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Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans

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Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans. / Weisser, Smilla; Müller, Madeleine; Rauh, Jonas; Eßer, Roland; Fuß, Johannes; Lutz, Beat; Haaker, Jan.

In: NEUROPSYCHOPHARMACOL, Vol. 47, No. 11, 10.2022, p. 1931-1938.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weisser, S, Müller, M, Rauh, J, Eßer, R, Fuß, J, Lutz, B & Haaker, J 2022, 'Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans', NEUROPSYCHOPHARMACOL, vol. 47, no. 11, pp. 1931-1938. https://doi.org/10.1038/s41386-022-01320-6

APA

Weisser, S., Müller, M., Rauh, J., Eßer, R., Fuß, J., Lutz, B., & Haaker, J. (2022). Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans. NEUROPSYCHOPHARMACOL, 47(11), 1931-1938. https://doi.org/10.1038/s41386-022-01320-6

Vancouver

Weisser S, Müller M, Rauh J, Eßer R, Fuß J, Lutz B et al. Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans. NEUROPSYCHOPHARMACOL. 2022 Oct;47(11):1931-1938. https://doi.org/10.1038/s41386-022-01320-6

Bibtex

@article{49332db2d2934a4087780bd9ee929ddd,
title = "Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans",
abstract = "Endocannabinoids (eCBs) are involved in buffering threat and stress responses. Elevation of circulating eCBs in humans was reported to strengthen inhibition (i.e., extinction) of threat responses and to reduce effects of stressors. However, it remains unclear whether the acquisition of threat responses involves a physiological change in circulating eCBs. Here, we demonstrate in male human volunteers that the plasma concentration of the eCB N-arachidonoylethanolamine (AEA) and its metabolite arachidonic acid (AA) are increased during acquisition of threat responses. Furthermore, elevated responses to a learned threat cue (e.g., rating of fear) were associated with individual increases in plasma concentration of the eCB 2-arachidonoylglycerol (2-AG). In complementing these observations, we found individual increases in AEA associated with elevated neural responses during threat learning in the amygdala. Our results thereby suggest that physiological increases in circulating eCB levels are part of a response mechanism to learned threats.",
keywords = "Amygdala, Arachidonic Acid/metabolism, Arachidonic Acids/metabolism, Endocannabinoids/metabolism, Fear/physiology, Humans, Male, Polyunsaturated Alkamides/metabolism",
author = "Smilla Weisser and Madeleine M{\"u}ller and Jonas Rauh and Roland E{\ss}er and Johannes Fu{\ss} and Beat Lutz and Jan Haaker",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = oct,
doi = "10.1038/s41386-022-01320-6",
language = "English",
volume = "47",
pages = "1931--1938",
journal = "NEUROPSYCHOPHARMACOL",
issn = "0893-133X",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans

AU - Weisser, Smilla

AU - Müller, Madeleine

AU - Rauh, Jonas

AU - Eßer, Roland

AU - Fuß, Johannes

AU - Lutz, Beat

AU - Haaker, Jan

N1 - © 2022. The Author(s).

PY - 2022/10

Y1 - 2022/10

N2 - Endocannabinoids (eCBs) are involved in buffering threat and stress responses. Elevation of circulating eCBs in humans was reported to strengthen inhibition (i.e., extinction) of threat responses and to reduce effects of stressors. However, it remains unclear whether the acquisition of threat responses involves a physiological change in circulating eCBs. Here, we demonstrate in male human volunteers that the plasma concentration of the eCB N-arachidonoylethanolamine (AEA) and its metabolite arachidonic acid (AA) are increased during acquisition of threat responses. Furthermore, elevated responses to a learned threat cue (e.g., rating of fear) were associated with individual increases in plasma concentration of the eCB 2-arachidonoylglycerol (2-AG). In complementing these observations, we found individual increases in AEA associated with elevated neural responses during threat learning in the amygdala. Our results thereby suggest that physiological increases in circulating eCB levels are part of a response mechanism to learned threats.

AB - Endocannabinoids (eCBs) are involved in buffering threat and stress responses. Elevation of circulating eCBs in humans was reported to strengthen inhibition (i.e., extinction) of threat responses and to reduce effects of stressors. However, it remains unclear whether the acquisition of threat responses involves a physiological change in circulating eCBs. Here, we demonstrate in male human volunteers that the plasma concentration of the eCB N-arachidonoylethanolamine (AEA) and its metabolite arachidonic acid (AA) are increased during acquisition of threat responses. Furthermore, elevated responses to a learned threat cue (e.g., rating of fear) were associated with individual increases in plasma concentration of the eCB 2-arachidonoylglycerol (2-AG). In complementing these observations, we found individual increases in AEA associated with elevated neural responses during threat learning in the amygdala. Our results thereby suggest that physiological increases in circulating eCB levels are part of a response mechanism to learned threats.

KW - Amygdala

KW - Arachidonic Acid/metabolism

KW - Arachidonic Acids/metabolism

KW - Endocannabinoids/metabolism

KW - Fear/physiology

KW - Humans

KW - Male

KW - Polyunsaturated Alkamides/metabolism

U2 - 10.1038/s41386-022-01320-6

DO - 10.1038/s41386-022-01320-6

M3 - SCORING: Journal article

C2 - 35562542

VL - 47

SP - 1931

EP - 1938

JO - NEUROPSYCHOPHARMACOL

JF - NEUROPSYCHOPHARMACOL

SN - 0893-133X

IS - 11

ER -