Research ExplorerPublicationsActive versus passive mechanisms in metastasis: do cancer ce...

Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?

Standard

Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? / Bockhorn, Maximilian; Jain, Rakesh K; Munn, Lance L.

In: LANCET ONCOL, Vol. 8, No. 5, 5, 01.05.2007, p. 444-448.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bockhorn, M, Jain, RK & Munn, LL 2007, 'Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?', LANCET ONCOL, vol. 8, no. 5, 5, pp. 444-448. https://doi.org/10.1016/S1470-2045(07)70140-7

APA

Bockhorn, M., Jain, R. K., & Munn, L. L. (2007). Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? LANCET ONCOL, 8(5), 444-448. [5]. https://doi.org/10.1016/S1470-2045(07)70140-7

Vancouver

Bockhorn M, Jain RK, Munn LL. Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? LANCET ONCOL. 2007 May 1;8(5):444-448. 5. https://doi.org/10.1016/S1470-2045(07)70140-7

Bibtex

@article{ed9551238a4e4eeb80c657183918a814,
title = "Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?",
abstract = "Although millions of cells are shed from a tumour every day, haematogenous metastasis is believed to be very inefficient. This inefficiency is widely assumed to be a result of the destruction of cells in the bloodstream by shear stress and the immune system and a slow rate of extravasation and proliferation in the stroma at a secondary site. Here, we propose that, whereas active intravasation of cells into the circulation is important in some tumours, others might shed cells passively into the blood or lymphatic vessels without the involvement of active cell migration. We discuss the evidence for and against this passive-shedding hypothesis and the implications for future treatments.",
keywords = "Blood Vessels, Cell Adhesion, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic",
author = "Maximilian Bockhorn and Jain, {Rakesh K} and Munn, {Lance L}",
year = "2007",
month = may,
day = "1",
doi = "10.1016/S1470-2045(07)70140-7",
language = "English",
volume = "8",
pages = "444--448",
journal = "LANCET ONCOL",
issn = "1470-2045",
publisher = "Lancet Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?

AU - Bockhorn, Maximilian

AU - Jain, Rakesh K

AU - Munn, Lance L

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Although millions of cells are shed from a tumour every day, haematogenous metastasis is believed to be very inefficient. This inefficiency is widely assumed to be a result of the destruction of cells in the bloodstream by shear stress and the immune system and a slow rate of extravasation and proliferation in the stroma at a secondary site. Here, we propose that, whereas active intravasation of cells into the circulation is important in some tumours, others might shed cells passively into the blood or lymphatic vessels without the involvement of active cell migration. We discuss the evidence for and against this passive-shedding hypothesis and the implications for future treatments.

AB - Although millions of cells are shed from a tumour every day, haematogenous metastasis is believed to be very inefficient. This inefficiency is widely assumed to be a result of the destruction of cells in the bloodstream by shear stress and the immune system and a slow rate of extravasation and proliferation in the stroma at a secondary site. Here, we propose that, whereas active intravasation of cells into the circulation is important in some tumours, others might shed cells passively into the blood or lymphatic vessels without the involvement of active cell migration. We discuss the evidence for and against this passive-shedding hypothesis and the implications for future treatments.

KW - Blood Vessels

KW - Cell Adhesion

KW - Humans

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplasms

KW - Neovascularization, Pathologic

U2 - 10.1016/S1470-2045(07)70140-7

DO - 10.1016/S1470-2045(07)70140-7

M3 - SCORING: Journal article

C2 - 17466902

VL - 8

SP - 444

EP - 448

JO - LANCET ONCOL

JF - LANCET ONCOL

SN - 1470-2045

IS - 5

M1 - 5

ER -