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Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction

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Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction. / Franzen, Olaf; Baldus, Stephan; Rudolph, Volker; Meyer, Sven; Knap, Malgorzata; Koschyk, Dietmar; Treede, Hendrik; Barmeyer, Achim; Schofer, Joachim; Costard-Jäckle, Angelika; Schlüter, Michael; Reichenspurner, Hermann; Meinertz, Thomas.

In: EUR HEART J, Vol. 31, No. 11, 06.2010, p. 1373-1381.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Franzen, O, Baldus, S, Rudolph, V, Meyer, S, Knap, M, Koschyk, D, Treede, H, Barmeyer, A, Schofer, J, Costard-Jäckle, A, Schlüter, M, Reichenspurner, H & Meinertz, T 2010, 'Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction', EUR HEART J, vol. 31, no. 11, pp. 1373-1381. https://doi.org/10.1093/eurheartj/ehq050

APA

Franzen, O., Baldus, S., Rudolph, V., Meyer, S., Knap, M., Koschyk, D., Treede, H., Barmeyer, A., Schofer, J., Costard-Jäckle, A., Schlüter, M., Reichenspurner, H., & Meinertz, T. (2010). Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction. EUR HEART J, 31(11), 1373-1381. https://doi.org/10.1093/eurheartj/ehq050

Vancouver

Franzen O, Baldus S, Rudolph V, Meyer S, Knap M, Koschyk D et al. Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction. EUR HEART J. 2010 Jun;31(11):1373-1381. https://doi.org/10.1093/eurheartj/ehq050

Bibtex

@article{5f2dbcf65b6f482182edccd1a9966898,
title = "Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction",
abstract = "AIMS: We sought to assess the feasibility of catheter-based mitral valve repair using the MitraClip system in high-surgical-risk patients with mitral regurgitation (MR) > or =grade 3+.METHODS AND RESULTS: MitraClip therapy was performed in 51 consecutive patients [73 +/- 10 years; 34 (67%) men] with symptomatic functional [n = 35 (69%)] or organic MR [n = 16 (31%)]. Mean logistic EuroSCORE was 29 +/- 22%; Society of Thoracic Surgeons score was 15 +/- 11. Left ventricular (LV) ejection fraction was 36 +/- 17%. In 35 patients (69%), adverse mitral valve morphology and/or severe LV dysfunction were present. MitraClip implantation was successful in 49 patients (96%). Most patients [n = 34/49 (69%)] were treated with a single clip, whereas 14 patients (29%) received two clips and one patient received three clips. Mean device and fluoroscopy times were 105 +/- 65 min and 44 +/- 28 min, respectively. Procedure-related reduction in MR severity was one grade in 16 patients (31%), two grades in 24 patients (47%), and three grades in 9 patients (18%). Forty-four of the 49 successfully treated patients (90%) showed clinical improvement at discharge [NYHA functional class > or =III in 48 patients (98%) before and 16 patients (33%) after the procedure (P < 0.0001)]. There were no procedure-related major adverse events and no in-hospital mortality.CONCLUSION: Mitral valve repair using the MitraClip system was shown to be feasible in patients at high surgical risk primarily determined by an adverse mitral valve morphology and/or severe LV dysfunction.",
keywords = "Aged, Aged, 80 and over, Echocardiography, Doppler, Color, Echocardiography, Transesophageal, Feasibility Studies, Female, Hospitalization, Humans, Male, Middle Aged, Mitral Valve/pathology, Mitral Valve Annuloplasty/instrumentation, Mitral Valve Insufficiency/pathology, Postoperative Complications/etiology, Risk Factors, Surgical Instruments, Ventricular Dysfunction, Left/pathology",
author = "Olaf Franzen and Stephan Baldus and Volker Rudolph and Sven Meyer and Malgorzata Knap and Dietmar Koschyk and Hendrik Treede and Achim Barmeyer and Joachim Schofer and Angelika Costard-J{\"a}ckle and Michael Schl{\"u}ter and Hermann Reichenspurner and Thomas Meinertz",
year = "2010",
month = jun,
doi = "10.1093/eurheartj/ehq050",
language = "English",
volume = "31",
pages = "1373--1381",
journal = "EUR HEART J",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction

AU - Franzen, Olaf

AU - Baldus, Stephan

AU - Rudolph, Volker

AU - Meyer, Sven

AU - Knap, Malgorzata

AU - Koschyk, Dietmar

AU - Treede, Hendrik

AU - Barmeyer, Achim

AU - Schofer, Joachim

AU - Costard-Jäckle, Angelika

AU - Schlüter, Michael

AU - Reichenspurner, Hermann

AU - Meinertz, Thomas

PY - 2010/6

Y1 - 2010/6

N2 - AIMS: We sought to assess the feasibility of catheter-based mitral valve repair using the MitraClip system in high-surgical-risk patients with mitral regurgitation (MR) > or =grade 3+.METHODS AND RESULTS: MitraClip therapy was performed in 51 consecutive patients [73 +/- 10 years; 34 (67%) men] with symptomatic functional [n = 35 (69%)] or organic MR [n = 16 (31%)]. Mean logistic EuroSCORE was 29 +/- 22%; Society of Thoracic Surgeons score was 15 +/- 11. Left ventricular (LV) ejection fraction was 36 +/- 17%. In 35 patients (69%), adverse mitral valve morphology and/or severe LV dysfunction were present. MitraClip implantation was successful in 49 patients (96%). Most patients [n = 34/49 (69%)] were treated with a single clip, whereas 14 patients (29%) received two clips and one patient received three clips. Mean device and fluoroscopy times were 105 +/- 65 min and 44 +/- 28 min, respectively. Procedure-related reduction in MR severity was one grade in 16 patients (31%), two grades in 24 patients (47%), and three grades in 9 patients (18%). Forty-four of the 49 successfully treated patients (90%) showed clinical improvement at discharge [NYHA functional class > or =III in 48 patients (98%) before and 16 patients (33%) after the procedure (P < 0.0001)]. There were no procedure-related major adverse events and no in-hospital mortality.CONCLUSION: Mitral valve repair using the MitraClip system was shown to be feasible in patients at high surgical risk primarily determined by an adverse mitral valve morphology and/or severe LV dysfunction.

AB - AIMS: We sought to assess the feasibility of catheter-based mitral valve repair using the MitraClip system in high-surgical-risk patients with mitral regurgitation (MR) > or =grade 3+.METHODS AND RESULTS: MitraClip therapy was performed in 51 consecutive patients [73 +/- 10 years; 34 (67%) men] with symptomatic functional [n = 35 (69%)] or organic MR [n = 16 (31%)]. Mean logistic EuroSCORE was 29 +/- 22%; Society of Thoracic Surgeons score was 15 +/- 11. Left ventricular (LV) ejection fraction was 36 +/- 17%. In 35 patients (69%), adverse mitral valve morphology and/or severe LV dysfunction were present. MitraClip implantation was successful in 49 patients (96%). Most patients [n = 34/49 (69%)] were treated with a single clip, whereas 14 patients (29%) received two clips and one patient received three clips. Mean device and fluoroscopy times were 105 +/- 65 min and 44 +/- 28 min, respectively. Procedure-related reduction in MR severity was one grade in 16 patients (31%), two grades in 24 patients (47%), and three grades in 9 patients (18%). Forty-four of the 49 successfully treated patients (90%) showed clinical improvement at discharge [NYHA functional class > or =III in 48 patients (98%) before and 16 patients (33%) after the procedure (P < 0.0001)]. There were no procedure-related major adverse events and no in-hospital mortality.CONCLUSION: Mitral valve repair using the MitraClip system was shown to be feasible in patients at high surgical risk primarily determined by an adverse mitral valve morphology and/or severe LV dysfunction.

KW - Aged

KW - Aged, 80 and over

KW - Echocardiography, Doppler, Color

KW - Echocardiography, Transesophageal

KW - Feasibility Studies

KW - Female

KW - Hospitalization

KW - Humans

KW - Male

KW - Middle Aged

KW - Mitral Valve/pathology

KW - Mitral Valve Annuloplasty/instrumentation

KW - Mitral Valve Insufficiency/pathology

KW - Postoperative Complications/etiology

KW - Risk Factors

KW - Surgical Instruments

KW - Ventricular Dysfunction, Left/pathology

U2 - 10.1093/eurheartj/ehq050

DO - 10.1093/eurheartj/ehq050

M3 - SCORING: Journal article

C2 - 20219746

VL - 31

SP - 1373

EP - 1381

JO - EUR HEART J

JF - EUR HEART J

SN - 0195-668X

IS - 11

ER -