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Acute-phase serum amyloid A as a marker of insulin resistance in mice.

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Acute-phase serum amyloid A as a marker of insulin resistance in mice. / Scheja, Ludger; Heese, Barbara; Zitzer, Heike; Michael, Mervyn D; Siesky, Angela M; Pospisil, Heike; Beisiegel, Ulrike; Seedorf, Klaus.

In: Exp Diabetes Res, Vol. 2008, 2008, p. 230837.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Scheja, L, Heese, B, Zitzer, H, Michael, MD, Siesky, AM, Pospisil, H, Beisiegel, U & Seedorf, K 2008, 'Acute-phase serum amyloid A as a marker of insulin resistance in mice.', Exp Diabetes Res, vol. 2008, pp. 230837. https://doi.org/10.1155/2008/230837

APA

Scheja, L., Heese, B., Zitzer, H., Michael, M. D., Siesky, A. M., Pospisil, H., Beisiegel, U., & Seedorf, K. (2008). Acute-phase serum amyloid A as a marker of insulin resistance in mice. Exp Diabetes Res, 2008, 230837. https://doi.org/10.1155/2008/230837

Vancouver

Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H et al. Acute-phase serum amyloid A as a marker of insulin resistance in mice. Exp Diabetes Res. 2008;2008:230837. https://doi.org/10.1155/2008/230837

Bibtex

@article{3997d6e0f68a4944ba615501d79abf05,
title = "Acute-phase serum amyloid A as a marker of insulin resistance in mice.",
abstract = "Acute-phase serum amyloid A (A-SAA) was shown recently to correlate with obesity and insulin resistance in humans. However, the mechanisms linking obesity-associated inflammation and elevated plasma A-SAA to insulin resistance are poorly understood. Using high-fat diet- (HFD-) fed mice, we found that plasma A-SAA was increased early upon HFD feeding and was tightly associated with systemic insulin resistance. Plasma A-SAA elevation was due to induction of Saa1 and Saa2 expression in liver but not in adipose tissue. In adipose tissue Saa3 was the predominant isoform and the earliest inflammatory marker induced, suggesting it is important for initiation of adipose tissue inflammation. To assess the potential impact of A-SAA on adipose tissue insulin resistance, we treated 3T3-L1 adipocytes with recombinant A-SAA. Intriguingly, physiological levels of A-SAA caused alterations in gene expression closely resembling those observed in HFD-fed mice. Proinflammatory genes (Ccl2, Saa3) were induced while genes critical for insulin sensitivity (Irs1, Adipoq, Glut4) were down-regulated. Our data identify HFD-fed mice as a suitable model to study A-SAA as a biomarker and a novel possible mediator of insulin resistance.",
author = "Ludger Scheja and Barbara Heese and Heike Zitzer and Michael, {Mervyn D} and Siesky, {Angela M} and Heike Pospisil and Ulrike Beisiegel and Klaus Seedorf",
year = "2008",
doi = "10.1155/2008/230837",
language = "Deutsch",
volume = "2008",
pages = "230837",

}

RIS

TY - JOUR

T1 - Acute-phase serum amyloid A as a marker of insulin resistance in mice.

AU - Scheja, Ludger

AU - Heese, Barbara

AU - Zitzer, Heike

AU - Michael, Mervyn D

AU - Siesky, Angela M

AU - Pospisil, Heike

AU - Beisiegel, Ulrike

AU - Seedorf, Klaus

PY - 2008

Y1 - 2008

N2 - Acute-phase serum amyloid A (A-SAA) was shown recently to correlate with obesity and insulin resistance in humans. However, the mechanisms linking obesity-associated inflammation and elevated plasma A-SAA to insulin resistance are poorly understood. Using high-fat diet- (HFD-) fed mice, we found that plasma A-SAA was increased early upon HFD feeding and was tightly associated with systemic insulin resistance. Plasma A-SAA elevation was due to induction of Saa1 and Saa2 expression in liver but not in adipose tissue. In adipose tissue Saa3 was the predominant isoform and the earliest inflammatory marker induced, suggesting it is important for initiation of adipose tissue inflammation. To assess the potential impact of A-SAA on adipose tissue insulin resistance, we treated 3T3-L1 adipocytes with recombinant A-SAA. Intriguingly, physiological levels of A-SAA caused alterations in gene expression closely resembling those observed in HFD-fed mice. Proinflammatory genes (Ccl2, Saa3) were induced while genes critical for insulin sensitivity (Irs1, Adipoq, Glut4) were down-regulated. Our data identify HFD-fed mice as a suitable model to study A-SAA as a biomarker and a novel possible mediator of insulin resistance.

AB - Acute-phase serum amyloid A (A-SAA) was shown recently to correlate with obesity and insulin resistance in humans. However, the mechanisms linking obesity-associated inflammation and elevated plasma A-SAA to insulin resistance are poorly understood. Using high-fat diet- (HFD-) fed mice, we found that plasma A-SAA was increased early upon HFD feeding and was tightly associated with systemic insulin resistance. Plasma A-SAA elevation was due to induction of Saa1 and Saa2 expression in liver but not in adipose tissue. In adipose tissue Saa3 was the predominant isoform and the earliest inflammatory marker induced, suggesting it is important for initiation of adipose tissue inflammation. To assess the potential impact of A-SAA on adipose tissue insulin resistance, we treated 3T3-L1 adipocytes with recombinant A-SAA. Intriguingly, physiological levels of A-SAA caused alterations in gene expression closely resembling those observed in HFD-fed mice. Proinflammatory genes (Ccl2, Saa3) were induced while genes critical for insulin sensitivity (Irs1, Adipoq, Glut4) were down-regulated. Our data identify HFD-fed mice as a suitable model to study A-SAA as a biomarker and a novel possible mediator of insulin resistance.

U2 - 10.1155/2008/230837

DO - 10.1155/2008/230837

M3 - SCORING: Zeitschriftenaufsatz

VL - 2008

SP - 230837

ER -