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Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19

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Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19. / Messlinger, Karl; Neuhuber, Winfried; May, Arne.

In: CEPHALALGIA, Vol. 42, No. 2, 02.2022, p. 176-180.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Messlinger, K, Neuhuber, W & May, A 2022, 'Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19', CEPHALALGIA, vol. 42, no. 2, pp. 176-180. https://doi.org/10.1177/03331024211036665

APA

Messlinger, K., Neuhuber, W., & May, A. (2022). Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19. CEPHALALGIA, 42(2), 176-180. https://doi.org/10.1177/03331024211036665

Vancouver

Messlinger K, Neuhuber W, May A. Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19. CEPHALALGIA. 2022 Feb;42(2):176-180. https://doi.org/10.1177/03331024211036665

Bibtex

@article{a646dd8ba38e41439c48b3771385a915,
title = "Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19",
abstract = "Clinical publications show consistently that headache is a common symptom in the coronavirus disease of 2019 (COVID-19). Several studies specifically investigated headache symptomatology and associated features in patients with COVID-19. The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.",
author = "Karl Messlinger and Winfried Neuhuber and Arne May",
year = "2022",
month = feb,
doi = "10.1177/03331024211036665",
language = "English",
volume = "42",
pages = "176--180",
journal = "CEPHALALGIA",
issn = "0333-1024",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19

AU - Messlinger, Karl

AU - Neuhuber, Winfried

AU - May, Arne

PY - 2022/2

Y1 - 2022/2

N2 - Clinical publications show consistently that headache is a common symptom in the coronavirus disease of 2019 (COVID-19). Several studies specifically investigated headache symptomatology and associated features in patients with COVID-19. The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.

AB - Clinical publications show consistently that headache is a common symptom in the coronavirus disease of 2019 (COVID-19). Several studies specifically investigated headache symptomatology and associated features in patients with COVID-19. The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.

U2 - 10.1177/03331024211036665

DO - 10.1177/03331024211036665

M3 - SCORING: Journal article

C2 - 34407648

VL - 42

SP - 176

EP - 180

JO - CEPHALALGIA

JF - CEPHALALGIA

SN - 0333-1024

IS - 2

ER -