Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.

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Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure. / Zolk, Oliver; Solbach, Thomas F; Eschenhagen, Thomas; Weidemann, Alexander; Fromm, Martin F.

In: BIOCHEM BIOPH RES CO, Vol. 376, No. 2, 2, 2008, p. 315-320.

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@article{2837a817a9e040fbbd6f348634178bff,
title = "Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.",
abstract = "The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts by quantitative RT-PCR and Western analysis. HIF-1alpha mRNA levels were significantly decreased while its natural antisense transcript aHIF was nearly twofold higher (p",
author = "Oliver Zolk and Solbach, {Thomas F} and Thomas Eschenhagen and Alexander Weidemann and Fromm, {Martin F}",
year = "2008",
language = "Deutsch",
volume = "376",
pages = "315--320",
journal = "BIOCHEM BIOPH RES CO",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.

AU - Zolk, Oliver

AU - Solbach, Thomas F

AU - Eschenhagen, Thomas

AU - Weidemann, Alexander

AU - Fromm, Martin F

PY - 2008

Y1 - 2008

N2 - The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts by quantitative RT-PCR and Western analysis. HIF-1alpha mRNA levels were significantly decreased while its natural antisense transcript aHIF was nearly twofold higher (p

AB - The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts by quantitative RT-PCR and Western analysis. HIF-1alpha mRNA levels were significantly decreased while its natural antisense transcript aHIF was nearly twofold higher (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 376

SP - 315

EP - 320

JO - BIOCHEM BIOPH RES CO

JF - BIOCHEM BIOPH RES CO

SN - 0006-291X

IS - 2

M1 - 2

ER -