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Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy

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Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy. / Böhm, Katharina; Tennstedt, Pierre; Beyer, Burkhard; Schiffmann, Jonas; Beckmann, Ann; Michl, Uwe; Beyersdorff, Dirk; Budäus, Lars; Graefen, Markus; Karakiewicz, Pierre I; Salomon, Georg.

In: WORLD J UROL, Vol. 34, No. 6, 01.06.2016, p. 805-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Böhm, K, Tennstedt, P, Beyer, B, Schiffmann, J, Beckmann, A, Michl, U, Beyersdorff, D, Budäus, L, Graefen, M, Karakiewicz, PI & Salomon, G 2016, 'Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy', WORLD J UROL, vol. 34, no. 6, pp. 805-10. https://doi.org/10.1007/s00345-015-1714-1

APA

Böhm, K., Tennstedt, P., Beyer, B., Schiffmann, J., Beckmann, A., Michl, U., Beyersdorff, D., Budäus, L., Graefen, M., Karakiewicz, P. I., & Salomon, G. (2016). Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy. WORLD J UROL, 34(6), 805-10. https://doi.org/10.1007/s00345-015-1714-1

Vancouver

Böhm K, Tennstedt P, Beyer B, Schiffmann J, Beckmann A, Michl U et al. Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy. WORLD J UROL. 2016 Jun 1;34(6):805-10. https://doi.org/10.1007/s00345-015-1714-1

Bibtex

@article{8259e5ec768e4263af2210e92fe9ad85,
title = "Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy",
abstract = "PURPOSE: To assess whether real-time elastography-targeted biopsy (RTE-bx) may help to correctly assign Gleason grade at radical prostatectomy (RP) and to compare discriminant properties of systematic biopsy alone (sbx) versus combination with RTE-bx (comb-bx) to distinguish between postoperatively favorable (Gleason 3 + 3, pT2, Nx/0) and postoperatively unfavorable (Gleason ≥4 + 4) prostate cancer (PCa) at RP.PATIENTS AND METHODS: Overall, 259 patients diagnosed with PCa at systematic biopsy in combination with RTE-bx underwent RP between 2008 and 2011. Gleason Score derived from sbx versus comb-bx was compared to the gold-standard RP, and discriminant properties were assessed. Specificity gains were examined for sbx versus comb-bx when the endpoint consisted of postoperatively favorable PCa at RP. Sensitivity gains were examined, when analyses focused on postoperatively unfavorable PCa.RESULTS: Comb-bx resulted in higher correct overall Gleason assignment (68.3 vs. 56.7 %, p = 0.008) than sbx. Similarly, lower rates of undergrading (21.2 vs. 36.3 %, p < 0.001) were recorded. Specificity gains with comb-bx were 10 % (92 vs. 82 %, p = 0.004) for postoperatively favorable PCa. Comb-bx resulted in 31 % sensitivity gains relative to sbx (94 vs. 63 %, p = 0.03), when postoperatively unfavorable PCa was the endpoint.CONCLUSION: The agreement between biopsy and pathology Gleason Score was significantly higher for comb-bx than sbx. Additionally, comb-bx reduced the rate of false positives in the diagnosis of favorable PCa. Rates of correctly classified unfavorable PCa at RP were also higher for comb-bx. Those data indicate that comb-bx is useful in clinical practice.",
author = "Katharina B{\"o}hm and Pierre Tennstedt and Burkhard Beyer and Jonas Schiffmann and Ann Beckmann and Uwe Michl and Dirk Beyersdorff and Lars Bud{\"a}us and Markus Graefen and Karakiewicz, {Pierre I} and Georg Salomon",
year = "2016",
month = jun,
day = "1",
doi = "10.1007/s00345-015-1714-1",
language = "English",
volume = "34",
pages = "805--10",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Additional elastography-targeted biopsy improves the agreement between biopsy Gleason grade and Gleason grade at radical prostatectomy

AU - Böhm, Katharina

AU - Tennstedt, Pierre

AU - Beyer, Burkhard

AU - Schiffmann, Jonas

AU - Beckmann, Ann

AU - Michl, Uwe

AU - Beyersdorff, Dirk

AU - Budäus, Lars

AU - Graefen, Markus

AU - Karakiewicz, Pierre I

AU - Salomon, Georg

PY - 2016/6/1

Y1 - 2016/6/1

N2 - PURPOSE: To assess whether real-time elastography-targeted biopsy (RTE-bx) may help to correctly assign Gleason grade at radical prostatectomy (RP) and to compare discriminant properties of systematic biopsy alone (sbx) versus combination with RTE-bx (comb-bx) to distinguish between postoperatively favorable (Gleason 3 + 3, pT2, Nx/0) and postoperatively unfavorable (Gleason ≥4 + 4) prostate cancer (PCa) at RP.PATIENTS AND METHODS: Overall, 259 patients diagnosed with PCa at systematic biopsy in combination with RTE-bx underwent RP between 2008 and 2011. Gleason Score derived from sbx versus comb-bx was compared to the gold-standard RP, and discriminant properties were assessed. Specificity gains were examined for sbx versus comb-bx when the endpoint consisted of postoperatively favorable PCa at RP. Sensitivity gains were examined, when analyses focused on postoperatively unfavorable PCa.RESULTS: Comb-bx resulted in higher correct overall Gleason assignment (68.3 vs. 56.7 %, p = 0.008) than sbx. Similarly, lower rates of undergrading (21.2 vs. 36.3 %, p < 0.001) were recorded. Specificity gains with comb-bx were 10 % (92 vs. 82 %, p = 0.004) for postoperatively favorable PCa. Comb-bx resulted in 31 % sensitivity gains relative to sbx (94 vs. 63 %, p = 0.03), when postoperatively unfavorable PCa was the endpoint.CONCLUSION: The agreement between biopsy and pathology Gleason Score was significantly higher for comb-bx than sbx. Additionally, comb-bx reduced the rate of false positives in the diagnosis of favorable PCa. Rates of correctly classified unfavorable PCa at RP were also higher for comb-bx. Those data indicate that comb-bx is useful in clinical practice.

AB - PURPOSE: To assess whether real-time elastography-targeted biopsy (RTE-bx) may help to correctly assign Gleason grade at radical prostatectomy (RP) and to compare discriminant properties of systematic biopsy alone (sbx) versus combination with RTE-bx (comb-bx) to distinguish between postoperatively favorable (Gleason 3 + 3, pT2, Nx/0) and postoperatively unfavorable (Gleason ≥4 + 4) prostate cancer (PCa) at RP.PATIENTS AND METHODS: Overall, 259 patients diagnosed with PCa at systematic biopsy in combination with RTE-bx underwent RP between 2008 and 2011. Gleason Score derived from sbx versus comb-bx was compared to the gold-standard RP, and discriminant properties were assessed. Specificity gains were examined for sbx versus comb-bx when the endpoint consisted of postoperatively favorable PCa at RP. Sensitivity gains were examined, when analyses focused on postoperatively unfavorable PCa.RESULTS: Comb-bx resulted in higher correct overall Gleason assignment (68.3 vs. 56.7 %, p = 0.008) than sbx. Similarly, lower rates of undergrading (21.2 vs. 36.3 %, p < 0.001) were recorded. Specificity gains with comb-bx were 10 % (92 vs. 82 %, p = 0.004) for postoperatively favorable PCa. Comb-bx resulted in 31 % sensitivity gains relative to sbx (94 vs. 63 %, p = 0.03), when postoperatively unfavorable PCa was the endpoint.CONCLUSION: The agreement between biopsy and pathology Gleason Score was significantly higher for comb-bx than sbx. Additionally, comb-bx reduced the rate of false positives in the diagnosis of favorable PCa. Rates of correctly classified unfavorable PCa at RP were also higher for comb-bx. Those data indicate that comb-bx is useful in clinical practice.

U2 - 10.1007/s00345-015-1714-1

DO - 10.1007/s00345-015-1714-1

M3 - SCORING: Journal article

C2 - 26481227

VL - 34

SP - 805

EP - 810

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 6

ER -