Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
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Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders. / Atanackovic, Djordje; Nowottne, Ulrike; Freier, Eva; Weber, Cora Stefanie; Meyer, Sabrina; Bartels, Katrin; Hildebrandt, York; Cao, Yanran; Kröger, Nicolaus-Martin; Brunner-Weinzierl, Monika Christine; Bokemeyer, Carsten; Deter, Hans-Christian.
In: STRESS, Vol. 16, No. 4, 01.07.2013, p. 421-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
AU - Atanackovic, Djordje
AU - Nowottne, Ulrike
AU - Freier, Eva
AU - Weber, Cora Stefanie
AU - Meyer, Sabrina
AU - Bartels, Katrin
AU - Hildebrandt, York
AU - Cao, Yanran
AU - Kröger, Nicolaus-Martin
AU - Brunner-Weinzierl, Monika Christine
AU - Bokemeyer, Carsten
AU - Deter, Hans-Christian
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Acute psychological stress has primarily been investigated regarding its effects on conventional lymphocytes such as natural killer (NK) cells and CD4(+) and CD8(+) T cells. However, it might be important to focus on more "specialized" lymphocyte subsets, playing a role, for instance, in allergic conditions and autoimmunity, to identify links between stress, the immune system and somatic diseases. Using flow cytometry we determined frequencies of circulating T helper (Th)1-type (CD226(+)) and Th2-type (CRTH2(+)) T cells, γδ T cells, conventional CD56(+) natural killer T (NKT) cells and invariant NKT cells (iNKT) in healthy young males (N = 31; median age 26 years) undergoing a laboratory computer-based stressor lasting 12 min. We found that acute psychological stress induced a prolonged increase in CD4(+) and CD8(+) T cells expressing a Th2 phenotype. We also detected an acute increase in CD4(-) and CD8(-) double negative γδ T cells. Finally, we found that the well-known increase in NK cells under stressful conditions was paralleled by a significant increase in numbers of conventional CD56(+) NKT cells. In contrast, numbers of iNKT was not altered by stress. This study adds further evidence to a psychoneuroimmunological model proposing that under stressful conditions certain lymphocyte subsets, including iNKT and less mature T cells, are retained in lymphoid tissues while antigen-experienced effector-type T cells with a Th2 phenotype, γδ T cells and conventional CD56(+) NKT cells are mobilized into the peripheral blood. We suggest that in the case of frequent stress exposure, this might result in the promotion of, for example, allergic conditions.
AB - Acute psychological stress has primarily been investigated regarding its effects on conventional lymphocytes such as natural killer (NK) cells and CD4(+) and CD8(+) T cells. However, it might be important to focus on more "specialized" lymphocyte subsets, playing a role, for instance, in allergic conditions and autoimmunity, to identify links between stress, the immune system and somatic diseases. Using flow cytometry we determined frequencies of circulating T helper (Th)1-type (CD226(+)) and Th2-type (CRTH2(+)) T cells, γδ T cells, conventional CD56(+) natural killer T (NKT) cells and invariant NKT cells (iNKT) in healthy young males (N = 31; median age 26 years) undergoing a laboratory computer-based stressor lasting 12 min. We found that acute psychological stress induced a prolonged increase in CD4(+) and CD8(+) T cells expressing a Th2 phenotype. We also detected an acute increase in CD4(-) and CD8(-) double negative γδ T cells. Finally, we found that the well-known increase in NK cells under stressful conditions was paralleled by a significant increase in numbers of conventional CD56(+) NKT cells. In contrast, numbers of iNKT was not altered by stress. This study adds further evidence to a psychoneuroimmunological model proposing that under stressful conditions certain lymphocyte subsets, including iNKT and less mature T cells, are retained in lymphoid tissues while antigen-experienced effector-type T cells with a Th2 phenotype, γδ T cells and conventional CD56(+) NKT cells are mobilized into the peripheral blood. We suggest that in the case of frequent stress exposure, this might result in the promotion of, for example, allergic conditions.
KW - Adult
KW - Antigens, CD3
KW - Antigens, CD56
KW - Antigens, Differentiation, T-Lymphocyte
KW - Autoimmune Diseases
KW - Blood Pressure
KW - CD8-Positive T-Lymphocytes
KW - Heart Rate
KW - Humans
KW - Hypersensitivity
KW - Lymphocyte Subsets
KW - Male
KW - Natural Killer T-Cells
KW - Receptors, Antigen, T-Cell, gamma-delta
KW - Stress, Psychological
KW - Th2 Cells
U2 - 10.3109/10253890.2013.777702
DO - 10.3109/10253890.2013.777702
M3 - SCORING: Journal article
C2 - 23425210
VL - 16
SP - 421
EP - 428
JO - STRESS
JF - STRESS
SN - 1025-3890
IS - 4
ER -