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Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation

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Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation. / Nührich, Jana M; Geisler, Anne C; Steven, Daniel; Hoffmann, Boris A; Schäffer, Benjamin; Lund, Gunnar; Stehning, Christian; Radunski, Ulf K; Sultan, Arian; Schwarzl, Michael; Adam, Gerhard; Willems, Stephan; Muellerleile, Kai.

In: PACE, Vol. 40, No. 2, 02.2017, p. 175-182.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nührich, JM, Geisler, AC, Steven, D, Hoffmann, BA, Schäffer, B, Lund, G, Stehning, C, Radunski, UK, Sultan, A, Schwarzl, M, Adam, G, Willems, S & Muellerleile, K 2017, 'Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation', PACE, vol. 40, no. 2, pp. 175-182. https://doi.org/10.1111/pace.13004

APA

Nührich, J. M., Geisler, A. C., Steven, D., Hoffmann, B. A., Schäffer, B., Lund, G., Stehning, C., Radunski, U. K., Sultan, A., Schwarzl, M., Adam, G., Willems, S., & Muellerleile, K. (2017). Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation. PACE, 40(2), 175-182. https://doi.org/10.1111/pace.13004

Vancouver

Nührich JM, Geisler AC, Steven D, Hoffmann BA, Schäffer B, Lund G et al. Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation. PACE. 2017 Feb;40(2):175-182. https://doi.org/10.1111/pace.13004

Bibtex

@article{aa9cdbed46a449d6a3b36afc075080ab,
title = "Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation",
abstract = "BACKGROUND: Extensive and repeated substrate modification (SM) is frequently performed as an ablation strategy in persistent atrial fibrillation (persAF). The effect of these extended ablation strategies on atrial function has not been investigated sufficiently so far. The purpose was to assess atrial function by cardiac magnetic resonance (CMR) and its association with left atrial (LA) scar burden by electroanatomical voltage-mapping after multiple persAF ablation procedures.METHODS: We included 16 persAF patients who had ≥2 SM procedures and a control group (CG) of 21 persAF patients without prior ablation. CMR was performed in sinus rhythm at least 4 weeks after the last cardioversion. Active left and right (RA) atrial emptying fractions (AEF) as well as peak active left atrial appendage (LAA) emptying velocities were obtained by CMR flow measurements. Furthermore, LA scar burden was quantified on electroanatomical voltage maps by the portion of points with local voltage amplitude <0.2 mV.RESULTS: We found median LA-AEF to be lower (13 [9-22] vs 32 [26-36] %, P < 0.001) and median LA scar burden to be higher (40 [20-68] vs nine [3-18] %, P < 0.05) in the SM group compared with the CG. Furthermore, a significant correlation was found between mean LA voltage and LA-AEF (r2 = 0.62, P < 0.001). No significant differences were detected with respect to median RA-AEF (41 [28-48] vs 47 [35-50] %, P = 0.43) and median peak LAA emptying velocities (30 [16-40] vs 17 [13-28] cm/s, P = 0.07).CONCLUSIONS: Active LA function is preserved but significantly impaired and associated with ablation-related LA scar burden after multiple extensive persAF ablations.",
keywords = "Aged, Atrial Fibrillation, Atrial Function, Atrial Remodeling, Catheter Ablation, Chronic Disease, Cicatrix, Female, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Reoperation, Treatment Outcome, Clinical Trial, Journal Article",
author = "N{\"u}hrich, {Jana M} and Geisler, {Anne C} and Daniel Steven and Hoffmann, {Boris A} and Benjamin Sch{\"a}ffer and Gunnar Lund and Christian Stehning and Radunski, {Ulf K} and Arian Sultan and Michael Schwarzl and Gerhard Adam and Stephan Willems and Kai Muellerleile",
note = "{\textcopyright}2016 Wiley Periodicals, Inc.",
year = "2017",
month = feb,
doi = "10.1111/pace.13004",
language = "English",
volume = "40",
pages = "175--182",
journal = "PACE",
issn = "0147-8389",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Active Atrial Function and Atrial Scar Burden After Multiple Catheter Ablations of Persistent Atrial Fibrillation

AU - Nührich, Jana M

AU - Geisler, Anne C

AU - Steven, Daniel

AU - Hoffmann, Boris A

AU - Schäffer, Benjamin

AU - Lund, Gunnar

AU - Stehning, Christian

AU - Radunski, Ulf K

AU - Sultan, Arian

AU - Schwarzl, Michael

AU - Adam, Gerhard

AU - Willems, Stephan

AU - Muellerleile, Kai

N1 - ©2016 Wiley Periodicals, Inc.

PY - 2017/2

Y1 - 2017/2

N2 - BACKGROUND: Extensive and repeated substrate modification (SM) is frequently performed as an ablation strategy in persistent atrial fibrillation (persAF). The effect of these extended ablation strategies on atrial function has not been investigated sufficiently so far. The purpose was to assess atrial function by cardiac magnetic resonance (CMR) and its association with left atrial (LA) scar burden by electroanatomical voltage-mapping after multiple persAF ablation procedures.METHODS: We included 16 persAF patients who had ≥2 SM procedures and a control group (CG) of 21 persAF patients without prior ablation. CMR was performed in sinus rhythm at least 4 weeks after the last cardioversion. Active left and right (RA) atrial emptying fractions (AEF) as well as peak active left atrial appendage (LAA) emptying velocities were obtained by CMR flow measurements. Furthermore, LA scar burden was quantified on electroanatomical voltage maps by the portion of points with local voltage amplitude <0.2 mV.RESULTS: We found median LA-AEF to be lower (13 [9-22] vs 32 [26-36] %, P < 0.001) and median LA scar burden to be higher (40 [20-68] vs nine [3-18] %, P < 0.05) in the SM group compared with the CG. Furthermore, a significant correlation was found between mean LA voltage and LA-AEF (r2 = 0.62, P < 0.001). No significant differences were detected with respect to median RA-AEF (41 [28-48] vs 47 [35-50] %, P = 0.43) and median peak LAA emptying velocities (30 [16-40] vs 17 [13-28] cm/s, P = 0.07).CONCLUSIONS: Active LA function is preserved but significantly impaired and associated with ablation-related LA scar burden after multiple extensive persAF ablations.

AB - BACKGROUND: Extensive and repeated substrate modification (SM) is frequently performed as an ablation strategy in persistent atrial fibrillation (persAF). The effect of these extended ablation strategies on atrial function has not been investigated sufficiently so far. The purpose was to assess atrial function by cardiac magnetic resonance (CMR) and its association with left atrial (LA) scar burden by electroanatomical voltage-mapping after multiple persAF ablation procedures.METHODS: We included 16 persAF patients who had ≥2 SM procedures and a control group (CG) of 21 persAF patients without prior ablation. CMR was performed in sinus rhythm at least 4 weeks after the last cardioversion. Active left and right (RA) atrial emptying fractions (AEF) as well as peak active left atrial appendage (LAA) emptying velocities were obtained by CMR flow measurements. Furthermore, LA scar burden was quantified on electroanatomical voltage maps by the portion of points with local voltage amplitude <0.2 mV.RESULTS: We found median LA-AEF to be lower (13 [9-22] vs 32 [26-36] %, P < 0.001) and median LA scar burden to be higher (40 [20-68] vs nine [3-18] %, P < 0.05) in the SM group compared with the CG. Furthermore, a significant correlation was found between mean LA voltage and LA-AEF (r2 = 0.62, P < 0.001). No significant differences were detected with respect to median RA-AEF (41 [28-48] vs 47 [35-50] %, P = 0.43) and median peak LAA emptying velocities (30 [16-40] vs 17 [13-28] cm/s, P = 0.07).CONCLUSIONS: Active LA function is preserved but significantly impaired and associated with ablation-related LA scar burden after multiple extensive persAF ablations.

KW - Aged

KW - Atrial Fibrillation

KW - Atrial Function

KW - Atrial Remodeling

KW - Catheter Ablation

KW - Chronic Disease

KW - Cicatrix

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Middle Aged

KW - Reoperation

KW - Treatment Outcome

KW - Clinical Trial

KW - Journal Article

U2 - 10.1111/pace.13004

DO - 10.1111/pace.13004

M3 - SCORING: Journal article

C2 - 27995637

VL - 40

SP - 175

EP - 182

JO - PACE

JF - PACE

SN - 0147-8389

IS - 2

ER -