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Activation of T cell calcium influx by the second messenger ADP-ribose.

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Activation of T cell calcium influx by the second messenger ADP-ribose. / Gasser, Andreas; Glassmeier, Günter; Fliegert, Ralf; Langhorst, Matthias F; Meinke, Stephan; Hein, Dörte; Krüger, Sylvia; Weber, Karin; Heiner, Inka; Oppenheimer, Norman; Schwarz, Jürgen R; Guse, Andreas H.

In: J BIOL CHEM, Vol. 281, No. 5, 5, 2006, p. 2489-2496.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gasser, A, Glassmeier, G, Fliegert, R, Langhorst, MF, Meinke, S, Hein, D, Krüger, S, Weber, K, Heiner, I, Oppenheimer, N, Schwarz, JR & Guse, AH 2006, 'Activation of T cell calcium influx by the second messenger ADP-ribose.', J BIOL CHEM, vol. 281, no. 5, 5, pp. 2489-2496. <http://www.ncbi.nlm.nih.gov/pubmed/16316998?dopt=Citation>

APA

Gasser, A., Glassmeier, G., Fliegert, R., Langhorst, M. F., Meinke, S., Hein, D., Krüger, S., Weber, K., Heiner, I., Oppenheimer, N., Schwarz, J. R., & Guse, A. H. (2006). Activation of T cell calcium influx by the second messenger ADP-ribose. J BIOL CHEM, 281(5), 2489-2496. [5]. http://www.ncbi.nlm.nih.gov/pubmed/16316998?dopt=Citation

Vancouver

Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D et al. Activation of T cell calcium influx by the second messenger ADP-ribose. J BIOL CHEM. 2006;281(5):2489-2496. 5.

Bibtex

@article{6f5d027c43004031b4431e5bee7249da,
title = "Activation of T cell calcium influx by the second messenger ADP-ribose.",
abstract = "Stimulation of Jurkat T cells by high concentrations of concanavalin A (ConA) induced an elevation of the endogenous adenosine diphosphoribose (ADPR) concentration and an inward current significantly different from the Ca2+ release-activated Ca2+ current (I(CRAC)). Electrophysiological characterization and activation of a similar current by infusion of ADPR indicated that the ConA-induced current is carried by TRPM2. Expression of TRPM2 in the plasma membrane of Jurkat T cells was demonstrated by reverse transcription-PCR, Western blot, and immunofluorescence. Inhibition of ADPR formation reduced ConA-mediated, but not store-operated, Ca2+ entry and prevented ConA-induced cell death of Jurkat cells. Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells.",
author = "Andreas Gasser and G{\"u}nter Glassmeier and Ralf Fliegert and Langhorst, {Matthias F} and Stephan Meinke and D{\"o}rte Hein and Sylvia Kr{\"u}ger and Karin Weber and Inka Heiner and Norman Oppenheimer and Schwarz, {J{\"u}rgen R} and Guse, {Andreas H}",
year = "2006",
language = "Deutsch",
volume = "281",
pages = "2489--2496",
journal = "J BIOL CHEM",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Activation of T cell calcium influx by the second messenger ADP-ribose.

AU - Gasser, Andreas

AU - Glassmeier, Günter

AU - Fliegert, Ralf

AU - Langhorst, Matthias F

AU - Meinke, Stephan

AU - Hein, Dörte

AU - Krüger, Sylvia

AU - Weber, Karin

AU - Heiner, Inka

AU - Oppenheimer, Norman

AU - Schwarz, Jürgen R

AU - Guse, Andreas H

PY - 2006

Y1 - 2006

N2 - Stimulation of Jurkat T cells by high concentrations of concanavalin A (ConA) induced an elevation of the endogenous adenosine diphosphoribose (ADPR) concentration and an inward current significantly different from the Ca2+ release-activated Ca2+ current (I(CRAC)). Electrophysiological characterization and activation of a similar current by infusion of ADPR indicated that the ConA-induced current is carried by TRPM2. Expression of TRPM2 in the plasma membrane of Jurkat T cells was demonstrated by reverse transcription-PCR, Western blot, and immunofluorescence. Inhibition of ADPR formation reduced ConA-mediated, but not store-operated, Ca2+ entry and prevented ConA-induced cell death of Jurkat cells. Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells.

AB - Stimulation of Jurkat T cells by high concentrations of concanavalin A (ConA) induced an elevation of the endogenous adenosine diphosphoribose (ADPR) concentration and an inward current significantly different from the Ca2+ release-activated Ca2+ current (I(CRAC)). Electrophysiological characterization and activation of a similar current by infusion of ADPR indicated that the ConA-induced current is carried by TRPM2. Expression of TRPM2 in the plasma membrane of Jurkat T cells was demonstrated by reverse transcription-PCR, Western blot, and immunofluorescence. Inhibition of ADPR formation reduced ConA-mediated, but not store-operated, Ca2+ entry and prevented ConA-induced cell death of Jurkat cells. Moreover, gene silencing of TRPM2 abolished the ADPR- and ConA-mediated inward current. Thus, ADPR is a novel second messenger significantly involved in ConA-mediated cell death in T cells.

M3 - SCORING: Zeitschriftenaufsatz

VL - 281

SP - 2489

EP - 2496

JO - J BIOL CHEM

JF - J BIOL CHEM

SN - 0021-9258

IS - 5

M1 - 5

ER -