Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial.
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Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial. / Rudolph, Tanja Katharina; Ruempler, Kaike; Schwedhelm, Edzard; Tan-Andresen, Jing; Riederer, Ulrich; Böger, Rainer; Maas, Renke.
In: AM J CLIN NUTR, Vol. 86, No. 2, 2, 2007, p. 334-340.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial.
AU - Rudolph, Tanja Katharina
AU - Ruempler, Kaike
AU - Schwedhelm, Edzard
AU - Tan-Andresen, Jing
AU - Riederer, Ulrich
AU - Böger, Rainer
AU - Maas, Renke
PY - 2007
Y1 - 2007
N2 - BACKGROUND: High-fat meals have negative effects on endothelial function, but vitamin-rich side orders may prevent these negative effects. OBJECTIVE: The acute effects of conventional and alternative fast-food meals on vascular function and various cardiovascular biomarkers were investigated. DESIGN: In a crossover study, flow-mediated endothelium-dependent dilatation (FMD) and cardiovascular disease risk markers were investigated in 24 healthy volunteers before and 2 and 4 h after 3 fast-food meals: a conventional beef burger with French fries, ketchup, and carbonated lemon-flavored soda (meal 1); a vegetarian burger with French fries, ketchup, and carbonated lemon-flavored soda (meal 2); and a vegetarian burger with salad, fruit, yogurt, and orange juice (meal 3). RESULTS: FMD decreased after all 3 fast-food meals: the values were 9.7 +/- 2.5%, 7.5 +/- 3.5%, and 6.2 +/- 3.3% for meal 1; 9.2 +/- 3.4%, 7.1 +/- 3.4%, and 6.3 +/- 4.0% for meal 2; and 8.8 +/- 3.3%, 6.2 +/- 4.0%, and 6.8 +/- 4.3% for meal 3 at baseline, 2 h, and 4 h, respectively. There were significant intraindividual differences for time (P <0.001) but not for type of meal (P = 0.677). A postprandial increase in baseline diameter of the brachial artery was significant for time (P <0.001) but not for type of meal (P = 0.148). CONCLUSIONS: Against common expectations, a conventional beef burger meal and presumably healthier alternatives with or without vitamin-rich side orders did not differ significantly in their acute effects on vascular reactivity. The frequently reported postprandial decline in FMD may be attributed in part to a postprandial increase in baseline arterial diameter.
AB - BACKGROUND: High-fat meals have negative effects on endothelial function, but vitamin-rich side orders may prevent these negative effects. OBJECTIVE: The acute effects of conventional and alternative fast-food meals on vascular function and various cardiovascular biomarkers were investigated. DESIGN: In a crossover study, flow-mediated endothelium-dependent dilatation (FMD) and cardiovascular disease risk markers were investigated in 24 healthy volunteers before and 2 and 4 h after 3 fast-food meals: a conventional beef burger with French fries, ketchup, and carbonated lemon-flavored soda (meal 1); a vegetarian burger with French fries, ketchup, and carbonated lemon-flavored soda (meal 2); and a vegetarian burger with salad, fruit, yogurt, and orange juice (meal 3). RESULTS: FMD decreased after all 3 fast-food meals: the values were 9.7 +/- 2.5%, 7.5 +/- 3.5%, and 6.2 +/- 3.3% for meal 1; 9.2 +/- 3.4%, 7.1 +/- 3.4%, and 6.3 +/- 4.0% for meal 2; and 8.8 +/- 3.3%, 6.2 +/- 4.0%, and 6.8 +/- 4.3% for meal 3 at baseline, 2 h, and 4 h, respectively. There were significant intraindividual differences for time (P <0.001) but not for type of meal (P = 0.677). A postprandial increase in baseline diameter of the brachial artery was significant for time (P <0.001) but not for type of meal (P = 0.148). CONCLUSIONS: Against common expectations, a conventional beef burger meal and presumably healthier alternatives with or without vitamin-rich side orders did not differ significantly in their acute effects on vascular reactivity. The frequently reported postprandial decline in FMD may be attributed in part to a postprandial increase in baseline arterial diameter.
M3 - SCORING: Zeitschriftenaufsatz
VL - 86
SP - 334
EP - 340
JO - AM J CLIN NUTR
JF - AM J CLIN NUTR
SN - 0002-9165
IS - 2
M1 - 2
ER -