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Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation

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Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation. / Kahle, Ann-Kathrin; Klatt, Niklas; Jungen, Christiane; Dietenberger, Aaron; Kuklik, Pawel; Münkler, Paula; Willems, Stephan; Nikolaev, Viacheslav; Pauza, Dainius H; Scherschel, Katharina; Meyer, Christian.

In: JACC-CLIN ELECTROPHY, Vol. 9, No. 3, 03.2023, p. 371-384.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kahle, A-K, Klatt, N, Jungen, C, Dietenberger, A, Kuklik, P, Münkler, P, Willems, S, Nikolaev, V, Pauza, DH, Scherschel, K & Meyer, C 2023, 'Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation', JACC-CLIN ELECTROPHY, vol. 9, no. 3, pp. 371-384. https://doi.org/10.1016/j.jacep.2022.10.013

APA

Kahle, A-K., Klatt, N., Jungen, C., Dietenberger, A., Kuklik, P., Münkler, P., Willems, S., Nikolaev, V., Pauza, D. H., Scherschel, K., & Meyer, C. (2023). Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation. JACC-CLIN ELECTROPHY, 9(3), 371-384. https://doi.org/10.1016/j.jacep.2022.10.013

Vancouver

Kahle A-K, Klatt N, Jungen C, Dietenberger A, Kuklik P, Münkler P et al. Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation. JACC-CLIN ELECTROPHY. 2023 Mar;9(3):371-384. https://doi.org/10.1016/j.jacep.2022.10.013

Bibtex

@article{266363102dc640a1bcbd269be81151e4,
title = "Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation",
abstract = "BACKGROUND: The sympathetic nervous system plays an integral role in cardiac physiology. Nerve fibers innervating the left ventricle are amenable to transvenous catheter stimulation along the coronary sinus (CS).OBJECTIVES: The aim of the present study was to modulate left ventricular control by selective intracardiac sympathetic denervation.METHODS: First, the impact of epicardial CS ablation on cardiac electrophysiology was studied in a Langendorff model of decentralized murine hearts (n = 10 each, ablation and control groups). Second, the impact of transvenous, anatomically driven axotomy by catheter-based radiofrequency ablation via the CS was evaluated in healthy sheep (n = 8) before and during stellate ganglion stimulation.RESULTS: CS ablation prolonged epicardial ventricular refractory period without (41.8 ± 8.4 ms vs 53.0 ± 13.5 ms; P = 0.049) and with β1-2-adrenergic receptor blockade (47.8 ± 7.8 ms vs 73.1 ± 13.2 ms; P < 0.001) in mice. Supported by neuromorphological studies illustrating a circumferential CS neural network, intracardiac axotomy by catheter ablation via the CS in healthy sheep diminished the blood pressure increase during stellate ganglion stimulation (Δ systolic blood pressure 21.9 ± 10.9 mm Hg vs 10.5 ± 12.0 mm Hg; P = 0.023; Δ diastolic blood pressure 9.0 ± 5.5 mm Hg vs 3.0 ± 3.5 mm Hg; P = 0.039).CONCLUSIONS: Transvenous, anatomically driven axotomy targeting nerve fibers along the CS enables acute modulation of left ventricular control by selective intracardiac sympathetic denervation.",
author = "Ann-Kathrin Kahle and Niklas Klatt and Christiane Jungen and Aaron Dietenberger and Pawel Kuklik and Paula M{\"u}nkler and Stephan Willems and Viacheslav Nikolaev and Pauza, {Dainius H} and Katharina Scherschel and Christian Meyer",
note = "Copyright {\textcopyright} 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = mar,
doi = "10.1016/j.jacep.2022.10.013",
language = "English",
volume = "9",
pages = "371--384",
journal = "JACC-CLIN ELECTROPHY",
issn = "2405-500X",
publisher = "Elsevier USA",
number = "3",

}

RIS

TY - JOUR

T1 - Acute Modulation of Left Ventricular Control by Selective Intracardiac Sympathetic Denervation

AU - Kahle, Ann-Kathrin

AU - Klatt, Niklas

AU - Jungen, Christiane

AU - Dietenberger, Aaron

AU - Kuklik, Pawel

AU - Münkler, Paula

AU - Willems, Stephan

AU - Nikolaev, Viacheslav

AU - Pauza, Dainius H

AU - Scherschel, Katharina

AU - Meyer, Christian

N1 - Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2023/3

Y1 - 2023/3

N2 - BACKGROUND: The sympathetic nervous system plays an integral role in cardiac physiology. Nerve fibers innervating the left ventricle are amenable to transvenous catheter stimulation along the coronary sinus (CS).OBJECTIVES: The aim of the present study was to modulate left ventricular control by selective intracardiac sympathetic denervation.METHODS: First, the impact of epicardial CS ablation on cardiac electrophysiology was studied in a Langendorff model of decentralized murine hearts (n = 10 each, ablation and control groups). Second, the impact of transvenous, anatomically driven axotomy by catheter-based radiofrequency ablation via the CS was evaluated in healthy sheep (n = 8) before and during stellate ganglion stimulation.RESULTS: CS ablation prolonged epicardial ventricular refractory period without (41.8 ± 8.4 ms vs 53.0 ± 13.5 ms; P = 0.049) and with β1-2-adrenergic receptor blockade (47.8 ± 7.8 ms vs 73.1 ± 13.2 ms; P < 0.001) in mice. Supported by neuromorphological studies illustrating a circumferential CS neural network, intracardiac axotomy by catheter ablation via the CS in healthy sheep diminished the blood pressure increase during stellate ganglion stimulation (Δ systolic blood pressure 21.9 ± 10.9 mm Hg vs 10.5 ± 12.0 mm Hg; P = 0.023; Δ diastolic blood pressure 9.0 ± 5.5 mm Hg vs 3.0 ± 3.5 mm Hg; P = 0.039).CONCLUSIONS: Transvenous, anatomically driven axotomy targeting nerve fibers along the CS enables acute modulation of left ventricular control by selective intracardiac sympathetic denervation.

AB - BACKGROUND: The sympathetic nervous system plays an integral role in cardiac physiology. Nerve fibers innervating the left ventricle are amenable to transvenous catheter stimulation along the coronary sinus (CS).OBJECTIVES: The aim of the present study was to modulate left ventricular control by selective intracardiac sympathetic denervation.METHODS: First, the impact of epicardial CS ablation on cardiac electrophysiology was studied in a Langendorff model of decentralized murine hearts (n = 10 each, ablation and control groups). Second, the impact of transvenous, anatomically driven axotomy by catheter-based radiofrequency ablation via the CS was evaluated in healthy sheep (n = 8) before and during stellate ganglion stimulation.RESULTS: CS ablation prolonged epicardial ventricular refractory period without (41.8 ± 8.4 ms vs 53.0 ± 13.5 ms; P = 0.049) and with β1-2-adrenergic receptor blockade (47.8 ± 7.8 ms vs 73.1 ± 13.2 ms; P < 0.001) in mice. Supported by neuromorphological studies illustrating a circumferential CS neural network, intracardiac axotomy by catheter ablation via the CS in healthy sheep diminished the blood pressure increase during stellate ganglion stimulation (Δ systolic blood pressure 21.9 ± 10.9 mm Hg vs 10.5 ± 12.0 mm Hg; P = 0.023; Δ diastolic blood pressure 9.0 ± 5.5 mm Hg vs 3.0 ± 3.5 mm Hg; P = 0.039).CONCLUSIONS: Transvenous, anatomically driven axotomy targeting nerve fibers along the CS enables acute modulation of left ventricular control by selective intracardiac sympathetic denervation.

U2 - 10.1016/j.jacep.2022.10.013

DO - 10.1016/j.jacep.2022.10.013

M3 - SCORING: Journal article

C2 - 36752452

VL - 9

SP - 371

EP - 384

JO - JACC-CLIN ELECTROPHY

JF - JACC-CLIN ELECTROPHY

SN - 2405-500X

IS - 3

ER -