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Adenosine receptor antagonists including caffeine alter fetal brain development in mice

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Adenosine receptor antagonists including caffeine alter fetal brain development in mice. / Silva, Carla G; Métin, Christine; Fazeli, Walid; Machado, Nuno J; Darmopil, Sanja; Launay, Pierre-Serge; Ghestem, Antoine; Nesa, Marie-Pascale; Bassot, Emilie; Szabó, Eszter; Baqi, Younis; Müller, Christa E; Tomé, Angelo R; Ivanov, Anton; Isbrandt, Dirk; Zilberter, Yuri; Cunha, Rodrigo A; Esclapez, Monique; Bernard, Christophe.

In: SCI TRANSL MED, Vol. 5, No. 197, 07.08.2013, p. 197ra104.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Silva, CG, Métin, C, Fazeli, W, Machado, NJ, Darmopil, S, Launay, P-S, Ghestem, A, Nesa, M-P, Bassot, E, Szabó, E, Baqi, Y, Müller, CE, Tomé, AR, Ivanov, A, Isbrandt, D, Zilberter, Y, Cunha, RA, Esclapez, M & Bernard, C 2013, 'Adenosine receptor antagonists including caffeine alter fetal brain development in mice', SCI TRANSL MED, vol. 5, no. 197, pp. 197ra104. https://doi.org/10.1126/scitranslmed.3006258

APA

Silva, C. G., Métin, C., Fazeli, W., Machado, N. J., Darmopil, S., Launay, P-S., Ghestem, A., Nesa, M-P., Bassot, E., Szabó, E., Baqi, Y., Müller, C. E., Tomé, A. R., Ivanov, A., Isbrandt, D., Zilberter, Y., Cunha, R. A., Esclapez, M., & Bernard, C. (2013). Adenosine receptor antagonists including caffeine alter fetal brain development in mice. SCI TRANSL MED, 5(197), 197ra104. https://doi.org/10.1126/scitranslmed.3006258

Vancouver

Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay P-S et al. Adenosine receptor antagonists including caffeine alter fetal brain development in mice. SCI TRANSL MED. 2013 Aug 7;5(197):197ra104. https://doi.org/10.1126/scitranslmed.3006258

Bibtex

@article{5d3d5091271f433b8f26710ed6e7c6ab,
title = "Adenosine receptor antagonists including caffeine alter fetal brain development in mice",
abstract = "Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators of adenosine receptors affect neural development, we exposed mouse dams to a subtype-selective adenosine type 2A receptor (A2AR) antagonist or to caffeine, a naturally occurring adenosine receptor antagonist, during pregnancy and lactation. We observed delayed migration and insertion of γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry during the first postnatal week in offspring of dams treated with the A2AR antagonist or caffeine. This was associated with increased neuronal network excitability and increased susceptibility to seizures in response to a seizure-inducing agent. Adult offspring of mouse dams exposed to A2AR antagonists during pregnancy and lactation displayed loss of hippocampal GABA neurons and some cognitive deficits. These results demonstrate that exposure to A2AR antagonists including caffeine during pregnancy and lactation in rodents may have adverse effects on the neural development of their offspring.",
keywords = "Aging, Animals, Animals, Newborn, Brain, Caffeine, Cell Movement, Cognition Disorders, Disease Susceptibility, Female, Fetus, GABAergic Neurons, Glutamates, Green Fluorescent Proteins, Haplorhini, Hippocampus, Mice, Nerve Net, Pregnancy, Purinergic P1 Receptor Antagonists, Rats, Receptors, Adenosine A2, Seizures, Telencephalon",
author = "Silva, {Carla G} and Christine M{\'e}tin and Walid Fazeli and Machado, {Nuno J} and Sanja Darmopil and Pierre-Serge Launay and Antoine Ghestem and Marie-Pascale Nesa and Emilie Bassot and Eszter Szab{\'o} and Younis Baqi and M{\"u}ller, {Christa E} and Tom{\'e}, {Angelo R} and Anton Ivanov and Dirk Isbrandt and Yuri Zilberter and Cunha, {Rodrigo A} and Monique Esclapez and Christophe Bernard",
year = "2013",
month = aug,
day = "7",
doi = "10.1126/scitranslmed.3006258",
language = "English",
volume = "5",
pages = "197ra104",
journal = "SCI TRANSL MED",
issn = "1946-6234",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "197",

}

RIS

TY - JOUR

T1 - Adenosine receptor antagonists including caffeine alter fetal brain development in mice

AU - Silva, Carla G

AU - Métin, Christine

AU - Fazeli, Walid

AU - Machado, Nuno J

AU - Darmopil, Sanja

AU - Launay, Pierre-Serge

AU - Ghestem, Antoine

AU - Nesa, Marie-Pascale

AU - Bassot, Emilie

AU - Szabó, Eszter

AU - Baqi, Younis

AU - Müller, Christa E

AU - Tomé, Angelo R

AU - Ivanov, Anton

AU - Isbrandt, Dirk

AU - Zilberter, Yuri

AU - Cunha, Rodrigo A

AU - Esclapez, Monique

AU - Bernard, Christophe

PY - 2013/8/7

Y1 - 2013/8/7

N2 - Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators of adenosine receptors affect neural development, we exposed mouse dams to a subtype-selective adenosine type 2A receptor (A2AR) antagonist or to caffeine, a naturally occurring adenosine receptor antagonist, during pregnancy and lactation. We observed delayed migration and insertion of γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry during the first postnatal week in offspring of dams treated with the A2AR antagonist or caffeine. This was associated with increased neuronal network excitability and increased susceptibility to seizures in response to a seizure-inducing agent. Adult offspring of mouse dams exposed to A2AR antagonists during pregnancy and lactation displayed loss of hippocampal GABA neurons and some cognitive deficits. These results demonstrate that exposure to A2AR antagonists including caffeine during pregnancy and lactation in rodents may have adverse effects on the neural development of their offspring.

AB - Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators of adenosine receptors affect neural development, we exposed mouse dams to a subtype-selective adenosine type 2A receptor (A2AR) antagonist or to caffeine, a naturally occurring adenosine receptor antagonist, during pregnancy and lactation. We observed delayed migration and insertion of γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry during the first postnatal week in offspring of dams treated with the A2AR antagonist or caffeine. This was associated with increased neuronal network excitability and increased susceptibility to seizures in response to a seizure-inducing agent. Adult offspring of mouse dams exposed to A2AR antagonists during pregnancy and lactation displayed loss of hippocampal GABA neurons and some cognitive deficits. These results demonstrate that exposure to A2AR antagonists including caffeine during pregnancy and lactation in rodents may have adverse effects on the neural development of their offspring.

KW - Aging

KW - Animals

KW - Animals, Newborn

KW - Brain

KW - Caffeine

KW - Cell Movement

KW - Cognition Disorders

KW - Disease Susceptibility

KW - Female

KW - Fetus

KW - GABAergic Neurons

KW - Glutamates

KW - Green Fluorescent Proteins

KW - Haplorhini

KW - Hippocampus

KW - Mice

KW - Nerve Net

KW - Pregnancy

KW - Purinergic P1 Receptor Antagonists

KW - Rats

KW - Receptors, Adenosine A2

KW - Seizures

KW - Telencephalon

U2 - 10.1126/scitranslmed.3006258

DO - 10.1126/scitranslmed.3006258

M3 - SCORING: Journal article

C2 - 23926202

VL - 5

SP - 197ra104

JO - SCI TRANSL MED

JF - SCI TRANSL MED

SN - 1946-6234

IS - 197

ER -