chromosome 17 that usually restrains cell division. A sequence that is frequently associated with NF-1 is tumor progression from neurofibromas to malignant peripheral nerve sheath tumors (MPNSTs). The aim of this study was to determine the expression of the neural L1 cell adhesion molecule in dermal-diffuse neurofibromas, plexiform neurofibromas, and MPNSTs of NF-1. We retrospectively analyzed surgically resected primary tumors, including 20 dermal neurofibromas, 23 plexiform neurofibromas, and 17 MPNSTs, by immunohistochemistry in paraffin sections of NF-1 tumors with the use of the L1-specific monoclonal antibody UJ127, which does not cross-react with other members of the L1 family. Immunostainings for CD34 and S100 were included to distinguish and allocate L1-expressing Schwann cells and perineural (specialized) fibroblasts. Our data showed that L1 is highly expressed in all benign NF-1 tumors and in some but not all MPNSTs. Furthermore, we demonstrated a correlation between L1 expression and differentiation grade of MPNSTs. There was a significant trend toward lower or nondetectable expression in the poorly differentiated MPNSTs, in contrast to all other tumor entities so far investigated, in which L1 expression correlated positive with malignancy, except for juvenile but not adult-derived neuroblastomas. Future studies are warranted to elucidate the molecular basis of the varying effects of the degree of L1 expression, receptor, and signal transduction mechanisms in different tumors.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cell Transformation, Neoplastic

KW - Child

KW - Child, Preschool

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - Infant

KW - Male

KW - Mast Cells

KW - Middle Aged

KW - Nerve Sheath Neoplasms

KW - Neural Cell Adhesion Molecule L1

KW - Neurofibroma

KW - Neurofibromatosis 1

KW - Retrospective Studies

KW - Young Adult

U2 - 10.1016/j.tripleo.2011.04.019

DO - 10.1016/j.tripleo.2011.04.019

M3 - SCORING: Journal article

C2 - 22677742

VL - 113

SP - 239

EP - 244

JO - OR SURG OR MED OR PA

JF - OR SURG OR MED OR PA

SN - 2212-4403

IS - 2

ER -