ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study.

  • Valerie Zielinski
  • Markus Brunner
  • Gregor Heiduschka
  • Sven Schneider
  • Rudolf Seemann
  • Boban Erovic
  • Dietmar Thurnher

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Abstract

A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found to be overexpressed in squamous cell carcinomas of the lung. A new study showed that ADAM8 is significantly overexpressed in metastasis of squamous cell carcinomas of the head and neck (HNSCC).

Bibliographical data

Original languageEnglish
ISSN1471-2407
Publication statusPublished - 2012
pubmed 22369429