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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. / Schüller, Ulrich; Heine, Vivi M; Mao, Junhao; Kho, Alvin T; Dillon, Allison K; Han, Young-Goo; Huillard, Emmanuelle; Sun, Tao; Ligon, Azra H; Qian, Ying; Ma, Qiufu; Alvarez-Buylla, Arturo; McMahon, Andrew P; Rowitch, David H; Ligon, Keith L.

In: CANCER CELL, Vol. 14, No. 2, 12.08.2008, p. 123-34.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schüller, U, Heine, VM, Mao, J, Kho, AT, Dillon, AK, Han, Y-G, Huillard, E, Sun, T, Ligon, AH, Qian, Y, Ma, Q, Alvarez-Buylla, A, McMahon, AP, Rowitch, DH & Ligon, KL 2008, 'Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma', CANCER CELL, vol. 14, no. 2, pp. 123-34. https://doi.org/10.1016/j.ccr.2008.07.005

APA

Schüller, U., Heine, V. M., Mao, J., Kho, A. T., Dillon, A. K., Han, Y-G., Huillard, E., Sun, T., Ligon, A. H., Qian, Y., Ma, Q., Alvarez-Buylla, A., McMahon, A. P., Rowitch, D. H., & Ligon, K. L. (2008). Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. CANCER CELL, 14(2), 123-34. https://doi.org/10.1016/j.ccr.2008.07.005

Vancouver

Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han Y-G et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. CANCER CELL. 2008 Aug 12;14(2):123-34. https://doi.org/10.1016/j.ccr.2008.07.005

Bibtex

@article{8ad8b173f06c40a681593c626a06c679,
title = "Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma",
abstract = "Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted central nervous system (CNS) progenitors. We observed that normal unipotent cerebellar granule neuron precursors (CGNPs) derive from hGFAP(+) and Olig2(+) rhombic lip progenitors. Hh activation in a spectrum of early- and late-stage CNS progenitors generated similar medulloblastomas, but not other brain cancers, indicating that acquisition of CGNP identity is essential for tumorigenesis. We show in human and mouse medulloblastoma that cells expressing the glia-associated markers Gfap and Olig2 are neoplastic and retain features of embryonic-type granule lineage progenitors. Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors.",
keywords = "Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Lineage, Cerebrum, Crosses, Genetic, Female, Glial Fibrillary Acidic Protein, Hedgehog Proteins, Humans, Male, Medulloblastoma, Mice, Nerve Tissue Proteins, Neurons, Phenotype, Receptors, G-Protein-Coupled, Smoothened Receptor, Stem Cells, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Ulrich Sch{\"u}ller and Heine, {Vivi M} and Junhao Mao and Kho, {Alvin T} and Dillon, {Allison K} and Young-Goo Han and Emmanuelle Huillard and Tao Sun and Ligon, {Azra H} and Ying Qian and Qiufu Ma and Arturo Alvarez-Buylla and McMahon, {Andrew P} and Rowitch, {David H} and Ligon, {Keith L}",
year = "2008",
month = aug,
day = "12",
doi = "10.1016/j.ccr.2008.07.005",
language = "English",
volume = "14",
pages = "123--34",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

AU - Schüller, Ulrich

AU - Heine, Vivi M

AU - Mao, Junhao

AU - Kho, Alvin T

AU - Dillon, Allison K

AU - Han, Young-Goo

AU - Huillard, Emmanuelle

AU - Sun, Tao

AU - Ligon, Azra H

AU - Qian, Ying

AU - Ma, Qiufu

AU - Alvarez-Buylla, Arturo

AU - McMahon, Andrew P

AU - Rowitch, David H

AU - Ligon, Keith L

PY - 2008/8/12

Y1 - 2008/8/12

N2 - Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted central nervous system (CNS) progenitors. We observed that normal unipotent cerebellar granule neuron precursors (CGNPs) derive from hGFAP(+) and Olig2(+) rhombic lip progenitors. Hh activation in a spectrum of early- and late-stage CNS progenitors generated similar medulloblastomas, but not other brain cancers, indicating that acquisition of CGNP identity is essential for tumorigenesis. We show in human and mouse medulloblastoma that cells expressing the glia-associated markers Gfap and Olig2 are neoplastic and retain features of embryonic-type granule lineage progenitors. Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors.

AB - Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted central nervous system (CNS) progenitors. We observed that normal unipotent cerebellar granule neuron precursors (CGNPs) derive from hGFAP(+) and Olig2(+) rhombic lip progenitors. Hh activation in a spectrum of early- and late-stage CNS progenitors generated similar medulloblastomas, but not other brain cancers, indicating that acquisition of CGNP identity is essential for tumorigenesis. We show in human and mouse medulloblastoma that cells expressing the glia-associated markers Gfap and Olig2 are neoplastic and retain features of embryonic-type granule lineage progenitors. Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors.

KW - Animals

KW - Basic Helix-Loop-Helix Transcription Factors

KW - Cell Lineage

KW - Cerebrum

KW - Crosses, Genetic

KW - Female

KW - Glial Fibrillary Acidic Protein

KW - Hedgehog Proteins

KW - Humans

KW - Male

KW - Medulloblastoma

KW - Mice

KW - Nerve Tissue Proteins

KW - Neurons

KW - Phenotype

KW - Receptors, G-Protein-Coupled

KW - Smoothened Receptor

KW - Stem Cells

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ccr.2008.07.005

DO - 10.1016/j.ccr.2008.07.005

M3 - SCORING: Journal article

C2 - 18691547

VL - 14

SP - 123

EP - 134

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 2

ER -