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Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension

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Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension. / Harbaum, Lars; Renk, Emilia; Yousef, Sara; Glatzel, Antonia; Lüneburg, Nicole; Hennigs, Jan K; Oqueka, Tim; Baumann, Hans J; Atanackovic, Djordje; Grünig, Ekkehard; Böger, Rainer H; Bokemeyer, Carsten; Klose, Hans.

In: BMC PULM MED, Vol. 16, No. 1, 11.11.2016, p. 145.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Harbaum, L, Renk, E, Yousef, S, Glatzel, A, Lüneburg, N, Hennigs, JK, Oqueka, T, Baumann, HJ, Atanackovic, D, Grünig, E, Böger, RH, Bokemeyer, C & Klose, H 2016, 'Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension', BMC PULM MED, vol. 16, no. 1, pp. 145. https://doi.org/10.1186/s12890-016-0301-6

APA

Harbaum, L., Renk, E., Yousef, S., Glatzel, A., Lüneburg, N., Hennigs, J. K., Oqueka, T., Baumann, H. J., Atanackovic, D., Grünig, E., Böger, R. H., Bokemeyer, C., & Klose, H. (2016). Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension. BMC PULM MED, 16(1), 145. https://doi.org/10.1186/s12890-016-0301-6

Vancouver

Harbaum L, Renk E, Yousef S, Glatzel A, Lüneburg N, Hennigs JK et al. Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension. BMC PULM MED. 2016 Nov 11;16(1):145. https://doi.org/10.1186/s12890-016-0301-6

Bibtex

@article{5de573fe7d5f4de183ff464d2cb180cb,
title = "Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension",
abstract = "BACKGROUND: Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients.METHODS: Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10 healthy subjects. Phenotypic characterization of peripheral blood mononuclear cells and circulating cytokines were assessed before, directly after and 1 h after exercise.RESULTS: Before exercise testing, IPAH patients showed elevated Th2 lymphocytes, regulatory T lymphocytes, IL-6, and TNF-alpha, whilst Th1/Th17 lymphocytes and IL-4 were reduced. In IPAH patients but not in healthy subject, exercise caused an immediate relative decrease of Th17 lymphocytes and a sustained reduction of IL-1-beta and IL-6. The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients.CONCLUSIONS: Exercise seems to be safe from an immune and inflammatory point of view in IPAH patients. Our results demonstrate that exercise does not aggravate the inflammatory state and seems to elicit an immune-modulating effect in IPAH patients.",
author = "Lars Harbaum and Emilia Renk and Sara Yousef and Antonia Glatzel and Nicole L{\"u}neburg and Hennigs, {Jan K} and Tim Oqueka and Baumann, {Hans J} and Djordje Atanackovic and Ekkehard Gr{\"u}nig and B{\"o}ger, {Rainer H} and Carsten Bokemeyer and Hans Klose",
year = "2016",
month = nov,
day = "11",
doi = "10.1186/s12890-016-0301-6",
language = "English",
volume = "16",
pages = "145",
journal = "BMC PULM MED",
issn = "1471-2466",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Acute effects of exercise on the inflammatory state in patients with idiopathic pulmonary arterial hypertension

AU - Harbaum, Lars

AU - Renk, Emilia

AU - Yousef, Sara

AU - Glatzel, Antonia

AU - Lüneburg, Nicole

AU - Hennigs, Jan K

AU - Oqueka, Tim

AU - Baumann, Hans J

AU - Atanackovic, Djordje

AU - Grünig, Ekkehard

AU - Böger, Rainer H

AU - Bokemeyer, Carsten

AU - Klose, Hans

PY - 2016/11/11

Y1 - 2016/11/11

N2 - BACKGROUND: Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients.METHODS: Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10 healthy subjects. Phenotypic characterization of peripheral blood mononuclear cells and circulating cytokines were assessed before, directly after and 1 h after exercise.RESULTS: Before exercise testing, IPAH patients showed elevated Th2 lymphocytes, regulatory T lymphocytes, IL-6, and TNF-alpha, whilst Th1/Th17 lymphocytes and IL-4 were reduced. In IPAH patients but not in healthy subject, exercise caused an immediate relative decrease of Th17 lymphocytes and a sustained reduction of IL-1-beta and IL-6. The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients.CONCLUSIONS: Exercise seems to be safe from an immune and inflammatory point of view in IPAH patients. Our results demonstrate that exercise does not aggravate the inflammatory state and seems to elicit an immune-modulating effect in IPAH patients.

AB - BACKGROUND: Exercise training positively influences exercise tolerance and functional capacity of patients with idiopathic pulmonary arterial hypertension (IPAH). However, the underlying mechanisms are unclear. We hypothesized that exercise modulates the activated inflammatory state found in IPAH patients.METHODS: Single cardiopulmonary exercise testing was performed in 16 IPAH patients and 10 healthy subjects. Phenotypic characterization of peripheral blood mononuclear cells and circulating cytokines were assessed before, directly after and 1 h after exercise.RESULTS: Before exercise testing, IPAH patients showed elevated Th2 lymphocytes, regulatory T lymphocytes, IL-6, and TNF-alpha, whilst Th1/Th17 lymphocytes and IL-4 were reduced. In IPAH patients but not in healthy subject, exercise caused an immediate relative decrease of Th17 lymphocytes and a sustained reduction of IL-1-beta and IL-6. The higher the decrease of IL-6 the higher was the peak oxygen consumption of IPAH patients.CONCLUSIONS: Exercise seems to be safe from an immune and inflammatory point of view in IPAH patients. Our results demonstrate that exercise does not aggravate the inflammatory state and seems to elicit an immune-modulating effect in IPAH patients.

U2 - 10.1186/s12890-016-0301-6

DO - 10.1186/s12890-016-0301-6

M3 - SCORING: Journal article

C2 - 27835955

VL - 16

SP - 145

JO - BMC PULM MED

JF - BMC PULM MED

SN - 1471-2466

IS - 1

ER -