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Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.

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Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. / Tsui, Tung Yu; Lau, Chi-Keung; Ma, Jian; Glockzin, Gabriel; Obed, Aiman; Schlitt, Hans-J; Fan, Sheung-Tat.

In: WORLD J GASTROENTERO, Vol. 12, No. 13, 13, 2006, p. 2016-2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tsui, TY, Lau, C-K, Ma, J, Glockzin, G, Obed, A, Schlitt, H-J & Fan, S-T 2006, 'Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.', WORLD J GASTROENTERO, vol. 12, no. 13, 13, pp. 2016-2023. <http://www.ncbi.nlm.nih.gov/pubmed/16610050?dopt=Citation>

APA

Tsui, T. Y., Lau, C-K., Ma, J., Glockzin, G., Obed, A., Schlitt, H-J., & Fan, S-T. (2006). Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. WORLD J GASTROENTERO, 12(13), 2016-2023. [13]. http://www.ncbi.nlm.nih.gov/pubmed/16610050?dopt=Citation

Vancouver

Tsui TY, Lau C-K, Ma J, Glockzin G, Obed A, Schlitt H-J et al. Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. WORLD J GASTROENTERO. 2006;12(13):2016-2023. 13.

Bibtex

@article{0af026abd12649e9bd87192a1d05cf5b,
title = "Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.",
abstract = "AIM: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1x 10(12) vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. RESULTS: Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells (HSCs) in rAAV/HO-1-transduced livers. CONCLUSION: Enhancement of HO activity in the livers suppresses the development of cirrhosis.",
author = "Tsui, {Tung Yu} and Chi-Keung Lau and Jian Ma and Gabriel Glockzin and Aiman Obed and Hans-J Schlitt and Sheung-Tat Fan",
year = "2006",
language = "Deutsch",
volume = "12",
pages = "2016--2023",
journal = "WORLD J GASTROENTERO",
issn = "1007-9327",
publisher = "WJG Press",
number = "13",

}

RIS

TY - JOUR

T1 - Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats.

AU - Tsui, Tung Yu

AU - Lau, Chi-Keung

AU - Ma, Jian

AU - Glockzin, Gabriel

AU - Obed, Aiman

AU - Schlitt, Hans-J

AU - Fan, Sheung-Tat

PY - 2006

Y1 - 2006

N2 - AIM: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1x 10(12) vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. RESULTS: Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells (HSCs) in rAAV/HO-1-transduced livers. CONCLUSION: Enhancement of HO activity in the livers suppresses the development of cirrhosis.

AB - AIM: To test the hypothesis that enhancement of the activity of heme oxygenase can interfere with processes of fibrogenesis associated with recurrent liver injury, we investigated the therapeutic potential of over-expression of heme oxygense-1 in a CCl(4)-induced micronodular cirrhosis model. METHODS: Recombinant adeno-associated viruses carrying rat HO-1 or GFP gene were generated. 1x 10(12) vg of adeno-associated viruses were administered through portal injection at the time of the induction of liver fibrosis. RESULTS: Conditioning the rat liver with over-expression of HO-1 by rAAV/HO-1 significantly increased the HO enzymatic activities in a stable manner. The development of micronodular cirrhosis was significantly inhibited in rAAV/HO-1-transduced animals as compared to controls. Portal hypertension was markedly diminished in rAAV/HO-1-transduced animals as compared to controls, whereas there are no significant changes in systolic blood pressure. This finding was accompanied with improved liver biochemistry, less infiltrating macrophages and less activated hepatic stellate cells (HSCs) in rAAV/HO-1-transduced livers. CONCLUSION: Enhancement of HO activity in the livers suppresses the development of cirrhosis.

M3 - SCORING: Zeitschriftenaufsatz

VL - 12

SP - 2016

EP - 2023

JO - WORLD J GASTROENTERO

JF - WORLD J GASTROENTERO

SN - 1007-9327

IS - 13

M1 - 13

ER -