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Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice

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Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. / Santuccione, A C; Merlini, M; Shetty, A; Tackenberg, C; Bali, J; Ferretti, M T; McAfoose, J; Kulic, L; Bernreuther, C; Welt, T; Grimm, J; Glatzel, M; Rajendran, L; Hock, C; Nitsch, R M.

In: MOL PSYCHIATR, Vol. 18, No. 3, 01.03.2013, p. 358-68.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Santuccione, AC, Merlini, M, Shetty, A, Tackenberg, C, Bali, J, Ferretti, MT, McAfoose, J, Kulic, L, Bernreuther, C, Welt, T, Grimm, J, Glatzel, M, Rajendran, L, Hock, C & Nitsch, RM 2013, 'Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice', MOL PSYCHIATR, vol. 18, no. 3, pp. 358-68. https://doi.org/10.1038/mp.2012.70

APA

Santuccione, A. C., Merlini, M., Shetty, A., Tackenberg, C., Bali, J., Ferretti, M. T., McAfoose, J., Kulic, L., Bernreuther, C., Welt, T., Grimm, J., Glatzel, M., Rajendran, L., Hock, C., & Nitsch, R. M. (2013). Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. MOL PSYCHIATR, 18(3), 358-68. https://doi.org/10.1038/mp.2012.70

Vancouver

Santuccione AC, Merlini M, Shetty A, Tackenberg C, Bali J, Ferretti MT et al. Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice. MOL PSYCHIATR. 2013 Mar 1;18(3):358-68. https://doi.org/10.1038/mp.2012.70

Bibtex

@article{fef4a73418f149998a6adebe7992ab1c,
title = "Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice",
abstract = "Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ankyrin G (ankG); these correlated with slower rates of cognitive decline. Neuronal expression of ankG was higher in AD brains than in nondemented age-matched healthy control subjects. AnkG was present in exosomal vesicles, and it accumulated in β-amyloid plaques. Active immunization with ankG of arcAβ transgenic mice reduced brain β-amyloid pathology and increased brain levels of soluble Aβ(42). AnkG immunization induced a reduction in β-amyloid pathology, also in Swedish transgenic mice(.) Anti-ankG monoclonal antibodies reduced Aβ-induced loss of dendritic spines in hippocampal ArcAβ organotypic cultures. Together, these data established a role for ankG in the human adaptive immune response against resident brain proteins, and they show that ankG immunization reduces brain β-amyloid and its related neuropathology.",
keywords = "Alzheimer Disease, Amyloid beta-Peptides, Animals, Ankyrins, Antibodies, Antibodies, Monoclonal, Brain, Cells, Cultured, Hippocampus, Humans, Mice, Mice, Transgenic, Neurons, Peptide Fragments, Plaque, Amyloid, Vaccination",
author = "Santuccione, {A C} and M Merlini and A Shetty and C Tackenberg and J Bali and Ferretti, {M T} and J McAfoose and L Kulic and C Bernreuther and T Welt and J Grimm and M Glatzel and L Rajendran and C Hock and Nitsch, {R M}",
year = "2013",
month = mar,
day = "1",
doi = "10.1038/mp.2012.70",
language = "English",
volume = "18",
pages = "358--68",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice

AU - Santuccione, A C

AU - Merlini, M

AU - Shetty, A

AU - Tackenberg, C

AU - Bali, J

AU - Ferretti, M T

AU - McAfoose, J

AU - Kulic, L

AU - Bernreuther, C

AU - Welt, T

AU - Grimm, J

AU - Glatzel, M

AU - Rajendran, L

AU - Hock, C

AU - Nitsch, R M

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ankyrin G (ankG); these correlated with slower rates of cognitive decline. Neuronal expression of ankG was higher in AD brains than in nondemented age-matched healthy control subjects. AnkG was present in exosomal vesicles, and it accumulated in β-amyloid plaques. Active immunization with ankG of arcAβ transgenic mice reduced brain β-amyloid pathology and increased brain levels of soluble Aβ(42). AnkG immunization induced a reduction in β-amyloid pathology, also in Swedish transgenic mice(.) Anti-ankG monoclonal antibodies reduced Aβ-induced loss of dendritic spines in hippocampal ArcAβ organotypic cultures. Together, these data established a role for ankG in the human adaptive immune response against resident brain proteins, and they show that ankG immunization reduces brain β-amyloid and its related neuropathology.

AB - Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against the neuronal cytoskeletal protein ankyrin G (ankG); these correlated with slower rates of cognitive decline. Neuronal expression of ankG was higher in AD brains than in nondemented age-matched healthy control subjects. AnkG was present in exosomal vesicles, and it accumulated in β-amyloid plaques. Active immunization with ankG of arcAβ transgenic mice reduced brain β-amyloid pathology and increased brain levels of soluble Aβ(42). AnkG immunization induced a reduction in β-amyloid pathology, also in Swedish transgenic mice(.) Anti-ankG monoclonal antibodies reduced Aβ-induced loss of dendritic spines in hippocampal ArcAβ organotypic cultures. Together, these data established a role for ankG in the human adaptive immune response against resident brain proteins, and they show that ankG immunization reduces brain β-amyloid and its related neuropathology.

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Animals

KW - Ankyrins

KW - Antibodies

KW - Antibodies, Monoclonal

KW - Brain

KW - Cells, Cultured

KW - Hippocampus

KW - Humans

KW - Mice

KW - Mice, Transgenic

KW - Neurons

KW - Peptide Fragments

KW - Plaque, Amyloid

KW - Vaccination

U2 - 10.1038/mp.2012.70

DO - 10.1038/mp.2012.70

M3 - SCORING: Journal article

C2 - 22688190

VL - 18

SP - 358

EP - 368

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 3

ER -