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Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

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Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. / Ghiretti, Amy E; Thies, Edda; Tokito, Mariko K; Lin, Tianming; Ostap, E Michael; Kneussel, Matthias; Holzbaur, Erika L F.

In: NEURON, Vol. 92, No. 4, 23.11.2016, p. 857-872.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ghiretti, AE, Thies, E, Tokito, MK, Lin, T, Ostap, EM, Kneussel, M & Holzbaur, ELF 2016, 'Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B', NEURON, vol. 92, no. 4, pp. 857-872. https://doi.org/10.1016/j.neuron.2016.10.003

APA

Ghiretti, A. E., Thies, E., Tokito, M. K., Lin, T., Ostap, E. M., Kneussel, M., & Holzbaur, E. L. F. (2016). Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. NEURON, 92(4), 857-872. https://doi.org/10.1016/j.neuron.2016.10.003

Vancouver

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M et al. Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. NEURON. 2016 Nov 23;92(4):857-872. https://doi.org/10.1016/j.neuron.2016.10.003

Bibtex

@article{60b19a0a6da9471188f719035bac4db7,
title = "Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B",
abstract = "The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance between directed cargo trafficking and dynamic restructuring of the underlying microtubule tracks. How cytoskeletal components are able to dynamically regulate these processes to maintain this balance remains largely unknown. By combining single-molecule assays and live imaging in rat hippocampal neurons, we have identified the kinesin-4 KIF21B as a molecular regulator of activity-dependent trafficking and microtubule dynamicity in dendrites. We find that KIF21B contributes to the retrograde trafficking of brain-derived neurotrophic factor (BDNF)-TrkB complexes and also regulates microtubule dynamics through a separable, non-motor microtubule-binding domain. Neuronal activity enhances the motility of KIF21B at the expense of its role in cytoskeletal remodeling, the first example of a kinesin whose function is directly tuned to neuronal activity state. These studies suggest a model in which KIF21B navigates the complex cytoskeletal environment of dendrites by compartmentalizing functions in an activity-dependent manner.",
author = "Ghiretti, {Amy E} and Edda Thies and Tokito, {Mariko K} and Tianming Lin and Ostap, {E Michael} and Matthias Kneussel and Holzbaur, {Erika L F}",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = nov,
day = "23",
doi = "10.1016/j.neuron.2016.10.003",
language = "English",
volume = "92",
pages = "857--872",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B

AU - Ghiretti, Amy E

AU - Thies, Edda

AU - Tokito, Mariko K

AU - Lin, Tianming

AU - Ostap, E Michael

AU - Kneussel, Matthias

AU - Holzbaur, Erika L F

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/11/23

Y1 - 2016/11/23

N2 - The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance between directed cargo trafficking and dynamic restructuring of the underlying microtubule tracks. How cytoskeletal components are able to dynamically regulate these processes to maintain this balance remains largely unknown. By combining single-molecule assays and live imaging in rat hippocampal neurons, we have identified the kinesin-4 KIF21B as a molecular regulator of activity-dependent trafficking and microtubule dynamicity in dendrites. We find that KIF21B contributes to the retrograde trafficking of brain-derived neurotrophic factor (BDNF)-TrkB complexes and also regulates microtubule dynamics through a separable, non-motor microtubule-binding domain. Neuronal activity enhances the motility of KIF21B at the expense of its role in cytoskeletal remodeling, the first example of a kinesin whose function is directly tuned to neuronal activity state. These studies suggest a model in which KIF21B navigates the complex cytoskeletal environment of dendrites by compartmentalizing functions in an activity-dependent manner.

AB - The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance between directed cargo trafficking and dynamic restructuring of the underlying microtubule tracks. How cytoskeletal components are able to dynamically regulate these processes to maintain this balance remains largely unknown. By combining single-molecule assays and live imaging in rat hippocampal neurons, we have identified the kinesin-4 KIF21B as a molecular regulator of activity-dependent trafficking and microtubule dynamicity in dendrites. We find that KIF21B contributes to the retrograde trafficking of brain-derived neurotrophic factor (BDNF)-TrkB complexes and also regulates microtubule dynamics through a separable, non-motor microtubule-binding domain. Neuronal activity enhances the motility of KIF21B at the expense of its role in cytoskeletal remodeling, the first example of a kinesin whose function is directly tuned to neuronal activity state. These studies suggest a model in which KIF21B navigates the complex cytoskeletal environment of dendrites by compartmentalizing functions in an activity-dependent manner.

U2 - 10.1016/j.neuron.2016.10.003

DO - 10.1016/j.neuron.2016.10.003

M3 - SCORING: Journal article

C2 - 27817978

VL - 92

SP - 857

EP - 872

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 4

ER -