Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.
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Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure. / Zolk, Oliver; Solbach, Thomas F; Eschenhagen, Thomas; Weidemann, Alexander; Fromm, Martin F.
In: BIOCHEM BIOPH RES CO, Vol. 376, No. 2, 2, 2008, p. 315-320.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.
AU - Zolk, Oliver
AU - Solbach, Thomas F
AU - Eschenhagen, Thomas
AU - Weidemann, Alexander
AU - Fromm, Martin F
PY - 2008
Y1 - 2008
N2 - The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts by quantitative RT-PCR and Western analysis. HIF-1alpha mRNA levels were significantly decreased while its natural antisense transcript aHIF was nearly twofold higher (p
AB - The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia in humans, but it is unknown whether this activation of HIF persists during chronic heart failure. The HIF system was characterized in left ventricular myocardia from 18 explanted failing hearts and 11 non-failing donor hearts by quantitative RT-PCR and Western analysis. HIF-1alpha mRNA levels were significantly decreased while its natural antisense transcript aHIF was nearly twofold higher (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 376
SP - 315
EP - 320
JO - BIOCHEM BIOPH RES CO
JF - BIOCHEM BIOPH RES CO
SN - 0006-291X
IS - 2
M1 - 2
ER -